Visualization of pathology across the cohort. Spatial renderings in mutation non-carriers, asymptomatic mutation carriers, and symptomatic mutation carriers for amyloid-β deposition measured with PiB PET, glucose metabolism measured with FDG PET, neurofibrillary tau pathology measured with AV1451, and cortical thickness measured with MRI. PET values represent SUVRs relative to the cerebellar cortex and cortical thickness values are in millimetres. For convenience, data are shown for the inflated left hemisphere.