Prediction-corrected visual predictive check from the final model. The black dots are the observations. The blue solid lines are the 10^th and 90^th percentiles of prediction-corrected daptomycin concentrations and the magenta solid line is the median of observations (i.e. 50th percentile). The blue areas are the 90% CIs of the 10th and 90th simulated percentiles and the pink area is the 90% CI of the simulated median. Simulated percentiles were obtained from 1000 replicates of each individual dataset and the final model parameter estimates. Observations greater than 100 mg/L (n = 9) are not shown for ease of graphical display. Of note, the x-axis represents the time after the previous dose, i.e. the dose administered the day before TDM was performed. This figure appears in colour in the online version of JAC and in black and white in the print version of JAC.