Absolute and normalized lesion volumes in cervical cord regions of interest. Absolute lesion volumes (mm³) and normalized lesion volumes per phenotype for (A) grey matter (GM) versus white matter (WM), and (B) dorsal column (DC) versus lateral funiculi (LF) versus ventral funiculi (VF). Normalized lesion volumes for whole cohort in (C) cervical spine levels C1–C7. For analyses involving grey matter, data were limited to T₂-weighted MRI images (n = 236). Normalized lesion volumes represent the proportion of a region affected by lesions. Box and whisker plots represent median, interquartile range and range.