Figure 4.
PCB 95 increases dendritic arborization of female cortical neurons via effect on primary and nonprimary dendrites. Male (A–D) and female (E–H) mouse cortical neuron-glia co-cultures were exposed for 48 h to vehicle (0.1% DMSO) or varying concentrations of PCB 95. Fold-change relative to sex-matched vehicle control was quantified for: (A, E) the total number of primary dendrites; (B, F) mean length of the primary dendrites (μm); (C, G) the number of nonprimary dendrites; and (D, H) the mean length of nonprimary dendrites (μm). Data are presented as mean ± SE (n = 13–70 neurons from at least 3 independent dissections). *Significantly different from vehicle control at p < .05, as determined using Kruskal-Wallis test followed by Dunn’s multiple comparison post hoc test.

PCB 95 increases dendritic arborization of female cortical neurons via effect on primary and nonprimary dendrites. Male (A–D) and female (E–H) mouse cortical neuron-glia co-cultures were exposed for 48 h to vehicle (0.1% DMSO) or varying concentrations of PCB 95. Fold-change relative to sex-matched vehicle control was quantified for: (A, E) the total number of primary dendrites; (B, F) mean length of the primary dendrites (μm); (C, G) the number of nonprimary dendrites; and (D, H) the mean length of nonprimary dendrites (μm). Data are presented as mean ± SE (n = 13–70 neurons from at least 3 independent dissections). *Significantly different from vehicle control at p < .05, as determined using Kruskal-Wallis test followed by Dunn’s multiple comparison post hoc test.

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