Figure 4.
PCB 95 increases dendritic arborization of female cortical neurons via effect on primary and nonprimary dendrites. Male (A–D) and female (E–H) mouse cortical neuron-glia co-cultures were exposed for 48 h to vehicle (0.1% DMSO) or varying concentrations of PCB 95. Fold-change relative to sex-matched vehicle control was quantified for: (A, E) the total number of primary dendrites; (B, F) mean length of the primary dendrites (μm); (C, G) the number of nonprimary dendrites; and (D, H) the mean length of nonprimary dendrites (μm). Data are presented as mean ± SE (n = 13–70 neurons from at least 3 independent dissections). *Significantly different from vehicle control at p < .05, as determined using Kruskal-Wallis test followed by Dunn’s multiple comparison post hoc test.