Differences in the expression of genes in GD mice. (a) Differences in the expression of genes centrally involved in certain biochemical pathways are observed when comparing groups of GD mice raised with a Se-deficient vs an RDA chow. (a) The 10 most substantially upregulated processes according to GO classification. (b) Presentation of the 10 most substantially upregulated biological pathways. The processes controlling the development of immune and red blood cells and the enzymes involved in porphyrin metabolism and homeostatic processes were affected by the Se-deficient vs RDA diet. (c) Presentation of the core gene networks affected, as identified by protein–protein interaction network analysis.