Covariation of brain activation and age. Statistical parametric maps of significant differences in covariation of brain activation with age (with respect to group) during the self task (see Methods section for details). SPMs are thresholded at P < 0.005 (voxel level, uncorrected) and overlayed on a mean anatomical T1 image of all participants. Depicted clusters (red arrows) were significant at the whole brain level ( P < 0.05, cluster-level corrected for multiple comparisons), except for the peak in the MPFC ( P < 0.05, voxel level corrected for multiple comparisons (ROI), white arrow). Correlation plots depict individual contrast estimates for the self task as a function of age in the activation peak. Correlation coefficients (R) and linear best fit estimates are given separately for each group (blue = TDC; red = individuals with ASD).