Ingenuity pathway analysis of ‘Top diseases and biofunctions’. The analysis of the ‘top diseases and biofunctions’ was performed using only the miRNAs differentially expressed in dNK versus pbNK cells in exploratory analysis (qRT-PCR based array) and in the subsequent validation step (qRT-PCR single miRNA Assay). Only nine miRNAs were selected for this analysis, namely miR-10b, miR-214, miR-200a-3p, miR-130b-3p, miR-125a-5p, miR-212-3p, miR-454, miR-210-3p and miR-132. This analysis (confidence = Experimentally Observed) shows several categories that can be grouped in three main groups, such as ‘diseases and disorders’, ‘cellular and molecular functions’ and ‘physiological system development and function’. The number of miRNAs belonging to each category is indicated on the right of the panel. Categories ‘organismal injury and abnormalities’, ‘reproductive system disease’, ‘cellular development’, ‘cellular growth and proliferation’ and ‘cellular movement’ are the ones with the higher number of miRNAs target. As explained in the main text, Ingenuity pathway analysis (IPA) identifies miR-212-3p and miR-132 as the same, due to their identical core seed sequence; therefore, the maximum number of molecules present in the analysis is equivalent to eight. The range of P values of each category is indicated within the panel. Statistical analysis was performed using Student’s t-test. Error bars represent SD.