Astrocytic connexin gene expression is strongly repressed in both cortical and subcortical regions in cases compared to controls. CX30 (a-e) is significantly downregulated in the (a) motor cortex (U₍₃₈₎=40, P=.024), (b) visual cortex (U₍₃₈₎=40, P<.0001), (d) mdThAl (U₍₃₉₎=57, P<.0001), and (e) caudate nucleus (U₍₃₉₎=103, P=.015), and CX43 (f-j) showed decreases in the (f) motor cortex (U₍₄₀₎=67, P=.0002), (g) visual cortex (U₍₄₀₎=81.5, P=.001), (h) cerebellum (U₍₄₂₎=84, P=.0004), and (j) caudate nucleus (U₍₄₀₎=83, P=.0012). Cases showed a significant increase of CX30 in (c) cerebellum (t₍₄₁₎= 2.78, P=.008).