Subcutaneous administration with VEN-120 attenuates chronic murine ileitis. A] VEN-120 treatment of TNF^ΔARE/+ mice resulted in a significant decrease in FD4 transport across the intestinal epithelial barrier. B] Two-week treatment of TNF^ΔARE/+ mice with VEN-120 results in a significant improvement in tissue architecture and a significant decrease in histological indices of inflammation. C] Representative H&E staining demonstrates improved architectural appearance and decreased chronic and acute inflammation. D] Flow cytometric analysis demonstrating a significant reduction in the influx of naïve CD4⁺ cells known to perpetuate inflammation in this model at the ileal LP, MLN and at the spleen. [*p < 0.05; **p < 0.01, one-way ANOVA, n = 6]. MLN, mesenteric lymph nodes; LP, lamina propria; ANOVA, analysis of variance; H&E, haematoxylin and eosin.