Visual predictive check of the final miltefosine population pharmacokinetic model in Eastern African patients with VL receiving 10 days of miltefosine (2.5 mg/kg/day) in combination therapy (left plot) or 28 days of miltefosine (2.5 mg/kg/day) monotherapy (right plot). Insets in the top right corner show a magnification of the same plot during the initial treatment period (0–28 days). Circles represent the observed concentrations, the solid line the 50th percentile of the observed data and the dashed lines the 10th and 90th percentiles of the observed data. Shaded areas indicate the simulated 95% CI of the 10th and 90th (light grey) and 50th (dark grey) percentiles of the simulations (n = 1000 simulations).