Proportion and level of homotypic neutralizing antibodies to each serotype in dengue virus (DENV)–naive subjects who received the chimeric yellow fever–dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV). The antibody depletion assay was used to measure proportions of DENV type-specific (homotypic) neutralizing antibodies induced by CYD-TDV in DENV-naive subjects. A, Each data point represents the percentage of the total neutralizing antibody response to the specified serotype attributed to type-specific antibodies; horizontal bars represent geometric mean titers. Two-way analysis of variance (ANOVA) was used to calculate P values (DENV4 vs DENV1, P = .003; DENV4 vs DENV2, P < .001; DENV4 vs DENV3, P = .005). B, Each data point represents the absolute level of homotypic neutralizing antibody to the specified serotype (50% neutralization antibody titer [Neut50]); horizontal bars represent geometric mean titers. Two-way ANOVA was used to calculate P values (DENV4 vs DENV1, P = .001; DENV4 vs DENV2, P = .006; DENV4 vs DENV3, P = .004).