Figure 4.
VapC proteins target stem-loop structures in rRNA or tRNA. (A) VapC-mt20 (VapC20) targets the conserved sarcin–ricin loop (SRL) of 23 rRNA. VapC-mt4 cleaves three tRNAs from M. tuberculosis: tRNAAla2 (B), tRNASer26 and (C) tRNASer24. Yellow arrows indicate the position of cleavage by VapC-mt4. tRNA anticodons are shaded in gray and the VapC-mt4 consensus is indicated in red. Note that in tRNASer26 (C) and tRNASer24 (D) the actual base numbers for the anticodon are 35–37.

VapC proteins target stem-loop structures in rRNA or tRNA. (A) VapC-mt20 (VapC20) targets the conserved sarcin–ricin loop (SRL) of 23 rRNA. VapC-mt4 cleaves three tRNAs from M. tuberculosis: tRNAAla2 (B), tRNASer26 and (C) tRNASer24. Yellow arrows indicate the position of cleavage by VapC-mt4. tRNA anticodons are shaded in gray and the VapC-mt4 consensus is indicated in red. Note that in tRNASer26 (C) and tRNASer24 (D) the actual base numbers for the anticodon are 35–37.

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