DNA methylation in human adipocytes. (A) Methylation in CpG loci (β value) in proximity to (defined as <1.5 kb upstream to transcription start site, in gene bodies, in 5′- or 3′-untranslated region) protein-encoding genes were compared between nonobese and obese individuals in subcohort 1. Based on data from subcohort 1, GO analyses were performed for genes associated with (B) higher or (C) lower expression in relation to hypermethylation in neighboring CpGs. **P < 0.01.