TOE before (1a, two-dimensional; 1b, colour-Doppler; 1c, three-dimensional) and 6 days after (2a, two-dimensional; 2b, colour-Doppler; 2c, three-dimensional) PFO closure with the Cribriform Amplatzer device. The white arrows show the PFO. LA: left atrium; PFO: patent foramen ovale; RA: right atrium; TOE: transoesophageal echocardiography.