Temporal Trends in Isolation of Salmonella and Estimated Minimum Incidence of Salmonella Bloodstream Infection at Queen Elizabeth Central Hospital, Blantyre, Malawi, 1998–2014
Characteristic . | 1998 . | 1999 . | 2000 . | 2001 . | 2002 . | 2003 . | 2004 . | 2005 . | 2006 . | 2007 . | 2008 . | 2009 . | 2010 . | 2011 . | 2012 . | 2013 . | 2014 . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Typhoidal Salmonella isolated, No.a | 24 | 13 | 5 | 4 | 4 | 9 | 17 | 19 | 18 | 10 | 16 | 19 | 18 | 67 | 186 | 843 | 782 |
Incidence, 100/100 000/yb | 9.1 | 4.9 | 1.9 | 1.4 | 1.4 | 3.1 | 5.7 | 6.2 | 5.7 | 3.1 | 4.8 | 5.5 | 5 | 23.4 | 47.5 | 206.6 | 184.1 |
Case fatality rate, %c | 3 [20] | 3 [20] | 3 [20] | ||||||||||||||
Total nontyphoidal Salmonella, No. | 541 | 623 | 686 | 783 | 1381 | 1323 | 876 | 847 | 671 | 629 | 498 | 343 | 264 | 216 | 154 | 148 | 138 |
Salmonella Typhimurium, No. | 441 | 375 | 397 | 446 | 1040 | 1187 | 710 | 737 | 601 | 563 | 443 | 287 | 209 | 185 | 131 | 129 | 119 |
Salmonella Enteritidis, No. | 79 | 209 | 232 | 318 | 226 | 106 | 79 | 78 | 53 | 49 | 42 | 36 | 34 | 22 | 19 | 12 | 13 |
Other Salmonella serovars, No. | 21 | 39 | 57 | 19 | 115 | 30 | 87 | 32 | 17 | 17 | 13 | 20 | 21 | 9 | 4 | 7 | 6 |
Incidence, 100/100 000/yearb | 103 | 117 | 130 | 137 | 242 | 228 | 147 | 138 | 106 | 97 | 75 | 50 | 37 | 30 | 20 | 19 | 16 |
Case fatality rate, %c | |||||||||||||||||
Adults | 29 [18] | 47 [2] | 27 [18] | 19 [18] | 20 [18] | 11 [19] | 11 [19] | ||||||||||
Children | 23 [3] | 20d | |||||||||||||||
Malaria prevalence in febrile children, % | 35 | 33 | 24 | 26 | 17 | 20 | 25 | 26 | 25 | 22 | |||||||
Total No. of blood cultures taken | 8545 | 7823 | 8052 | 7653 | 8978 | 11 174 | 10 653 | 12 933 | 10 123 | 9167 | 8628 | 7991 | 8507 | 9890 | 10 433 | 12 815 | 13 663 |
Estimated population, Blantyre urban, thousands | 527 | 530 | 526 | 571 | 571 | 580 | 596 | 613 | 632 | 645 | 663 | 692 | 721 | 752 | 783 | 816 | 850 |
Characteristic . | 1998 . | 1999 . | 2000 . | 2001 . | 2002 . | 2003 . | 2004 . | 2005 . | 2006 . | 2007 . | 2008 . | 2009 . | 2010 . | 2011 . | 2012 . | 2013 . | 2014 . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Typhoidal Salmonella isolated, No.a | 24 | 13 | 5 | 4 | 4 | 9 | 17 | 19 | 18 | 10 | 16 | 19 | 18 | 67 | 186 | 843 | 782 |
Incidence, 100/100 000/yb | 9.1 | 4.9 | 1.9 | 1.4 | 1.4 | 3.1 | 5.7 | 6.2 | 5.7 | 3.1 | 4.8 | 5.5 | 5 | 23.4 | 47.5 | 206.6 | 184.1 |
Case fatality rate, %c | 3 [20] | 3 [20] | 3 [20] | ||||||||||||||
Total nontyphoidal Salmonella, No. | 541 | 623 | 686 | 783 | 1381 | 1323 | 876 | 847 | 671 | 629 | 498 | 343 | 264 | 216 | 154 | 148 | 138 |
Salmonella Typhimurium, No. | 441 | 375 | 397 | 446 | 1040 | 1187 | 710 | 737 | 601 | 563 | 443 | 287 | 209 | 185 | 131 | 129 | 119 |
Salmonella Enteritidis, No. | 79 | 209 | 232 | 318 | 226 | 106 | 79 | 78 | 53 | 49 | 42 | 36 | 34 | 22 | 19 | 12 | 13 |
Other Salmonella serovars, No. | 21 | 39 | 57 | 19 | 115 | 30 | 87 | 32 | 17 | 17 | 13 | 20 | 21 | 9 | 4 | 7 | 6 |
Incidence, 100/100 000/yearb | 103 | 117 | 130 | 137 | 242 | 228 | 147 | 138 | 106 | 97 | 75 | 50 | 37 | 30 | 20 | 19 | 16 |
Case fatality rate, %c | |||||||||||||||||
Adults | 29 [18] | 47 [2] | 27 [18] | 19 [18] | 20 [18] | 11 [19] | 11 [19] | ||||||||||
Children | 23 [3] | 20d | |||||||||||||||
Malaria prevalence in febrile children, % | 35 | 33 | 24 | 26 | 17 | 20 | 25 | 26 | 25 | 22 | |||||||
Total No. of blood cultures taken | 8545 | 7823 | 8052 | 7653 | 8978 | 11 174 | 10 653 | 12 933 | 10 123 | 9167 | 8628 | 7991 | 8507 | 9890 | 10 433 | 12 815 | 13 663 |
Estimated population, Blantyre urban, thousands | 527 | 530 | 526 | 571 | 571 | 580 | 596 | 613 | 632 | 645 | 663 | 692 | 721 | 752 | 783 | 816 | 850 |
a All Salmonella Typhi, no Salmonella Paratyphi detected.
b Assumes sensitivity of blood culture 50%.
c Case fatality rate where available from substudies.
d Previously unpublished data.
Temporal Trends in Isolation of Salmonella and Estimated Minimum Incidence of Salmonella Bloodstream Infection at Queen Elizabeth Central Hospital, Blantyre, Malawi, 1998–2014
Characteristic . | 1998 . | 1999 . | 2000 . | 2001 . | 2002 . | 2003 . | 2004 . | 2005 . | 2006 . | 2007 . | 2008 . | 2009 . | 2010 . | 2011 . | 2012 . | 2013 . | 2014 . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Typhoidal Salmonella isolated, No.a | 24 | 13 | 5 | 4 | 4 | 9 | 17 | 19 | 18 | 10 | 16 | 19 | 18 | 67 | 186 | 843 | 782 |
Incidence, 100/100 000/yb | 9.1 | 4.9 | 1.9 | 1.4 | 1.4 | 3.1 | 5.7 | 6.2 | 5.7 | 3.1 | 4.8 | 5.5 | 5 | 23.4 | 47.5 | 206.6 | 184.1 |
Case fatality rate, %c | 3 [20] | 3 [20] | 3 [20] | ||||||||||||||
Total nontyphoidal Salmonella, No. | 541 | 623 | 686 | 783 | 1381 | 1323 | 876 | 847 | 671 | 629 | 498 | 343 | 264 | 216 | 154 | 148 | 138 |
Salmonella Typhimurium, No. | 441 | 375 | 397 | 446 | 1040 | 1187 | 710 | 737 | 601 | 563 | 443 | 287 | 209 | 185 | 131 | 129 | 119 |
Salmonella Enteritidis, No. | 79 | 209 | 232 | 318 | 226 | 106 | 79 | 78 | 53 | 49 | 42 | 36 | 34 | 22 | 19 | 12 | 13 |
Other Salmonella serovars, No. | 21 | 39 | 57 | 19 | 115 | 30 | 87 | 32 | 17 | 17 | 13 | 20 | 21 | 9 | 4 | 7 | 6 |
Incidence, 100/100 000/yearb | 103 | 117 | 130 | 137 | 242 | 228 | 147 | 138 | 106 | 97 | 75 | 50 | 37 | 30 | 20 | 19 | 16 |
Case fatality rate, %c | |||||||||||||||||
Adults | 29 [18] | 47 [2] | 27 [18] | 19 [18] | 20 [18] | 11 [19] | 11 [19] | ||||||||||
Children | 23 [3] | 20d | |||||||||||||||
Malaria prevalence in febrile children, % | 35 | 33 | 24 | 26 | 17 | 20 | 25 | 26 | 25 | 22 | |||||||
Total No. of blood cultures taken | 8545 | 7823 | 8052 | 7653 | 8978 | 11 174 | 10 653 | 12 933 | 10 123 | 9167 | 8628 | 7991 | 8507 | 9890 | 10 433 | 12 815 | 13 663 |
Estimated population, Blantyre urban, thousands | 527 | 530 | 526 | 571 | 571 | 580 | 596 | 613 | 632 | 645 | 663 | 692 | 721 | 752 | 783 | 816 | 850 |
Characteristic . | 1998 . | 1999 . | 2000 . | 2001 . | 2002 . | 2003 . | 2004 . | 2005 . | 2006 . | 2007 . | 2008 . | 2009 . | 2010 . | 2011 . | 2012 . | 2013 . | 2014 . |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Typhoidal Salmonella isolated, No.a | 24 | 13 | 5 | 4 | 4 | 9 | 17 | 19 | 18 | 10 | 16 | 19 | 18 | 67 | 186 | 843 | 782 |
Incidence, 100/100 000/yb | 9.1 | 4.9 | 1.9 | 1.4 | 1.4 | 3.1 | 5.7 | 6.2 | 5.7 | 3.1 | 4.8 | 5.5 | 5 | 23.4 | 47.5 | 206.6 | 184.1 |
Case fatality rate, %c | 3 [20] | 3 [20] | 3 [20] | ||||||||||||||
Total nontyphoidal Salmonella, No. | 541 | 623 | 686 | 783 | 1381 | 1323 | 876 | 847 | 671 | 629 | 498 | 343 | 264 | 216 | 154 | 148 | 138 |
Salmonella Typhimurium, No. | 441 | 375 | 397 | 446 | 1040 | 1187 | 710 | 737 | 601 | 563 | 443 | 287 | 209 | 185 | 131 | 129 | 119 |
Salmonella Enteritidis, No. | 79 | 209 | 232 | 318 | 226 | 106 | 79 | 78 | 53 | 49 | 42 | 36 | 34 | 22 | 19 | 12 | 13 |
Other Salmonella serovars, No. | 21 | 39 | 57 | 19 | 115 | 30 | 87 | 32 | 17 | 17 | 13 | 20 | 21 | 9 | 4 | 7 | 6 |
Incidence, 100/100 000/yearb | 103 | 117 | 130 | 137 | 242 | 228 | 147 | 138 | 106 | 97 | 75 | 50 | 37 | 30 | 20 | 19 | 16 |
Case fatality rate, %c | |||||||||||||||||
Adults | 29 [18] | 47 [2] | 27 [18] | 19 [18] | 20 [18] | 11 [19] | 11 [19] | ||||||||||
Children | 23 [3] | 20d | |||||||||||||||
Malaria prevalence in febrile children, % | 35 | 33 | 24 | 26 | 17 | 20 | 25 | 26 | 25 | 22 | |||||||
Total No. of blood cultures taken | 8545 | 7823 | 8052 | 7653 | 8978 | 11 174 | 10 653 | 12 933 | 10 123 | 9167 | 8628 | 7991 | 8507 | 9890 | 10 433 | 12 815 | 13 663 |
Estimated population, Blantyre urban, thousands | 527 | 530 | 526 | 571 | 571 | 580 | 596 | 613 | 632 | 645 | 663 | 692 | 721 | 752 | 783 | 816 | 850 |
a All Salmonella Typhi, no Salmonella Paratyphi detected.
b Assumes sensitivity of blood culture 50%.
c Case fatality rate where available from substudies.
d Previously unpublished data.
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