TABLE 1. Open in new tab Overlapping...

Symptoms	Signs	Overlapping conditions
Features that best discriminate Cushing's syndrome; most do not have a high sensitivity
	Easy bruising
	Facial plethora
	Proximal myopathy (or proximal muscle weakness)
	Striae (especially if reddish purple and > 1 cm wide)
	In children, weight gain with decreasing growth velocity
Cushing's syndrome features in the general population that are common and/or less discriminatory
Depression	Dorsocervical fat pad (“buffalo hump”)	Hypertension^b
Fatigue	Facial fullness	Incidental adrenal mass
Weight gain	Obesity	Vertebral osteoporosis^b
Back pain	Supraclavicular fullness	Polycystic ovary syndrome
Changes in appetite	Thin skin^b	Type 2 diabetes^b
Decreased concentration	Peripheral edema	Hypokalemia
Decreased libido	Acne	Kidney stones
Impaired memory (especially short term)	Hirsutism or female balding	Unusual infections
Insomnia	Poor skin healing
Irritability
Menstrual abnormalities
In children, slow growth	In children, abnormal genital virilization
	In children, short stature
	In children, pseudoprecocious puberty or delayed puberty

Symptoms

Signs

Overlapping conditions

Features that best discriminate Cushing's syndrome; most do not have a high sensitivity

Easy bruising

Facial plethora

Proximal myopathy (or proximal muscle weakness)

Striae (especially if reddish purple and > 1 cm wide)

In children, weight gain with decreasing growth velocity

Cushing's syndrome features in the general population that are common and/or less discriminatory

Depression

Dorsocervical fat pad (“buffalo hump”)

Hypertension^b

Fatigue

Facial fullness

Incidental adrenal mass

Weight gain

Obesity

Vertebral osteoporosis^b

Back pain

Supraclavicular fullness

Polycystic ovary syndrome

Changes in appetite

Thin skin^b

Type 2 diabetes^b

Decreased concentration

Peripheral edema

Hypokalemia

Decreased libido

Acne

Kidney stones

Impaired memory (especially short term)

Hirsutism or female balding

Unusual infections

Insomnia

Poor skin healing

Irritability

Menstrual abnormalities

In children, slow growth

In children, abnormal genital virilization

In children, short stature

In children, pseudoprecocious puberty or delayed puberty

Symptoms	Signs	Overlapping conditions
Features that best discriminate Cushing's syndrome; most do not have a high sensitivity
	Easy bruising
	Facial plethora
	Proximal myopathy (or proximal muscle weakness)
	Striae (especially if reddish purple and > 1 cm wide)
	In children, weight gain with decreasing growth velocity
Cushing's syndrome features in the general population that are common and/or less discriminatory
Depression	Dorsocervical fat pad (“buffalo hump”)	Hypertension^b
Fatigue	Facial fullness	Incidental adrenal mass
Weight gain	Obesity	Vertebral osteoporosis^b
Back pain	Supraclavicular fullness	Polycystic ovary syndrome
Changes in appetite	Thin skin^b	Type 2 diabetes^b
Decreased concentration	Peripheral edema	Hypokalemia
Decreased libido	Acne	Kidney stones
Impaired memory (especially short term)	Hirsutism or female balding	Unusual infections
Insomnia	Poor skin healing
Irritability
Menstrual abnormalities
In children, slow growth	In children, abnormal genital virilization
	In children, short stature
	In children, pseudoprecocious puberty or delayed puberty

TABLE 1.

Open in new tab

Overlapping conditions and clinical features of Cushing's syndrome^a

Symptoms	Signs	Overlapping conditions
Features that best discriminate Cushing's syndrome; most do not have a high sensitivity
	Easy bruising
	Facial plethora
	Proximal myopathy (or proximal muscle weakness)
	Striae (especially if reddish purple and > 1 cm wide)
	In children, weight gain with decreasing growth velocity
Cushing's syndrome features in the general population that are common and/or less discriminatory
Depression	Dorsocervical fat pad (“buffalo hump”)	Hypertension^b
Fatigue	Facial fullness	Incidental adrenal mass
Weight gain	Obesity	Vertebral osteoporosis^b
Back pain	Supraclavicular fullness	Polycystic ovary syndrome
Changes in appetite	Thin skin^b	Type 2 diabetes^b
Decreased concentration	Peripheral edema	Hypokalemia
Decreased libido	Acne	Kidney stones
Impaired memory (especially short term)	Hirsutism or female balding	Unusual infections
Insomnia	Poor skin healing
Irritability
Menstrual abnormalities
In children, slow growth	In children, abnormal genital virilization
	In children, short stature
	In children, pseudoprecocious puberty or delayed puberty

Symptoms	Signs	Overlapping conditions
Features that best discriminate Cushing's syndrome; most do not have a high sensitivity
	Easy bruising
	Facial plethora
	Proximal myopathy (or proximal muscle weakness)
	Striae (especially if reddish purple and > 1 cm wide)
	In children, weight gain with decreasing growth velocity
Cushing's syndrome features in the general population that are common and/or less discriminatory
Depression	Dorsocervical fat pad (“buffalo hump”)	Hypertension^b
Fatigue	Facial fullness	Incidental adrenal mass
Weight gain	Obesity	Vertebral osteoporosis^b
Back pain	Supraclavicular fullness	Polycystic ovary syndrome
Changes in appetite	Thin skin^b	Type 2 diabetes^b
Decreased concentration	Peripheral edema	Hypokalemia
Decreased libido	Acne	Kidney stones
Impaired memory (especially short term)	Hirsutism or female balding	Unusual infections
Insomnia	Poor skin healing
Irritability
Menstrual abnormalities
In children, slow growth	In children, abnormal genital virilization
	In children, short stature
	In children, pseudoprecocious puberty or delayed puberty

Features are listed in random order.

Cushing's syndrome is more likely if onset of the feature is at a younger age.

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