Table 4.

Measures for Prevention of Adrenal Crisis

Action PointIntervention
Identify and define the problemSteroid emergency card (check that card is available and up to date)
Medical alert bracelet or necklace: “Adrenal insufficiency – needs steroids!”
Educate patient (and partner/parents)Sick day rule 1: need to double the routine oral glucocorticoid dose when the patient experiences fever or illness requiring bed rest; when requiring antibiotics for an infection; or before a small outpatient procedure (eg, dental work)
Sick day rule 2: need to inject a glucocorticoid preparation im or iv in case of severe illness, trauma, persistent vomiting, when fasting for a procedure (colonoscopy!), or during surgical intervention.
100 mg hydrocortisone iv, im, or sc followed by 200 mg hydrocortisone per continuous iv infusion, alternatively repeated bolus doses (iv or im) every 6 h
    Give special attention to:Explaining the rationale for dose adjustment in stress/sickness
Discussing the situations requiring dose adjustment
Discussing symptoms and signs of emergent adrenal crisis
Teaching parenteral self-administration of glucocorticoid preparation
Enforcing the need to go to hospital after emergency injection
Provide patient with:Sufficient supply of hydrocortisone and fludrocortisone (accounting for possible sick days)
Hydrocortisone emergency injection kit prescription (vials of 100 mg hydrocortisone sodium, syringes, needles; alternatively, also hydrocortisone or prednisolone suppositories)
Leaflet with information on adrenal crisis and hospitalization to be shown to health care staff; clearly advise regarding the need to inject 100 mg hydrocortisone immediately iv or im, followed by continuous infusion of 200 mg/24 h
Emergency phone number of endocrine specialist team
Follow-upReinforce education and confirm understanding during each follow-up visit (at least annually in a patient without specific problems or recent crises; otherwise, more frequently)
Action PointIntervention
Identify and define the problemSteroid emergency card (check that card is available and up to date)
Medical alert bracelet or necklace: “Adrenal insufficiency – needs steroids!”
Educate patient (and partner/parents)Sick day rule 1: need to double the routine oral glucocorticoid dose when the patient experiences fever or illness requiring bed rest; when requiring antibiotics for an infection; or before a small outpatient procedure (eg, dental work)
Sick day rule 2: need to inject a glucocorticoid preparation im or iv in case of severe illness, trauma, persistent vomiting, when fasting for a procedure (colonoscopy!), or during surgical intervention.
100 mg hydrocortisone iv, im, or sc followed by 200 mg hydrocortisone per continuous iv infusion, alternatively repeated bolus doses (iv or im) every 6 h
    Give special attention to:Explaining the rationale for dose adjustment in stress/sickness
Discussing the situations requiring dose adjustment
Discussing symptoms and signs of emergent adrenal crisis
Teaching parenteral self-administration of glucocorticoid preparation
Enforcing the need to go to hospital after emergency injection
Provide patient with:Sufficient supply of hydrocortisone and fludrocortisone (accounting for possible sick days)
Hydrocortisone emergency injection kit prescription (vials of 100 mg hydrocortisone sodium, syringes, needles; alternatively, also hydrocortisone or prednisolone suppositories)
Leaflet with information on adrenal crisis and hospitalization to be shown to health care staff; clearly advise regarding the need to inject 100 mg hydrocortisone immediately iv or im, followed by continuous infusion of 200 mg/24 h
Emergency phone number of endocrine specialist team
Follow-upReinforce education and confirm understanding during each follow-up visit (at least annually in a patient without specific problems or recent crises; otherwise, more frequently)

Adapted from I. Bancos, et al: Diagnosis and management of adrenal insufficiency. Lancet Diabetes Endocrinol. 2015;3:216–226 (122), with permission. © Elsevier Limited.

Table 4.

Measures for Prevention of Adrenal Crisis

Action PointIntervention
Identify and define the problemSteroid emergency card (check that card is available and up to date)
Medical alert bracelet or necklace: “Adrenal insufficiency – needs steroids!”
Educate patient (and partner/parents)Sick day rule 1: need to double the routine oral glucocorticoid dose when the patient experiences fever or illness requiring bed rest; when requiring antibiotics for an infection; or before a small outpatient procedure (eg, dental work)
Sick day rule 2: need to inject a glucocorticoid preparation im or iv in case of severe illness, trauma, persistent vomiting, when fasting for a procedure (colonoscopy!), or during surgical intervention.
100 mg hydrocortisone iv, im, or sc followed by 200 mg hydrocortisone per continuous iv infusion, alternatively repeated bolus doses (iv or im) every 6 h
    Give special attention to:Explaining the rationale for dose adjustment in stress/sickness
Discussing the situations requiring dose adjustment
Discussing symptoms and signs of emergent adrenal crisis
Teaching parenteral self-administration of glucocorticoid preparation
Enforcing the need to go to hospital after emergency injection
Provide patient with:Sufficient supply of hydrocortisone and fludrocortisone (accounting for possible sick days)
Hydrocortisone emergency injection kit prescription (vials of 100 mg hydrocortisone sodium, syringes, needles; alternatively, also hydrocortisone or prednisolone suppositories)
Leaflet with information on adrenal crisis and hospitalization to be shown to health care staff; clearly advise regarding the need to inject 100 mg hydrocortisone immediately iv or im, followed by continuous infusion of 200 mg/24 h
Emergency phone number of endocrine specialist team
Follow-upReinforce education and confirm understanding during each follow-up visit (at least annually in a patient without specific problems or recent crises; otherwise, more frequently)
Action PointIntervention
Identify and define the problemSteroid emergency card (check that card is available and up to date)
Medical alert bracelet or necklace: “Adrenal insufficiency – needs steroids!”
Educate patient (and partner/parents)Sick day rule 1: need to double the routine oral glucocorticoid dose when the patient experiences fever or illness requiring bed rest; when requiring antibiotics for an infection; or before a small outpatient procedure (eg, dental work)
Sick day rule 2: need to inject a glucocorticoid preparation im or iv in case of severe illness, trauma, persistent vomiting, when fasting for a procedure (colonoscopy!), or during surgical intervention.
100 mg hydrocortisone iv, im, or sc followed by 200 mg hydrocortisone per continuous iv infusion, alternatively repeated bolus doses (iv or im) every 6 h
    Give special attention to:Explaining the rationale for dose adjustment in stress/sickness
Discussing the situations requiring dose adjustment
Discussing symptoms and signs of emergent adrenal crisis
Teaching parenteral self-administration of glucocorticoid preparation
Enforcing the need to go to hospital after emergency injection
Provide patient with:Sufficient supply of hydrocortisone and fludrocortisone (accounting for possible sick days)
Hydrocortisone emergency injection kit prescription (vials of 100 mg hydrocortisone sodium, syringes, needles; alternatively, also hydrocortisone or prednisolone suppositories)
Leaflet with information on adrenal crisis and hospitalization to be shown to health care staff; clearly advise regarding the need to inject 100 mg hydrocortisone immediately iv or im, followed by continuous infusion of 200 mg/24 h
Emergency phone number of endocrine specialist team
Follow-upReinforce education and confirm understanding during each follow-up visit (at least annually in a patient without specific problems or recent crises; otherwise, more frequently)

Adapted from I. Bancos, et al: Diagnosis and management of adrenal insufficiency. Lancet Diabetes Endocrinol. 2015;3:216–226 (122), with permission. © Elsevier Limited.

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