Table 2.
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Pneumocystis jirovecii Genotypes Obtained From Mitochondrial Large Subunit Ribosomal RNA, Superoxide Dismutase, and Cytochrome b and Sequences in 7 P. jirovecii Pneumonia Cases, 2 Colonized Patients, and 11 Unrelated Immunocompromised Control Patients

PatientSampleDateType of ImmunosuppressionmtLSUrRNACYBaSOD
Ctl1IS8 Jan 2015Immunosuppressive treatment1 + 2CYB1SOD1
Ctl2BAL22 Jan 2015LTR4CYB2SOD1
Ctl3BAL26 Jan 2015HIV3CYB1SOD1
Ctl4BAL5 Feb 2015Immunosuppressive treatment1CYB1SOD1
Ctl5BAL24 Feb 2015Immunosuppressive treatment1 + 2CYB1 + CYB7SOD1
Ctl6IS9 Mar 2015HIV1CYB1SOD2
Ctl7BAL21 Mar 2015LTR4CYB2SOD1
Ctl8BAL31 Mar 2015Immunosuppressive treatment + neoplasia1 + 4mixmix
Ctl9BAL13 Apr 2015Neoplasia2 + 3CYB1 + CYB2mix
Ctl10IS5 May 2015Immunosuppressive treatment + neoplasia3CYB6SOD1
Ctl11BAL7 May 2015Immunosuppressive treatmentmixmixmix
Case 1BAL17 Mar 2015HIV + RTR + HTR4CYB2
Case 2IS12 May 2015HTR4CYB2SOD1
Case 3BAL15 July 2015HTR4CYB2SOD1
Case 4BAL28 July 2015HTR4CYB2
Case 5BAL06 Aug 2015HTR4CYB2SOD1
Case 6BAL24 Aug 2015HTR4CYB2SOD1
Case 7BAL2 Sept 2015HTR4CYB2SOD1
Col 8NS31 Aug 2015HTR4CYB2SOD1
Col 9NS2 Sept 2015HTR4CYB2SOD1
Col 10NS31 Aug 2015HTRNAbNAbNAb
PatientSampleDateType of ImmunosuppressionmtLSUrRNACYBaSOD
Ctl1IS8 Jan 2015Immunosuppressive treatment1 + 2CYB1SOD1
Ctl2BAL22 Jan 2015LTR4CYB2SOD1
Ctl3BAL26 Jan 2015HIV3CYB1SOD1
Ctl4BAL5 Feb 2015Immunosuppressive treatment1CYB1SOD1
Ctl5BAL24 Feb 2015Immunosuppressive treatment1 + 2CYB1 + CYB7SOD1
Ctl6IS9 Mar 2015HIV1CYB1SOD2
Ctl7BAL21 Mar 2015LTR4CYB2SOD1
Ctl8BAL31 Mar 2015Immunosuppressive treatment + neoplasia1 + 4mixmix
Ctl9BAL13 Apr 2015Neoplasia2 + 3CYB1 + CYB2mix
Ctl10IS5 May 2015Immunosuppressive treatment + neoplasia3CYB6SOD1
Ctl11BAL7 May 2015Immunosuppressive treatmentmixmixmix
Case 1BAL17 Mar 2015HIV + RTR + HTR4CYB2
Case 2IS12 May 2015HTR4CYB2SOD1
Case 3BAL15 July 2015HTR4CYB2SOD1
Case 4BAL28 July 2015HTR4CYB2
Case 5BAL06 Aug 2015HTR4CYB2SOD1
Case 6BAL24 Aug 2015HTR4CYB2SOD1
Case 7BAL2 Sept 2015HTR4CYB2SOD1
Col 8NS31 Aug 2015HTR4CYB2SOD1
Col 9NS2 Sept 2015HTR4CYB2SOD1
Col 10NS31 Aug 2015HTRNAbNAbNAb

Abbreviations: BAL, bronchoalveolar lavage; Ctl, control patient; Col, colonized patient; CYB, cytochrome b; HIV, human immunodeficiency virus; HTR, heart transplant recipient; IS, induced sputum; LTR, liver transplant recipient; mtLSUrRNA, mitochondrial large subunit ribosomal RNA; NA, not available; NS, nasopharyngeal swab; RTR, renal transplant recipient; SOD, superoxide dismutase.

aThe 9 HTR patients harbored a previously unreported C350T mutation at the CYB gene, whereas none of the control patients harbored this punctual mutation.

bThe absence of genotyping data was due to genotype analysis failure for patient 10 (Col 10).

Table 2.
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Pneumocystis jirovecii Genotypes Obtained From Mitochondrial Large Subunit Ribosomal RNA, Superoxide Dismutase, and Cytochrome b and Sequences in 7 P. jirovecii Pneumonia Cases, 2 Colonized Patients, and 11 Unrelated Immunocompromised Control Patients

PatientSampleDateType of ImmunosuppressionmtLSUrRNACYBaSOD
Ctl1IS8 Jan 2015Immunosuppressive treatment1 + 2CYB1SOD1
Ctl2BAL22 Jan 2015LTR4CYB2SOD1
Ctl3BAL26 Jan 2015HIV3CYB1SOD1
Ctl4BAL5 Feb 2015Immunosuppressive treatment1CYB1SOD1
Ctl5BAL24 Feb 2015Immunosuppressive treatment1 + 2CYB1 + CYB7SOD1
Ctl6IS9 Mar 2015HIV1CYB1SOD2
Ctl7BAL21 Mar 2015LTR4CYB2SOD1
Ctl8BAL31 Mar 2015Immunosuppressive treatment + neoplasia1 + 4mixmix
Ctl9BAL13 Apr 2015Neoplasia2 + 3CYB1 + CYB2mix
Ctl10IS5 May 2015Immunosuppressive treatment + neoplasia3CYB6SOD1
Ctl11BAL7 May 2015Immunosuppressive treatmentmixmixmix
Case 1BAL17 Mar 2015HIV + RTR + HTR4CYB2
Case 2IS12 May 2015HTR4CYB2SOD1
Case 3BAL15 July 2015HTR4CYB2SOD1
Case 4BAL28 July 2015HTR4CYB2
Case 5BAL06 Aug 2015HTR4CYB2SOD1
Case 6BAL24 Aug 2015HTR4CYB2SOD1
Case 7BAL2 Sept 2015HTR4CYB2SOD1
Col 8NS31 Aug 2015HTR4CYB2SOD1
Col 9NS2 Sept 2015HTR4CYB2SOD1
Col 10NS31 Aug 2015HTRNAbNAbNAb
PatientSampleDateType of ImmunosuppressionmtLSUrRNACYBaSOD
Ctl1IS8 Jan 2015Immunosuppressive treatment1 + 2CYB1SOD1
Ctl2BAL22 Jan 2015LTR4CYB2SOD1
Ctl3BAL26 Jan 2015HIV3CYB1SOD1
Ctl4BAL5 Feb 2015Immunosuppressive treatment1CYB1SOD1
Ctl5BAL24 Feb 2015Immunosuppressive treatment1 + 2CYB1 + CYB7SOD1
Ctl6IS9 Mar 2015HIV1CYB1SOD2
Ctl7BAL21 Mar 2015LTR4CYB2SOD1
Ctl8BAL31 Mar 2015Immunosuppressive treatment + neoplasia1 + 4mixmix
Ctl9BAL13 Apr 2015Neoplasia2 + 3CYB1 + CYB2mix
Ctl10IS5 May 2015Immunosuppressive treatment + neoplasia3CYB6SOD1
Ctl11BAL7 May 2015Immunosuppressive treatmentmixmixmix
Case 1BAL17 Mar 2015HIV + RTR + HTR4CYB2
Case 2IS12 May 2015HTR4CYB2SOD1
Case 3BAL15 July 2015HTR4CYB2SOD1
Case 4BAL28 July 2015HTR4CYB2
Case 5BAL06 Aug 2015HTR4CYB2SOD1
Case 6BAL24 Aug 2015HTR4CYB2SOD1
Case 7BAL2 Sept 2015HTR4CYB2SOD1
Col 8NS31 Aug 2015HTR4CYB2SOD1
Col 9NS2 Sept 2015HTR4CYB2SOD1
Col 10NS31 Aug 2015HTRNAbNAbNAb

Abbreviations: BAL, bronchoalveolar lavage; Ctl, control patient; Col, colonized patient; CYB, cytochrome b; HIV, human immunodeficiency virus; HTR, heart transplant recipient; IS, induced sputum; LTR, liver transplant recipient; mtLSUrRNA, mitochondrial large subunit ribosomal RNA; NA, not available; NS, nasopharyngeal swab; RTR, renal transplant recipient; SOD, superoxide dismutase.

aThe 9 HTR patients harbored a previously unreported C350T mutation at the CYB gene, whereas none of the control patients harbored this punctual mutation.

bThe absence of genotyping data was due to genotype analysis failure for patient 10 (Col 10).

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