Correlations between Change from Baseline to Week 28 (QLS, CGI-S, WoRQ, TooL, SWN-S) or Scores at Week 28 (IAQ, CGI-I) by Treatment
| Correlation Estimates . | QLS Total . | CGI-S . | IAQ Total . | CGI-I . | WoRQ Total . | TooL Total . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . |
| CGI-S | -0.598 | -0.381 | ||||||||||
| IAQ-total | -0.587 | -0.510 | 0.392 | 0.473 | ||||||||
| CGI-I | -0.459 | -0.400 | 0.765 | 0.715 | 0.459 | 0.578 | ||||||
| WoRQ-total | -0.322 | -0.396 | 0.468 | 0.236 | 0.260 | 0.181 | 0.380 | 0.333 | ||||
| TooL total | -0.374 | -0.365 | 0.323 | 0.213 | 0.355 | 0.058 | 0.491 | 0.168 | 0.117 | -0.158 | ||
| SWN-S total | 0.375 | 0.376 | -0.390 | -0.355 | -0.330 | -0.259 | -0.260 | -0.348 | -0.113 | -0.064 | -0.689 | -0.557 |
| Correlation Estimates . | QLS Total . | CGI-S . | IAQ Total . | CGI-I . | WoRQ Total . | TooL Total . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . |
| CGI-S | -0.598 | -0.381 | ||||||||||
| IAQ-total | -0.587 | -0.510 | 0.392 | 0.473 | ||||||||
| CGI-I | -0.459 | -0.400 | 0.765 | 0.715 | 0.459 | 0.578 | ||||||
| WoRQ-total | -0.322 | -0.396 | 0.468 | 0.236 | 0.260 | 0.181 | 0.380 | 0.333 | ||||
| TooL total | -0.374 | -0.365 | 0.323 | 0.213 | 0.355 | 0.058 | 0.491 | 0.168 | 0.117 | -0.158 | ||
| SWN-S total | 0.375 | 0.376 | -0.390 | -0.355 | -0.330 | -0.259 | -0.260 | -0.348 | -0.113 | -0.064 | -0.689 | -0.557 |
Analyzed posthoc at patient level with MMRM to assess partial correlations between scales in the full analysis set. Abbreviations: CGI-I, Clinical Global Impression–Improvement; CGI-S, CGI–Severity; IAQ, Investigators’ Assessment Questionnaire; MMRM, mixed model for repeated measures; QLS, Heinrichs-Carpenter Quality of Life Scale; SWN-S, Subjective Well-Being Under Neuroleptic Treatment−short version; Tool, Tolerability and Quality of Life Questionnaire; WoRQ, Work Readiness Questionnaire.
Higher QLS and SWN-S total scores indicate clinical improvements, whereas lower CGI-S, IAQ, CGI-I, WoRQ, and TooL scores indicate better clinical condition.
Correlations between Change from Baseline to Week 28 (QLS, CGI-S, WoRQ, TooL, SWN-S) or Scores at Week 28 (IAQ, CGI-I) by Treatment
| Correlation Estimates . | QLS Total . | CGI-S . | IAQ Total . | CGI-I . | WoRQ Total . | TooL Total . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . |
| CGI-S | -0.598 | -0.381 | ||||||||||
| IAQ-total | -0.587 | -0.510 | 0.392 | 0.473 | ||||||||
| CGI-I | -0.459 | -0.400 | 0.765 | 0.715 | 0.459 | 0.578 | ||||||
| WoRQ-total | -0.322 | -0.396 | 0.468 | 0.236 | 0.260 | 0.181 | 0.380 | 0.333 | ||||
| TooL total | -0.374 | -0.365 | 0.323 | 0.213 | 0.355 | 0.058 | 0.491 | 0.168 | 0.117 | -0.158 | ||
| SWN-S total | 0.375 | 0.376 | -0.390 | -0.355 | -0.330 | -0.259 | -0.260 | -0.348 | -0.113 | -0.064 | -0.689 | -0.557 |
| Correlation Estimates . | QLS Total . | CGI-S . | IAQ Total . | CGI-I . | WoRQ Total . | TooL Total . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . | AOM 400 . | PP . |
| CGI-S | -0.598 | -0.381 | ||||||||||
| IAQ-total | -0.587 | -0.510 | 0.392 | 0.473 | ||||||||
| CGI-I | -0.459 | -0.400 | 0.765 | 0.715 | 0.459 | 0.578 | ||||||
| WoRQ-total | -0.322 | -0.396 | 0.468 | 0.236 | 0.260 | 0.181 | 0.380 | 0.333 | ||||
| TooL total | -0.374 | -0.365 | 0.323 | 0.213 | 0.355 | 0.058 | 0.491 | 0.168 | 0.117 | -0.158 | ||
| SWN-S total | 0.375 | 0.376 | -0.390 | -0.355 | -0.330 | -0.259 | -0.260 | -0.348 | -0.113 | -0.064 | -0.689 | -0.557 |
Analyzed posthoc at patient level with MMRM to assess partial correlations between scales in the full analysis set. Abbreviations: CGI-I, Clinical Global Impression–Improvement; CGI-S, CGI–Severity; IAQ, Investigators’ Assessment Questionnaire; MMRM, mixed model for repeated measures; QLS, Heinrichs-Carpenter Quality of Life Scale; SWN-S, Subjective Well-Being Under Neuroleptic Treatment−short version; Tool, Tolerability and Quality of Life Questionnaire; WoRQ, Work Readiness Questionnaire.
Higher QLS and SWN-S total scores indicate clinical improvements, whereas lower CGI-S, IAQ, CGI-I, WoRQ, and TooL scores indicate better clinical condition.
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