| Organism . | Types of protocol used . | Selective conditions(s) . | Main finding . | Reference . |
|---|---|---|---|---|
| Lactococcus lactis | Serial propagation | Starvation/growth, aerated/not shaken | IS element-mediated mutations are frequently occurring | de Visser et al. (2004) |
| Lactococcus lactis | Serial propagation | Plant isolate adapted to growth in milk | Genome erosion; importance of nitrogen metabolism for growth in milk; one mutator strains identified | Bachmann et al. (2011) |
| Lactobacillus rhamnosus | Serial propagation | Salt, bile and shear stress | Chromosomal rearrangements and mutator strains were identified | Douillard et al. (2016) |
| Lactococcus lactis | Serial propagation | Fast growing variants of ldh deletion mutant were selected | IS981 activated the ldhB gene which lead to switch from mixed acid fermentation to homolactic fermentation | Bongers et al. (2003) |
| Lactobacillus plantarum | Serial propagation | Surviving passage of the murine gastro intestinal tract | Repetitive rounds of exposure to mouse GIT resulted in higher GIT survival rates | van Bokhorst-van de Veen et al. (2013) |
| Lactococcus lactis | Serial propagation (unintentional selection) | ldh deletion mutant showed unexpectedly homolactic metabolism; ldh-positive variant was probably selected unintentionally during propagation after strain construction (see also Bongers et al.2003) | IS905 activated ldhB gene and lead to switch from mixed acid fermentation to homolactic fermentation | Gaspar et al. (2007) |
| Lactococcus lactis | Dominant selection | Growth of MG1363 (lac- strain) on lactose | Upregulation of cellobiose PTS allows growth on lactose | Solopova et al. (2012) |
| Lactococcus lactis | Dominant selection | Growth on medium containing H2O2 | Isolation of SpOx mutants (spontaneous oxidative stress resistant) | Rochat et al. (2005) |
| Lactococcus lactis | Dominant selection | Growth at elevated temperature | Mutation in c-di-AMP specific phosphodiesterase leads to heat resistance and salt hypersensitivity | Smith et al. (2012) |
| Lactobacillus helveticus | Dominant selection | Growth at elevated temperature | Increased growth rate at elevated temperature lead to increased autolysis under cheese-like conditions | Spus et al. (2017) |
| Lactococcus lactis | Emulsion propagation | Selection for a high number of offspring | Selection for cell yield resulted in slow growing cells with high biomass yield and mixed acid fermentation | Bachmann et al. (2013) |
| Lactococcus lactis | Chemostat | Carbon limitation at various dilution rates | Mutations in ccpA, a global regulator of carbon metabolism, were found across different conditions | Price et al. (2010, unpublished) |
| Organism . | Types of protocol used . | Selective conditions(s) . | Main finding . | Reference . |
|---|---|---|---|---|
| Lactococcus lactis | Serial propagation | Starvation/growth, aerated/not shaken | IS element-mediated mutations are frequently occurring | de Visser et al. (2004) |
| Lactococcus lactis | Serial propagation | Plant isolate adapted to growth in milk | Genome erosion; importance of nitrogen metabolism for growth in milk; one mutator strains identified | Bachmann et al. (2011) |
| Lactobacillus rhamnosus | Serial propagation | Salt, bile and shear stress | Chromosomal rearrangements and mutator strains were identified | Douillard et al. (2016) |
| Lactococcus lactis | Serial propagation | Fast growing variants of ldh deletion mutant were selected | IS981 activated the ldhB gene which lead to switch from mixed acid fermentation to homolactic fermentation | Bongers et al. (2003) |
| Lactobacillus plantarum | Serial propagation | Surviving passage of the murine gastro intestinal tract | Repetitive rounds of exposure to mouse GIT resulted in higher GIT survival rates | van Bokhorst-van de Veen et al. (2013) |
| Lactococcus lactis | Serial propagation (unintentional selection) | ldh deletion mutant showed unexpectedly homolactic metabolism; ldh-positive variant was probably selected unintentionally during propagation after strain construction (see also Bongers et al.2003) | IS905 activated ldhB gene and lead to switch from mixed acid fermentation to homolactic fermentation | Gaspar et al. (2007) |
| Lactococcus lactis | Dominant selection | Growth of MG1363 (lac- strain) on lactose | Upregulation of cellobiose PTS allows growth on lactose | Solopova et al. (2012) |
| Lactococcus lactis | Dominant selection | Growth on medium containing H2O2 | Isolation of SpOx mutants (spontaneous oxidative stress resistant) | Rochat et al. (2005) |
| Lactococcus lactis | Dominant selection | Growth at elevated temperature | Mutation in c-di-AMP specific phosphodiesterase leads to heat resistance and salt hypersensitivity | Smith et al. (2012) |
| Lactobacillus helveticus | Dominant selection | Growth at elevated temperature | Increased growth rate at elevated temperature lead to increased autolysis under cheese-like conditions | Spus et al. (2017) |
| Lactococcus lactis | Emulsion propagation | Selection for a high number of offspring | Selection for cell yield resulted in slow growing cells with high biomass yield and mixed acid fermentation | Bachmann et al. (2013) |
| Lactococcus lactis | Chemostat | Carbon limitation at various dilution rates | Mutations in ccpA, a global regulator of carbon metabolism, were found across different conditions | Price et al. (2010, unpublished) |
| Organism . | Types of protocol used . | Selective conditions(s) . | Main finding . | Reference . |
|---|---|---|---|---|
| Lactococcus lactis | Serial propagation | Starvation/growth, aerated/not shaken | IS element-mediated mutations are frequently occurring | de Visser et al. (2004) |
| Lactococcus lactis | Serial propagation | Plant isolate adapted to growth in milk | Genome erosion; importance of nitrogen metabolism for growth in milk; one mutator strains identified | Bachmann et al. (2011) |
| Lactobacillus rhamnosus | Serial propagation | Salt, bile and shear stress | Chromosomal rearrangements and mutator strains were identified | Douillard et al. (2016) |
| Lactococcus lactis | Serial propagation | Fast growing variants of ldh deletion mutant were selected | IS981 activated the ldhB gene which lead to switch from mixed acid fermentation to homolactic fermentation | Bongers et al. (2003) |
| Lactobacillus plantarum | Serial propagation | Surviving passage of the murine gastro intestinal tract | Repetitive rounds of exposure to mouse GIT resulted in higher GIT survival rates | van Bokhorst-van de Veen et al. (2013) |
| Lactococcus lactis | Serial propagation (unintentional selection) | ldh deletion mutant showed unexpectedly homolactic metabolism; ldh-positive variant was probably selected unintentionally during propagation after strain construction (see also Bongers et al.2003) | IS905 activated ldhB gene and lead to switch from mixed acid fermentation to homolactic fermentation | Gaspar et al. (2007) |
| Lactococcus lactis | Dominant selection | Growth of MG1363 (lac- strain) on lactose | Upregulation of cellobiose PTS allows growth on lactose | Solopova et al. (2012) |
| Lactococcus lactis | Dominant selection | Growth on medium containing H2O2 | Isolation of SpOx mutants (spontaneous oxidative stress resistant) | Rochat et al. (2005) |
| Lactococcus lactis | Dominant selection | Growth at elevated temperature | Mutation in c-di-AMP specific phosphodiesterase leads to heat resistance and salt hypersensitivity | Smith et al. (2012) |
| Lactobacillus helveticus | Dominant selection | Growth at elevated temperature | Increased growth rate at elevated temperature lead to increased autolysis under cheese-like conditions | Spus et al. (2017) |
| Lactococcus lactis | Emulsion propagation | Selection for a high number of offspring | Selection for cell yield resulted in slow growing cells with high biomass yield and mixed acid fermentation | Bachmann et al. (2013) |
| Lactococcus lactis | Chemostat | Carbon limitation at various dilution rates | Mutations in ccpA, a global regulator of carbon metabolism, were found across different conditions | Price et al. (2010, unpublished) |
| Organism . | Types of protocol used . | Selective conditions(s) . | Main finding . | Reference . |
|---|---|---|---|---|
| Lactococcus lactis | Serial propagation | Starvation/growth, aerated/not shaken | IS element-mediated mutations are frequently occurring | de Visser et al. (2004) |
| Lactococcus lactis | Serial propagation | Plant isolate adapted to growth in milk | Genome erosion; importance of nitrogen metabolism for growth in milk; one mutator strains identified | Bachmann et al. (2011) |
| Lactobacillus rhamnosus | Serial propagation | Salt, bile and shear stress | Chromosomal rearrangements and mutator strains were identified | Douillard et al. (2016) |
| Lactococcus lactis | Serial propagation | Fast growing variants of ldh deletion mutant were selected | IS981 activated the ldhB gene which lead to switch from mixed acid fermentation to homolactic fermentation | Bongers et al. (2003) |
| Lactobacillus plantarum | Serial propagation | Surviving passage of the murine gastro intestinal tract | Repetitive rounds of exposure to mouse GIT resulted in higher GIT survival rates | van Bokhorst-van de Veen et al. (2013) |
| Lactococcus lactis | Serial propagation (unintentional selection) | ldh deletion mutant showed unexpectedly homolactic metabolism; ldh-positive variant was probably selected unintentionally during propagation after strain construction (see also Bongers et al.2003) | IS905 activated ldhB gene and lead to switch from mixed acid fermentation to homolactic fermentation | Gaspar et al. (2007) |
| Lactococcus lactis | Dominant selection | Growth of MG1363 (lac- strain) on lactose | Upregulation of cellobiose PTS allows growth on lactose | Solopova et al. (2012) |
| Lactococcus lactis | Dominant selection | Growth on medium containing H2O2 | Isolation of SpOx mutants (spontaneous oxidative stress resistant) | Rochat et al. (2005) |
| Lactococcus lactis | Dominant selection | Growth at elevated temperature | Mutation in c-di-AMP specific phosphodiesterase leads to heat resistance and salt hypersensitivity | Smith et al. (2012) |
| Lactobacillus helveticus | Dominant selection | Growth at elevated temperature | Increased growth rate at elevated temperature lead to increased autolysis under cheese-like conditions | Spus et al. (2017) |
| Lactococcus lactis | Emulsion propagation | Selection for a high number of offspring | Selection for cell yield resulted in slow growing cells with high biomass yield and mixed acid fermentation | Bachmann et al. (2013) |
| Lactococcus lactis | Chemostat | Carbon limitation at various dilution rates | Mutations in ccpA, a global regulator of carbon metabolism, were found across different conditions | Price et al. (2010, unpublished) |
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