Table 4. Open in new tab...

Table 4.

Multivariable-Adjusted OR (95% CI) for Worsening Frailty Phenotype Associated With Baseline Hormonal Predictor: Models and Adjustments

Baseline Parameter	N
		Model 1: Baseline Frailty			Model 2: Baseline Frailty and Age			Model 3: Baseline Frailty, Age, and Center			Model 4: Baseline Frailty, Age, Center, and BMI
		OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value
IGF-1	1885	0.77	0.68, 0.86	<0.001	0.85	0.75, 0.96	0.008	0.82	0.73, 0.93	0.002	0.82	0.73, 0.93	0.002
IGFBP-3	1888	0.81	0.73, 0.90	<0.001	0.90	0.80, 1.01	0.070	0.84	0.74, 0.94	0.003	0.84	0.75, 0.95	0.006
DHEA-S	1891	0.87	0.78, 0.97	0.012	1.07	0.95, 1.22	0.259	1.07	0.94, 1.21	0.299	1.06	0.93, 1.20	0.390
PTH^a	1890	1.05	0.95, 1.16	0.329	1.03	0.93, 1.14	0.588	1.00	0.90, 1.12	0.938	1.01	0.90, 1.13	0.860
25OHD^b	1828	0.92	0.83, 1.03	0.162	0.89	0.80, 1.00	0.053	0.86	0.76, 0.97	0.013	0.84	0.75, 0.95	0.007

Baseline Parameter	N
		Model 1: Baseline Frailty			Model 2: Baseline Frailty and Age			Model 3: Baseline Frailty, Age, and Center			Model 4: Baseline Frailty, Age, Center, and BMI
		OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value	OR	95% CI	P Value
IGF-1	1885	0.77	0.68, 0.86	<0.001	0.85	0.75, 0.96	0.008	0.82	0.73, 0.93	0.002	0.82	0.73, 0.93	0.002
IGFBP-3	1888	0.81	0.73, 0.90	<0.001	0.90	0.80, 1.01	0.070	0.84	0.74, 0.94	0.003	0.84	0.75, 0.95	0.006
DHEA-S	1891	0.87	0.78, 0.97	0.012	1.07	0.95, 1.22	0.259	1.07	0.94, 1.21	0.299	1.06	0.93, 1.20	0.390
PTH^a	1890	1.05	0.95, 1.16	0.329	1.03	0.93, 1.14	0.588	1.00	0.90, 1.12	0.938	1.01	0.90, 1.13	0.860
25OHD^b	1828	0.92	0.83, 1.03	0.162	0.89	0.80, 1.00	0.053	0.86	0.76, 0.97	0.013	0.84	0.75, 0.95	0.007

Models 3 and 4 additionally adjusted for baseline 25OHD level.

Models 3 and 4 additionally adjusted for baseline PTH level.