Table 1.
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Classification of Pituitary Hormone–Dependent Sex-Biased Genes

ClassNumber of Genes (%)Response in MHxResponse in FHxGene SubclassNumber of GenesExamples
Male class I152 (78)Down—IA83Ces2b, Pitx3, Mup20
DownDownIB65Ugt2b38, Cyp7b1, Elovl3
DownUpIC4Cyp2d9, Cyp4a12b
Male class II43 (22)—UpIIA29Cyp4a12a, Nox4, Sstr2
UpUpIIB14Serpina7, Susd4, Snhg11
Female class I84 (38)—DownIA48Cyp3a16, Fmo3, A1bg, Cux2
DownDownIB24Cyp3a41a, Cyp2c69, Cyp2c40
UpDownIC12Sult3a1, Sult2a1, Cyp2a4
Female class II138 (62)Up—IIA101Sult2a5, Cyp2b9, Hao2
UpUpIIB37Sult2a6, Cyp2b13, Acot3
ClassNumber of Genes (%)Response in MHxResponse in FHxGene SubclassNumber of GenesExamples
Male class I152 (78)Down—IA83Ces2b, Pitx3, Mup20
DownDownIB65Ugt2b38, Cyp7b1, Elovl3
DownUpIC4Cyp2d9, Cyp4a12b
Male class II43 (22)—UpIIA29Cyp4a12a, Nox4, Sstr2
UpUpIIB14Serpina7, Susd4, Snhg11
Female class I84 (38)—DownIA48Cyp3a16, Fmo3, A1bg, Cux2
DownDownIB24Cyp3a41a, Cyp2c69, Cyp2c40
UpDownIC12Sult3a1, Sult2a1, Cyp2a4
Female class II138 (62)Up—IIA101Sult2a5, Cyp2b9, Hao2
UpUpIIB37Sult2a6, Cyp2b13, Acot3

Of 530 sex-biased genes, 417 respond to hypophysectomy at |fold change| > 2 and an adjusted P value of <0.05 in either male or female mouse liver. Those genes are classified based on their response to hypophysectomy in male and female liver, as shown. Class I sex-biased genes are those that are downregulated by hypophysectomy in the sex where they show the higher expression in intact mice. Class II sex-biased genes are those that are upregulated by hypophysectomy in the sex where they show the lower expression in intact mice. Subclasses A, B, and C indicate the response to hypophysectomy in the dominant sex (class II genes) or in the opposite sex (class I genes), as indicated. See Supplemental Table 3 for a complete listing of genes.

Abbreviations: FHx, hypophysectomized female; MHx, hypophysectomized male; —, no significant change in expression.

Table 1.
Open in new tab

Classification of Pituitary Hormone–Dependent Sex-Biased Genes

ClassNumber of Genes (%)Response in MHxResponse in FHxGene SubclassNumber of GenesExamples
Male class I152 (78)Down—IA83Ces2b, Pitx3, Mup20
DownDownIB65Ugt2b38, Cyp7b1, Elovl3
DownUpIC4Cyp2d9, Cyp4a12b
Male class II43 (22)—UpIIA29Cyp4a12a, Nox4, Sstr2
UpUpIIB14Serpina7, Susd4, Snhg11
Female class I84 (38)—DownIA48Cyp3a16, Fmo3, A1bg, Cux2
DownDownIB24Cyp3a41a, Cyp2c69, Cyp2c40
UpDownIC12Sult3a1, Sult2a1, Cyp2a4
Female class II138 (62)Up—IIA101Sult2a5, Cyp2b9, Hao2
UpUpIIB37Sult2a6, Cyp2b13, Acot3
ClassNumber of Genes (%)Response in MHxResponse in FHxGene SubclassNumber of GenesExamples
Male class I152 (78)Down—IA83Ces2b, Pitx3, Mup20
DownDownIB65Ugt2b38, Cyp7b1, Elovl3
DownUpIC4Cyp2d9, Cyp4a12b
Male class II43 (22)—UpIIA29Cyp4a12a, Nox4, Sstr2
UpUpIIB14Serpina7, Susd4, Snhg11
Female class I84 (38)—DownIA48Cyp3a16, Fmo3, A1bg, Cux2
DownDownIB24Cyp3a41a, Cyp2c69, Cyp2c40
UpDownIC12Sult3a1, Sult2a1, Cyp2a4
Female class II138 (62)Up—IIA101Sult2a5, Cyp2b9, Hao2
UpUpIIB37Sult2a6, Cyp2b13, Acot3

Of 530 sex-biased genes, 417 respond to hypophysectomy at |fold change| > 2 and an adjusted P value of <0.05 in either male or female mouse liver. Those genes are classified based on their response to hypophysectomy in male and female liver, as shown. Class I sex-biased genes are those that are downregulated by hypophysectomy in the sex where they show the higher expression in intact mice. Class II sex-biased genes are those that are upregulated by hypophysectomy in the sex where they show the lower expression in intact mice. Subclasses A, B, and C indicate the response to hypophysectomy in the dominant sex (class II genes) or in the opposite sex (class I genes), as indicated. See Supplemental Table 3 for a complete listing of genes.

Abbreviations: FHx, hypophysectomized female; MHx, hypophysectomized male; —, no significant change in expression.

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