Association of the lead variants at 18 newly identified loci with natural log transformed plasma fibrinogen concentration (g/l)
| Locus . | Variant . | Position . | Closest gene . | eQTL . | NSYN variants . | A1/A2 . | Frequency . | β . | P-values . |
|---|---|---|---|---|---|---|---|---|---|
| 2p25.3 | rs7588285 | 3 648 186 | COLEC11 | C/G | 0.20 | 0.0074 | 1.2 × 10−08 | ||
| 3p25.3 | rs62246343 | 9 543 642 | LHFPL4 | T/C | 0.17 | 0.0071 | 2.2 × 10−08 | ||
| 3q21.1 | rs1976714 | 122 864 771 | PDIA5 | T/G | 0.35 | −0.0055 | 2.3 × 10−08 | ||
| 3q21.3 | 3:129228166 | 129 228 166 | IFT122 | RPL32P3 | D/R | 0.10 | 0.009 | 1.0 × 10−08 | |
| 7p14.2 | rs2710804 | 36 084 529 | EEPD1 | C/T | 0.37 | 0.0055 | 2.9 × 10−09 | ||
| 7q36.1 | 7:150289652 | 150 289 652 | GIMAP4 | GIMAP4 | D/R | 0.21 | −0.0073 | 9.3 × 10−11 | |
| 8p23.1 | rs7012814 | 9 173 358 | LOC157273 | A/G | 0.47 | 0.0060 | 2.1 × 10−10 | ||
| 9q22.2 | rs3138493 | 92 219 260 | GADD45G | SEMA4D | T/C | 0.48 | −0.0054 | 2.5 × 10−09 | |
| 10q23.31 | rs2250644 | 91 008 879 | LIPA | T/C | 0.33 | 0.0054 | 2.2 × 10−08 | ||
| 10q26.13 | rs2420915 | 122 840 277 | MIR5694 | WDR11 | A/G | 0.09 | −0.0094 | 5.2 × 10−09 | |
| 11p12 | rs7934094 | 43 505 707 | TTC17 | G/T | 0.22 | −0.0083 | 2.5 × 10−13 | ||
| 12p12.1 | 12:21703935 | 21 703 935 | GYS2 | R/D | 0.37 | 0.0062 | 8.4 × 10−09 | ||
| 12q24.12 | rs7310615 | 111 865 049 | SH2B3 | SH2B3 | SH2B3 | C/G | 0.50 | −0.0069 | 1.5 × 10−13 |
| 15q15.1 | rs56702977 | 42 671 308 | CAPN3 | ZFP106 | A/G | 0.13 | 0.0080 | 2.1 × 10−09 | |
| 16p11.2 | 16:28845027 | 28 845 027 | ATXN2L | TUFM | D/R | 0.39 | 0.0061 | 7.7 × 10−10 | |
| 16q22.2 | rs1035560 | 72 032 730 | PKD1L3 | HP | C/T | 0.40 | 0.0064 | 2.6 × 10−12 | |
| 17q21.2 | rs7224737 | 40 289 364 | RAB5C | STAT3 | HSPB9 | A/G | 0.24 | 0.0061 | 6.1 × 10−09 |
| 19q13.33 | rs73058052 | 50 099 422 | PRR12 | IRF3 | PRRG2 | T/C | 0.16 | 0.0074 | 2.0 × 10−08 |
| Locus . | Variant . | Position . | Closest gene . | eQTL . | NSYN variants . | A1/A2 . | Frequency . | β . | P-values . |
|---|---|---|---|---|---|---|---|---|---|
| 2p25.3 | rs7588285 | 3 648 186 | COLEC11 | C/G | 0.20 | 0.0074 | 1.2 × 10−08 | ||
| 3p25.3 | rs62246343 | 9 543 642 | LHFPL4 | T/C | 0.17 | 0.0071 | 2.2 × 10−08 | ||
| 3q21.1 | rs1976714 | 122 864 771 | PDIA5 | T/G | 0.35 | −0.0055 | 2.3 × 10−08 | ||
| 3q21.3 | 3:129228166 | 129 228 166 | IFT122 | RPL32P3 | D/R | 0.10 | 0.009 | 1.0 × 10−08 | |
| 7p14.2 | rs2710804 | 36 084 529 | EEPD1 | C/T | 0.37 | 0.0055 | 2.9 × 10−09 | ||
| 7q36.1 | 7:150289652 | 150 289 652 | GIMAP4 | GIMAP4 | D/R | 0.21 | −0.0073 | 9.3 × 10−11 | |
| 8p23.1 | rs7012814 | 9 173 358 | LOC157273 | A/G | 0.47 | 0.0060 | 2.1 × 10−10 | ||
| 9q22.2 | rs3138493 | 92 219 260 | GADD45G | SEMA4D | T/C | 0.48 | −0.0054 | 2.5 × 10−09 | |
| 10q23.31 | rs2250644 | 91 008 879 | LIPA | T/C | 0.33 | 0.0054 | 2.2 × 10−08 | ||
| 10q26.13 | rs2420915 | 122 840 277 | MIR5694 | WDR11 | A/G | 0.09 | −0.0094 | 5.2 × 10−09 | |
| 11p12 | rs7934094 | 43 505 707 | TTC17 | G/T | 0.22 | −0.0083 | 2.5 × 10−13 | ||
| 12p12.1 | 12:21703935 | 21 703 935 | GYS2 | R/D | 0.37 | 0.0062 | 8.4 × 10−09 | ||
| 12q24.12 | rs7310615 | 111 865 049 | SH2B3 | SH2B3 | SH2B3 | C/G | 0.50 | −0.0069 | 1.5 × 10−13 |
| 15q15.1 | rs56702977 | 42 671 308 | CAPN3 | ZFP106 | A/G | 0.13 | 0.0080 | 2.1 × 10−09 | |
| 16p11.2 | 16:28845027 | 28 845 027 | ATXN2L | TUFM | D/R | 0.39 | 0.0061 | 7.7 × 10−10 | |
| 16q22.2 | rs1035560 | 72 032 730 | PKD1L3 | HP | C/T | 0.40 | 0.0064 | 2.6 × 10−12 | |
| 17q21.2 | rs7224737 | 40 289 364 | RAB5C | STAT3 | HSPB9 | A/G | 0.24 | 0.0061 | 6.1 × 10−09 |
| 19q13.33 | rs73058052 | 50 099 422 | PRR12 | IRF3 | PRRG2 | T/C | 0.16 | 0.0074 | 2.0 × 10−08 |
eQTL indicates the gene with the strongest significant association between its expression levels in blood and the lead variant or its proxy. NSYN variants indicates genes containing non-synonymous variant correlated to the lead variant (R2 > 0.9). A1 indicates the coded allele. A2 indicates the other allele. Frequency is the frequency of the coded allele. β indicates the β-coefficient adjusted for age, sex, population structure and study-specific covariates, such as center or case/control status. The β-coefficient can be interpreted as the ln(g/l) change in fibrinogen per 1 unit change in the dosage of the coded allele.
Association of the lead variants at 18 newly identified loci with natural log transformed plasma fibrinogen concentration (g/l)
| Locus . | Variant . | Position . | Closest gene . | eQTL . | NSYN variants . | A1/A2 . | Frequency . | β . | P-values . |
|---|---|---|---|---|---|---|---|---|---|
| 2p25.3 | rs7588285 | 3 648 186 | COLEC11 | C/G | 0.20 | 0.0074 | 1.2 × 10−08 | ||
| 3p25.3 | rs62246343 | 9 543 642 | LHFPL4 | T/C | 0.17 | 0.0071 | 2.2 × 10−08 | ||
| 3q21.1 | rs1976714 | 122 864 771 | PDIA5 | T/G | 0.35 | −0.0055 | 2.3 × 10−08 | ||
| 3q21.3 | 3:129228166 | 129 228 166 | IFT122 | RPL32P3 | D/R | 0.10 | 0.009 | 1.0 × 10−08 | |
| 7p14.2 | rs2710804 | 36 084 529 | EEPD1 | C/T | 0.37 | 0.0055 | 2.9 × 10−09 | ||
| 7q36.1 | 7:150289652 | 150 289 652 | GIMAP4 | GIMAP4 | D/R | 0.21 | −0.0073 | 9.3 × 10−11 | |
| 8p23.1 | rs7012814 | 9 173 358 | LOC157273 | A/G | 0.47 | 0.0060 | 2.1 × 10−10 | ||
| 9q22.2 | rs3138493 | 92 219 260 | GADD45G | SEMA4D | T/C | 0.48 | −0.0054 | 2.5 × 10−09 | |
| 10q23.31 | rs2250644 | 91 008 879 | LIPA | T/C | 0.33 | 0.0054 | 2.2 × 10−08 | ||
| 10q26.13 | rs2420915 | 122 840 277 | MIR5694 | WDR11 | A/G | 0.09 | −0.0094 | 5.2 × 10−09 | |
| 11p12 | rs7934094 | 43 505 707 | TTC17 | G/T | 0.22 | −0.0083 | 2.5 × 10−13 | ||
| 12p12.1 | 12:21703935 | 21 703 935 | GYS2 | R/D | 0.37 | 0.0062 | 8.4 × 10−09 | ||
| 12q24.12 | rs7310615 | 111 865 049 | SH2B3 | SH2B3 | SH2B3 | C/G | 0.50 | −0.0069 | 1.5 × 10−13 |
| 15q15.1 | rs56702977 | 42 671 308 | CAPN3 | ZFP106 | A/G | 0.13 | 0.0080 | 2.1 × 10−09 | |
| 16p11.2 | 16:28845027 | 28 845 027 | ATXN2L | TUFM | D/R | 0.39 | 0.0061 | 7.7 × 10−10 | |
| 16q22.2 | rs1035560 | 72 032 730 | PKD1L3 | HP | C/T | 0.40 | 0.0064 | 2.6 × 10−12 | |
| 17q21.2 | rs7224737 | 40 289 364 | RAB5C | STAT3 | HSPB9 | A/G | 0.24 | 0.0061 | 6.1 × 10−09 |
| 19q13.33 | rs73058052 | 50 099 422 | PRR12 | IRF3 | PRRG2 | T/C | 0.16 | 0.0074 | 2.0 × 10−08 |
| Locus . | Variant . | Position . | Closest gene . | eQTL . | NSYN variants . | A1/A2 . | Frequency . | β . | P-values . |
|---|---|---|---|---|---|---|---|---|---|
| 2p25.3 | rs7588285 | 3 648 186 | COLEC11 | C/G | 0.20 | 0.0074 | 1.2 × 10−08 | ||
| 3p25.3 | rs62246343 | 9 543 642 | LHFPL4 | T/C | 0.17 | 0.0071 | 2.2 × 10−08 | ||
| 3q21.1 | rs1976714 | 122 864 771 | PDIA5 | T/G | 0.35 | −0.0055 | 2.3 × 10−08 | ||
| 3q21.3 | 3:129228166 | 129 228 166 | IFT122 | RPL32P3 | D/R | 0.10 | 0.009 | 1.0 × 10−08 | |
| 7p14.2 | rs2710804 | 36 084 529 | EEPD1 | C/T | 0.37 | 0.0055 | 2.9 × 10−09 | ||
| 7q36.1 | 7:150289652 | 150 289 652 | GIMAP4 | GIMAP4 | D/R | 0.21 | −0.0073 | 9.3 × 10−11 | |
| 8p23.1 | rs7012814 | 9 173 358 | LOC157273 | A/G | 0.47 | 0.0060 | 2.1 × 10−10 | ||
| 9q22.2 | rs3138493 | 92 219 260 | GADD45G | SEMA4D | T/C | 0.48 | −0.0054 | 2.5 × 10−09 | |
| 10q23.31 | rs2250644 | 91 008 879 | LIPA | T/C | 0.33 | 0.0054 | 2.2 × 10−08 | ||
| 10q26.13 | rs2420915 | 122 840 277 | MIR5694 | WDR11 | A/G | 0.09 | −0.0094 | 5.2 × 10−09 | |
| 11p12 | rs7934094 | 43 505 707 | TTC17 | G/T | 0.22 | −0.0083 | 2.5 × 10−13 | ||
| 12p12.1 | 12:21703935 | 21 703 935 | GYS2 | R/D | 0.37 | 0.0062 | 8.4 × 10−09 | ||
| 12q24.12 | rs7310615 | 111 865 049 | SH2B3 | SH2B3 | SH2B3 | C/G | 0.50 | −0.0069 | 1.5 × 10−13 |
| 15q15.1 | rs56702977 | 42 671 308 | CAPN3 | ZFP106 | A/G | 0.13 | 0.0080 | 2.1 × 10−09 | |
| 16p11.2 | 16:28845027 | 28 845 027 | ATXN2L | TUFM | D/R | 0.39 | 0.0061 | 7.7 × 10−10 | |
| 16q22.2 | rs1035560 | 72 032 730 | PKD1L3 | HP | C/T | 0.40 | 0.0064 | 2.6 × 10−12 | |
| 17q21.2 | rs7224737 | 40 289 364 | RAB5C | STAT3 | HSPB9 | A/G | 0.24 | 0.0061 | 6.1 × 10−09 |
| 19q13.33 | rs73058052 | 50 099 422 | PRR12 | IRF3 | PRRG2 | T/C | 0.16 | 0.0074 | 2.0 × 10−08 |
eQTL indicates the gene with the strongest significant association between its expression levels in blood and the lead variant or its proxy. NSYN variants indicates genes containing non-synonymous variant correlated to the lead variant (R2 > 0.9). A1 indicates the coded allele. A2 indicates the other allele. Frequency is the frequency of the coded allele. β indicates the β-coefficient adjusted for age, sex, population structure and study-specific covariates, such as center or case/control status. The β-coefficient can be interpreted as the ln(g/l) change in fibrinogen per 1 unit change in the dosage of the coded allele.
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