Table 3
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Effects of ranolazine on G protein-coupled receptors (GPCR)

GPCRPreparationPotency (Ki, μM)CommentsReferences
α1Rat salivary gland8.2Radioligand bindingZhao et al.62
Rat liver19.5
Rat ventricle10.5
β1Rat ventricle8.6BindingZhao et al.62
Rat heart1.4Letienne et al.63
β2Guinea pig lung14.8BindingZhao et al.62
Guinea pig lung0.5BindingLetienne et al.63
DDT1MF-2 cells9.0BindingGilead, unpublished data
GPCRPreparationPotency (Ki, μM)CommentsReferences
α1Rat salivary gland8.2Radioligand bindingZhao et al.62
Rat liver19.5
Rat ventricle10.5
β1Rat ventricle8.6BindingZhao et al.62
Rat heart1.4Letienne et al.63
β2Guinea pig lung14.8BindingZhao et al.62
Guinea pig lung0.5BindingLetienne et al.63
DDT1MF-2 cells9.0BindingGilead, unpublished data
Table 3
Open in new tab

Effects of ranolazine on G protein-coupled receptors (GPCR)

GPCRPreparationPotency (Ki, μM)CommentsReferences
α1Rat salivary gland8.2Radioligand bindingZhao et al.62
Rat liver19.5
Rat ventricle10.5
β1Rat ventricle8.6BindingZhao et al.62
Rat heart1.4Letienne et al.63
β2Guinea pig lung14.8BindingZhao et al.62
Guinea pig lung0.5BindingLetienne et al.63
DDT1MF-2 cells9.0BindingGilead, unpublished data
GPCRPreparationPotency (Ki, μM)CommentsReferences
α1Rat salivary gland8.2Radioligand bindingZhao et al.62
Rat liver19.5
Rat ventricle10.5
β1Rat ventricle8.6BindingZhao et al.62
Rat heart1.4Letienne et al.63
β2Guinea pig lung14.8BindingZhao et al.62
Guinea pig lung0.5BindingLetienne et al.63
DDT1MF-2 cells9.0BindingGilead, unpublished data
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