The main descriptive statistics of the entire study population contained in the data banks of the two statutory medical insurance funds as well as of our atrial fibrillation sample (atrial fibrillation prevalence cases)
| Variable . | AF patients . | Whole sample . | ||
|---|---|---|---|---|
| N | 176 891 | 8 298 896 | ||
| Ø Age in yearsa | 73.14 | (SD: 10.91) | 43.48 | |
| Gender | ||||
| Female | 78 701 | (44.5%) | 4 153 882 | (50.1%) |
| Male | 98 190 | (55.5%) | 4 145 014 | (49.9%) |
| Ø Total number of different drugs prescribed (2007/2008) | 15.27 | (SD: 10.63) | ||
| Ø CHADS2 score | 2.79 | (SD: 1.56) | ||
| Ø CHA2DS2-VASc score | 4.24 | (SD: 2.02) | ||
| Observed clinical events (primary diagnosis leading to hospital admission in 2008); number of patients | ||||
| Stroke | 2798 | (1.6%) | ||
| Transient ischemic attack | 1233 | (0.7%) | ||
| Embolism | 427 | (0.2%) | ||
| Myocardial infarct | 1598 | (0.9%) | ||
| Severe gastrointestinal, pulmonary, urinary bleeding, haemorrhagic diathesis | 763 | (0.4%) | ||
| Ø Charlson comorbidity indexb | 4.23 | (SD: 3.10) | ||
| Comorbidities | ||||
| Hypertension | 154 560 | (87.4%) | ||
| Heart failure | 74 515 | (42.1%) | ||
| Vascular diseasec | 36 041 | (20.4%) | ||
| Diabetes mellitus | 76 604 | (43.3%) | ||
| Asthma/COPD | 59 833 | (33.8%) | ||
| Rheumatism | 8274 | (4.7%) | ||
| Avg. number of hospitalizations per year with AF-diagnosis (ICD10-Code I48.1-)d | 0.24 | (SD: 0.64) | ||
| Avg. number of outpatient consultations per year with AF-diagnosis (ICD10-Code I48.1-)e | 5.62 | (SD: 3.75) | ||
| Most frequently prescribed medications (at least two prescriptions in 2007/2008) | ||||
| Phenprocoumon (ATC-code B01AA04) | 91 474 | (51.7%) | ||
| Metoprolol (ATC-code C07AB02) | 68 441 | (38.7%) | ||
| Torasemid (ATC-code C03CA04) | 55 906 | (31.6%) | ||
| Bisoprolol (ATC-code C07AB07) | 54 100 | (30.6%) | ||
| Simvastatin (ATC-code C10AA01) | 53 928 | (30.5%) | ||
| Prescribed antiarrhythmic agents (at least two prescriptions in 2007/2008) | ||||
| Class I (ATC-code C01BA-/C01BB-/C01BC-) | 10 155 | (5.7%) | ||
| Class II (ATC-code C07AB-/C07AG-) | 131 654 | (74.4%) | ||
| Class III (ATC-code C01BD-) | 10 434 | (5.9%) | ||
| Class IV (ATC-code C08-) | 63 058 | (35.6%) | ||
| Without any prescription for antiarrhythmic agents in 2007/2008 | 24 499 | (13.8%) | ||
| Variable . | AF patients . | Whole sample . | ||
|---|---|---|---|---|
| N | 176 891 | 8 298 896 | ||
| Ø Age in yearsa | 73.14 | (SD: 10.91) | 43.48 | |
| Gender | ||||
| Female | 78 701 | (44.5%) | 4 153 882 | (50.1%) |
| Male | 98 190 | (55.5%) | 4 145 014 | (49.9%) |
| Ø Total number of different drugs prescribed (2007/2008) | 15.27 | (SD: 10.63) | ||
| Ø CHADS2 score | 2.79 | (SD: 1.56) | ||
| Ø CHA2DS2-VASc score | 4.24 | (SD: 2.02) | ||
| Observed clinical events (primary diagnosis leading to hospital admission in 2008); number of patients | ||||
| Stroke | 2798 | (1.6%) | ||
| Transient ischemic attack | 1233 | (0.7%) | ||
| Embolism | 427 | (0.2%) | ||
| Myocardial infarct | 1598 | (0.9%) | ||
| Severe gastrointestinal, pulmonary, urinary bleeding, haemorrhagic diathesis | 763 | (0.4%) | ||
| Ø Charlson comorbidity indexb | 4.23 | (SD: 3.10) | ||
| Comorbidities | ||||
| Hypertension | 154 560 | (87.4%) | ||
| Heart failure | 74 515 | (42.1%) | ||
| Vascular diseasec | 36 041 | (20.4%) | ||
| Diabetes mellitus | 76 604 | (43.3%) | ||
| Asthma/COPD | 59 833 | (33.8%) | ||
| Rheumatism | 8274 | (4.7%) | ||
| Avg. number of hospitalizations per year with AF-diagnosis (ICD10-Code I48.1-)d | 0.24 | (SD: 0.64) | ||
| Avg. number of outpatient consultations per year with AF-diagnosis (ICD10-Code I48.1-)e | 5.62 | (SD: 3.75) | ||
| Most frequently prescribed medications (at least two prescriptions in 2007/2008) | ||||
| Phenprocoumon (ATC-code B01AA04) | 91 474 | (51.7%) | ||
| Metoprolol (ATC-code C07AB02) | 68 441 | (38.7%) | ||
| Torasemid (ATC-code C03CA04) | 55 906 | (31.6%) | ||
| Bisoprolol (ATC-code C07AB07) | 54 100 | (30.6%) | ||
| Simvastatin (ATC-code C10AA01) | 53 928 | (30.5%) | ||
| Prescribed antiarrhythmic agents (at least two prescriptions in 2007/2008) | ||||
| Class I (ATC-code C01BA-/C01BB-/C01BC-) | 10 155 | (5.7%) | ||
| Class II (ATC-code C07AB-/C07AG-) | 131 654 | (74.4%) | ||
| Class III (ATC-code C01BD-) | 10 434 | (5.9%) | ||
| Class IV (ATC-code C08-) | 63 058 | (35.6%) | ||
| Without any prescription for antiarrhythmic agents in 2007/2008 | 24 499 | (13.8%) | ||
aBased on 31 December 2008; Whole sample: average of each age class.
bScore value 1: coronary artery disease (61.4%), congestive heart failure (43.8%), peripheral vascular disease (13.9%), cerebral vascular accident (33.2%), dementia (13.1%), pulmonary disease (34.8%), connective tissue disorder (10.7%), peptic ulcer (6.9%), mild liver disease (1.6%), diabetes without complications (21.4%); score value 2: diabetes with complications (21.9%); paraplegia (6.3%); renal disease (23.4%); any tumour/leukaemia/lymphoma (22.9%); score value 3: moderate or severe liver disease (1.8%); score value 6: metastatic cancer (3.5%); AIDS (0.3%); age factor: 1 additional point for each decade ≥50 years of age.
cPrior myocardial infarct/peripheral artery disease/aortic plaque.
dReference year 2008.
eReference year 2008; all outpatient consultations with specialist and family physicians.
COPD, chronic obstructive pulmonary disease.
The main descriptive statistics of the entire study population contained in the data banks of the two statutory medical insurance funds as well as of our atrial fibrillation sample (atrial fibrillation prevalence cases)
| Variable . | AF patients . | Whole sample . | ||
|---|---|---|---|---|
| N | 176 891 | 8 298 896 | ||
| Ø Age in yearsa | 73.14 | (SD: 10.91) | 43.48 | |
| Gender | ||||
| Female | 78 701 | (44.5%) | 4 153 882 | (50.1%) |
| Male | 98 190 | (55.5%) | 4 145 014 | (49.9%) |
| Ø Total number of different drugs prescribed (2007/2008) | 15.27 | (SD: 10.63) | ||
| Ø CHADS2 score | 2.79 | (SD: 1.56) | ||
| Ø CHA2DS2-VASc score | 4.24 | (SD: 2.02) | ||
| Observed clinical events (primary diagnosis leading to hospital admission in 2008); number of patients | ||||
| Stroke | 2798 | (1.6%) | ||
| Transient ischemic attack | 1233 | (0.7%) | ||
| Embolism | 427 | (0.2%) | ||
| Myocardial infarct | 1598 | (0.9%) | ||
| Severe gastrointestinal, pulmonary, urinary bleeding, haemorrhagic diathesis | 763 | (0.4%) | ||
| Ø Charlson comorbidity indexb | 4.23 | (SD: 3.10) | ||
| Comorbidities | ||||
| Hypertension | 154 560 | (87.4%) | ||
| Heart failure | 74 515 | (42.1%) | ||
| Vascular diseasec | 36 041 | (20.4%) | ||
| Diabetes mellitus | 76 604 | (43.3%) | ||
| Asthma/COPD | 59 833 | (33.8%) | ||
| Rheumatism | 8274 | (4.7%) | ||
| Avg. number of hospitalizations per year with AF-diagnosis (ICD10-Code I48.1-)d | 0.24 | (SD: 0.64) | ||
| Avg. number of outpatient consultations per year with AF-diagnosis (ICD10-Code I48.1-)e | 5.62 | (SD: 3.75) | ||
| Most frequently prescribed medications (at least two prescriptions in 2007/2008) | ||||
| Phenprocoumon (ATC-code B01AA04) | 91 474 | (51.7%) | ||
| Metoprolol (ATC-code C07AB02) | 68 441 | (38.7%) | ||
| Torasemid (ATC-code C03CA04) | 55 906 | (31.6%) | ||
| Bisoprolol (ATC-code C07AB07) | 54 100 | (30.6%) | ||
| Simvastatin (ATC-code C10AA01) | 53 928 | (30.5%) | ||
| Prescribed antiarrhythmic agents (at least two prescriptions in 2007/2008) | ||||
| Class I (ATC-code C01BA-/C01BB-/C01BC-) | 10 155 | (5.7%) | ||
| Class II (ATC-code C07AB-/C07AG-) | 131 654 | (74.4%) | ||
| Class III (ATC-code C01BD-) | 10 434 | (5.9%) | ||
| Class IV (ATC-code C08-) | 63 058 | (35.6%) | ||
| Without any prescription for antiarrhythmic agents in 2007/2008 | 24 499 | (13.8%) | ||
| Variable . | AF patients . | Whole sample . | ||
|---|---|---|---|---|
| N | 176 891 | 8 298 896 | ||
| Ø Age in yearsa | 73.14 | (SD: 10.91) | 43.48 | |
| Gender | ||||
| Female | 78 701 | (44.5%) | 4 153 882 | (50.1%) |
| Male | 98 190 | (55.5%) | 4 145 014 | (49.9%) |
| Ø Total number of different drugs prescribed (2007/2008) | 15.27 | (SD: 10.63) | ||
| Ø CHADS2 score | 2.79 | (SD: 1.56) | ||
| Ø CHA2DS2-VASc score | 4.24 | (SD: 2.02) | ||
| Observed clinical events (primary diagnosis leading to hospital admission in 2008); number of patients | ||||
| Stroke | 2798 | (1.6%) | ||
| Transient ischemic attack | 1233 | (0.7%) | ||
| Embolism | 427 | (0.2%) | ||
| Myocardial infarct | 1598 | (0.9%) | ||
| Severe gastrointestinal, pulmonary, urinary bleeding, haemorrhagic diathesis | 763 | (0.4%) | ||
| Ø Charlson comorbidity indexb | 4.23 | (SD: 3.10) | ||
| Comorbidities | ||||
| Hypertension | 154 560 | (87.4%) | ||
| Heart failure | 74 515 | (42.1%) | ||
| Vascular diseasec | 36 041 | (20.4%) | ||
| Diabetes mellitus | 76 604 | (43.3%) | ||
| Asthma/COPD | 59 833 | (33.8%) | ||
| Rheumatism | 8274 | (4.7%) | ||
| Avg. number of hospitalizations per year with AF-diagnosis (ICD10-Code I48.1-)d | 0.24 | (SD: 0.64) | ||
| Avg. number of outpatient consultations per year with AF-diagnosis (ICD10-Code I48.1-)e | 5.62 | (SD: 3.75) | ||
| Most frequently prescribed medications (at least two prescriptions in 2007/2008) | ||||
| Phenprocoumon (ATC-code B01AA04) | 91 474 | (51.7%) | ||
| Metoprolol (ATC-code C07AB02) | 68 441 | (38.7%) | ||
| Torasemid (ATC-code C03CA04) | 55 906 | (31.6%) | ||
| Bisoprolol (ATC-code C07AB07) | 54 100 | (30.6%) | ||
| Simvastatin (ATC-code C10AA01) | 53 928 | (30.5%) | ||
| Prescribed antiarrhythmic agents (at least two prescriptions in 2007/2008) | ||||
| Class I (ATC-code C01BA-/C01BB-/C01BC-) | 10 155 | (5.7%) | ||
| Class II (ATC-code C07AB-/C07AG-) | 131 654 | (74.4%) | ||
| Class III (ATC-code C01BD-) | 10 434 | (5.9%) | ||
| Class IV (ATC-code C08-) | 63 058 | (35.6%) | ||
| Without any prescription for antiarrhythmic agents in 2007/2008 | 24 499 | (13.8%) | ||
aBased on 31 December 2008; Whole sample: average of each age class.
bScore value 1: coronary artery disease (61.4%), congestive heart failure (43.8%), peripheral vascular disease (13.9%), cerebral vascular accident (33.2%), dementia (13.1%), pulmonary disease (34.8%), connective tissue disorder (10.7%), peptic ulcer (6.9%), mild liver disease (1.6%), diabetes without complications (21.4%); score value 2: diabetes with complications (21.9%); paraplegia (6.3%); renal disease (23.4%); any tumour/leukaemia/lymphoma (22.9%); score value 3: moderate or severe liver disease (1.8%); score value 6: metastatic cancer (3.5%); AIDS (0.3%); age factor: 1 additional point for each decade ≥50 years of age.
cPrior myocardial infarct/peripheral artery disease/aortic plaque.
dReference year 2008.
eReference year 2008; all outpatient consultations with specialist and family physicians.
COPD, chronic obstructive pulmonary disease.
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