Table 2: Open in new tab Haemodynamic...

	No response (n = 18)	Response (n = 14)	P
HR (b min⁻¹)
T₀	75 [21]	82 [12]	0.23
T₁	74 [20]	80 [13]	0.57
T₂	73 [19]	77 [47]	0.80
T₂–T₀	−1 [5]	−4 [4]	<0.001
SAP (mmHg)
T₀	112 [18]	91 [10]	<0.001
T₁	117 [29]	107 [23]	0.16
T₂	127 [29]	111 [19]	0.091
T₂–T₀	16 [31]	19 [18]	0.25
MAP (mmHg)
T₀	74 [14]	63 [8]	0.001
T₁	76 [15]	72 [11]	0.19
T₂	82 [13]	75 [9]	0.091
T₂–T₀	9 [20]	11 [12]	0.32
CVP (cmH₂O)
T₀	6 [3]	6 [5]	0.46
T₁	6 [3]	7 [4]	0.38
T₂	6 [2]	7 [4]	0.60
T₂–T₀	1 [2]	0 [2]	0.45
PAOP (mmHg)
T₀	8 [6]	9 [7]	0.89
T₁	11 [6]	10 [3]	0.35
T₂	10 [5]	9 [4]	0.55
T₂–T₀	1 [5]	2 [4]	0.77
CO (ml min⁻¹)
T₀	5.4 [2.3]	4.8 [2.4]	0.17
T₁	5.3 [2.0]	5.3 [1.9]	0.88
T₂	5.2 [2.1]	5.6 [2.8]	0.62
T₂–T₀	−0.3 [0.42]	0.9 [0.6]	<0.001
SV (ml)
T₀	71.2 [34.3]	58.7 [25.8]	0.04
T₁	69.3 [24.9]	66.9 [35.5]	0.91
T₂	63.9 [28.0]	73.5 [44.1]	0.54
T₂–T₀	−4.7 [8.1]	13.3 [8.5]	<0.001
S_vO₂
T₀	0.76 [0.09]	0.71 [0.09]	0.34
T₁	0.72 [0.12]	0.71 [0.11]	0.66
T₂	0.68 [0.09]	0.72 [0.06]	0.04
T₂–T₀	−0.03 [0.08]	0.01 [0.06]	0.014
PEP (ms)
T₀	185 [14]	198 [25]	0.08
T₁	182 [19]	189 [18]	0.21
T₂	174 [22]	186 [26]	0.068
T₂–T₀	−8 [16]	−4 [23]	0.73
dPEP (%)
T₀	12.8 [6.2]	15.0 [7.4]	0.29
T₁	7.2 [2.9]	8.7 [4.6]	0.29
T₂	7.0 [4.8]	7.9 [3.6]	0.97
T₂–T₀	−5.6 [7.2]	−6.5 [5.7]	0.38
ISTI (ms)
T₀	145 [24]	158 [25]	0.04
T₁	147 [29]	153 [36]	0.49
T₂	147 [29]	152 [34]	0.60
T₂–T₀	5 [13]	−7 [17]	0.012
dISTI (%)
T₀	22.4 [17.8]	21.2 [27.4]	0.70
T₁	15.2 [13.1]	15.2 [6.5]	0.82
T₂	17.4 [7.4]	15.6 [10.9]	0.79
T₂–T₀	−5.4 [10.5]	−4.7 [20.6]	0.91

No response (n = 18)

Response (n = 14)

HR (b min⁻¹)

T₀

75 [21]

82 [12]

0.23

T₁

74 [20]

80 [13]

0.57

T₂

73 [19]

77 [47]

0.80

T₂–T₀

−1 [5]

−4 [4]

<0.001

SAP (mmHg)

T₀

112 [18]

91 [10]

<0.001

T₁

117 [29]

107 [23]

0.16

T₂

127 [29]

111 [19]

0.091

T₂–T₀

16 [31]

19 [18]

0.25

MAP (mmHg)

T₀

74 [14]

63 [8]

0.001

T₁

76 [15]

72 [11]

0.19

T₂

82 [13]

75 [9]

0.091

T₂–T₀

9 [20]

11 [12]

0.32

CVP (cmH₂O)

T₀

6 [3]

6 [5]

0.46

T₁

6 [3]

7 [4]

0.38

T₂

6 [2]

7 [4]

0.60

T₂–T₀

1 [2]

0 [2]

0.45

PAOP (mmHg)

T₀

8 [6]

9 [7]

0.89

T₁

11 [6]

10 [3]

0.35

T₂

10 [5]

9 [4]

0.55

T₂–T₀

1 [5]

2 [4]

0.77

CO (ml min⁻¹)

T₀

5.4 [2.3]

4.8 [2.4]

0.17

T₁

5.3 [2.0]

5.3 [1.9]

0.88

T₂

5.2 [2.1]

5.6 [2.8]

0.62

T₂–T₀

−0.3 [0.42]

0.9 [0.6]

<0.001

SV (ml)

T₀

71.2 [34.3]

58.7 [25.8]

0.04

T₁

69.3 [24.9]

66.9 [35.5]

0.91

T₂

63.9 [28.0]

73.5 [44.1]

0.54

T₂–T₀

−4.7 [8.1]

13.3 [8.5]

<0.001

S_vO₂

T₀

0.76 [0.09]

0.71 [0.09]

0.34

T₁

0.72 [0.12]

0.71 [0.11]

0.66

T₂

0.68 [0.09]

0.72 [0.06]

0.04

T₂–T₀

−0.03 [0.08]

0.01 [0.06]

0.014

PEP (ms)

T₀

185 [14]

198 [25]

0.08

T₁

182 [19]

189 [18]

0.21

T₂

174 [22]

186 [26]

0.068

T₂–T₀

−8 [16]

−4 [23]

0.73

dPEP (%)

T₀

12.8 [6.2]

15.0 [7.4]

0.29

T₁

7.2 [2.9]

8.7 [4.6]

0.29

T₂

7.0 [4.8]

7.9 [3.6]

0.97

T₂–T₀

−5.6 [7.2]

−6.5 [5.7]

0.38

ISTI (ms)

T₀

145 [24]

158 [25]

0.04

T₁

147 [29]

153 [36]

0.49

T₂

147 [29]

152 [34]

0.60

T₂–T₀

5 [13]

−7 [17]

0.012

dISTI (%)

T₀

22.4 [17.8]

21.2 [27.4]

0.70

T₁

15.2 [13.1]

15.2 [6.5]

0.82

T₂

17.4 [7.4]

15.6 [10.9]

0.79

T₂–T₀

−5.4 [10.5]

−4.7 [20.6]

0.91

	No response (n = 18)	Response (n = 14)	P
HR (b min⁻¹)
T₀	75 [21]	82 [12]	0.23
T₁	74 [20]	80 [13]	0.57
T₂	73 [19]	77 [47]	0.80
T₂–T₀	−1 [5]	−4 [4]	<0.001
SAP (mmHg)
T₀	112 [18]	91 [10]	<0.001
T₁	117 [29]	107 [23]	0.16
T₂	127 [29]	111 [19]	0.091
T₂–T₀	16 [31]	19 [18]	0.25
MAP (mmHg)
T₀	74 [14]	63 [8]	0.001
T₁	76 [15]	72 [11]	0.19
T₂	82 [13]	75 [9]	0.091
T₂–T₀	9 [20]	11 [12]	0.32
CVP (cmH₂O)
T₀	6 [3]	6 [5]	0.46
T₁	6 [3]	7 [4]	0.38
T₂	6 [2]	7 [4]	0.60
T₂–T₀	1 [2]	0 [2]	0.45
PAOP (mmHg)
T₀	8 [6]	9 [7]	0.89
T₁	11 [6]	10 [3]	0.35
T₂	10 [5]	9 [4]	0.55
T₂–T₀	1 [5]	2 [4]	0.77
CO (ml min⁻¹)
T₀	5.4 [2.3]	4.8 [2.4]	0.17
T₁	5.3 [2.0]	5.3 [1.9]	0.88
T₂	5.2 [2.1]	5.6 [2.8]	0.62
T₂–T₀	−0.3 [0.42]	0.9 [0.6]	<0.001
SV (ml)
T₀	71.2 [34.3]	58.7 [25.8]	0.04
T₁	69.3 [24.9]	66.9 [35.5]	0.91
T₂	63.9 [28.0]	73.5 [44.1]	0.54
T₂–T₀	−4.7 [8.1]	13.3 [8.5]	<0.001
S_vO₂
T₀	0.76 [0.09]	0.71 [0.09]	0.34
T₁	0.72 [0.12]	0.71 [0.11]	0.66
T₂	0.68 [0.09]	0.72 [0.06]	0.04
T₂–T₀	−0.03 [0.08]	0.01 [0.06]	0.014
PEP (ms)
T₀	185 [14]	198 [25]	0.08
T₁	182 [19]	189 [18]	0.21
T₂	174 [22]	186 [26]	0.068
T₂–T₀	−8 [16]	−4 [23]	0.73
dPEP (%)
T₀	12.8 [6.2]	15.0 [7.4]	0.29
T₁	7.2 [2.9]	8.7 [4.6]	0.29
T₂	7.0 [4.8]	7.9 [3.6]	0.97
T₂–T₀	−5.6 [7.2]	−6.5 [5.7]	0.38
ISTI (ms)
T₀	145 [24]	158 [25]	0.04
T₁	147 [29]	153 [36]	0.49
T₂	147 [29]	152 [34]	0.60
T₂–T₀	5 [13]	−7 [17]	0.012
dISTI (%)
T₀	22.4 [17.8]	21.2 [27.4]	0.70
T₁	15.2 [13.1]	15.2 [6.5]	0.82
T₂	17.4 [7.4]	15.6 [10.9]	0.79
T₂–T₀	−5.4 [10.5]	−4.7 [20.6]	0.91

Table 2:

Open in new tab

Haemodynamic parameters

	No response (n = 18)	Response (n = 14)	P
HR (b min⁻¹)
T₀	75 [21]	82 [12]	0.23
T₁	74 [20]	80 [13]	0.57
T₂	73 [19]	77 [47]	0.80
T₂–T₀	−1 [5]	−4 [4]	<0.001
SAP (mmHg)
T₀	112 [18]	91 [10]	<0.001
T₁	117 [29]	107 [23]	0.16
T₂	127 [29]	111 [19]	0.091
T₂–T₀	16 [31]	19 [18]	0.25
MAP (mmHg)
T₀	74 [14]	63 [8]	0.001
T₁	76 [15]	72 [11]	0.19
T₂	82 [13]	75 [9]	0.091
T₂–T₀	9 [20]	11 [12]	0.32
CVP (cmH₂O)
T₀	6 [3]	6 [5]	0.46
T₁	6 [3]	7 [4]	0.38
T₂	6 [2]	7 [4]	0.60
T₂–T₀	1 [2]	0 [2]	0.45
PAOP (mmHg)
T₀	8 [6]	9 [7]	0.89
T₁	11 [6]	10 [3]	0.35
T₂	10 [5]	9 [4]	0.55
T₂–T₀	1 [5]	2 [4]	0.77
CO (ml min⁻¹)
T₀	5.4 [2.3]	4.8 [2.4]	0.17
T₁	5.3 [2.0]	5.3 [1.9]	0.88
T₂	5.2 [2.1]	5.6 [2.8]	0.62
T₂–T₀	−0.3 [0.42]	0.9 [0.6]	<0.001
SV (ml)
T₀	71.2 [34.3]	58.7 [25.8]	0.04
T₁	69.3 [24.9]	66.9 [35.5]	0.91
T₂	63.9 [28.0]	73.5 [44.1]	0.54
T₂–T₀	−4.7 [8.1]	13.3 [8.5]	<0.001
S_vO₂
T₀	0.76 [0.09]	0.71 [0.09]	0.34
T₁	0.72 [0.12]	0.71 [0.11]	0.66
T₂	0.68 [0.09]	0.72 [0.06]	0.04
T₂–T₀	−0.03 [0.08]	0.01 [0.06]	0.014
PEP (ms)
T₀	185 [14]	198 [25]	0.08
T₁	182 [19]	189 [18]	0.21
T₂	174 [22]	186 [26]	0.068
T₂–T₀	−8 [16]	−4 [23]	0.73
dPEP (%)
T₀	12.8 [6.2]	15.0 [7.4]	0.29
T₁	7.2 [2.9]	8.7 [4.6]	0.29
T₂	7.0 [4.8]	7.9 [3.6]	0.97
T₂–T₀	−5.6 [7.2]	−6.5 [5.7]	0.38
ISTI (ms)
T₀	145 [24]	158 [25]	0.04
T₁	147 [29]	153 [36]	0.49
T₂	147 [29]	152 [34]	0.60
T₂–T₀	5 [13]	−7 [17]	0.012
dISTI (%)
T₀	22.4 [17.8]	21.2 [27.4]	0.70
T₁	15.2 [13.1]	15.2 [6.5]	0.82
T₂	17.4 [7.4]	15.6 [10.9]	0.79
T₂–T₀	−5.4 [10.5]	−4.7 [20.6]	0.91

	No response (n = 18)	Response (n = 14)	P
HR (b min⁻¹)
T₀	75 [21]	82 [12]	0.23
T₁	74 [20]	80 [13]	0.57
T₂	73 [19]	77 [47]	0.80
T₂–T₀	−1 [5]	−4 [4]	<0.001
SAP (mmHg)
T₀	112 [18]	91 [10]	<0.001
T₁	117 [29]	107 [23]	0.16
T₂	127 [29]	111 [19]	0.091
T₂–T₀	16 [31]	19 [18]	0.25
MAP (mmHg)
T₀	74 [14]	63 [8]	0.001
T₁	76 [15]	72 [11]	0.19
T₂	82 [13]	75 [9]	0.091
T₂–T₀	9 [20]	11 [12]	0.32
CVP (cmH₂O)
T₀	6 [3]	6 [5]	0.46
T₁	6 [3]	7 [4]	0.38
T₂	6 [2]	7 [4]	0.60
T₂–T₀	1 [2]	0 [2]	0.45
PAOP (mmHg)
T₀	8 [6]	9 [7]	0.89
T₁	11 [6]	10 [3]	0.35
T₂	10 [5]	9 [4]	0.55
T₂–T₀	1 [5]	2 [4]	0.77
CO (ml min⁻¹)
T₀	5.4 [2.3]	4.8 [2.4]	0.17
T₁	5.3 [2.0]	5.3 [1.9]	0.88
T₂	5.2 [2.1]	5.6 [2.8]	0.62
T₂–T₀	−0.3 [0.42]	0.9 [0.6]	<0.001
SV (ml)
T₀	71.2 [34.3]	58.7 [25.8]	0.04
T₁	69.3 [24.9]	66.9 [35.5]	0.91
T₂	63.9 [28.0]	73.5 [44.1]	0.54
T₂–T₀	−4.7 [8.1]	13.3 [8.5]	<0.001
S_vO₂
T₀	0.76 [0.09]	0.71 [0.09]	0.34
T₁	0.72 [0.12]	0.71 [0.11]	0.66
T₂	0.68 [0.09]	0.72 [0.06]	0.04
T₂–T₀	−0.03 [0.08]	0.01 [0.06]	0.014
PEP (ms)
T₀	185 [14]	198 [25]	0.08
T₁	182 [19]	189 [18]	0.21
T₂	174 [22]	186 [26]	0.068
T₂–T₀	−8 [16]	−4 [23]	0.73
dPEP (%)
T₀	12.8 [6.2]	15.0 [7.4]	0.29
T₁	7.2 [2.9]	8.7 [4.6]	0.29
T₂	7.0 [4.8]	7.9 [3.6]	0.97
T₂–T₀	−5.6 [7.2]	−6.5 [5.7]	0.38
ISTI (ms)
T₀	145 [24]	158 [25]	0.04
T₁	147 [29]	153 [36]	0.49
T₂	147 [29]	152 [34]	0.60
T₂–T₀	5 [13]	−7 [17]	0.012
dISTI (%)
T₀	22.4 [17.8]	21.2 [27.4]	0.70
T₁	15.2 [13.1]	15.2 [6.5]	0.82
T₂	17.4 [7.4]	15.6 [10.9]	0.79
T₂–T₀	−5.4 [10.5]	−4.7 [20.6]	0.91

Values are median [interquartile range]. HR: heart rate; SAP: systolic arterial pressure; MAP: mean arterial pressure; CVP: central venous pressure; PAOP: pulmonary artery occlusion pressure; CO: cardiac output; SV: stroke volume; S_vO₂: mixed venous O₂ saturation; PEP: mean pre-ejection period; dPEP: respiratory variation in PEP; ISTI: mean initial systolic time interval; dISTI: respiratory variation in ISTI; T₀: baseline measurement; T₁: after the first volume loading step (VLS) of 250 ml Gelofusin^®; T₂: after the second VLS.

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