| . | Non-diabetic (n = 1348) . | Diabetic (n = 452) . | P-value . |
|---|---|---|---|
| Age (years) | 65.0 ± 9.9 (1348) | 65.4 ± 9.2 | 0.049 |
| Male gender | 79.9 (1077/1348) | 71.0 (321/452) | <0.001 |
| Comorbid risk factors | |||
| Body mass index (kg/m2) | 27.5 ± 4.4 | 29.5 ± 5.2 | <0.001 |
| Metabolic syndromea | 37% (398/1064) | 70% (258/369) | <0.001 |
| Waist >40 in. for male, >35 in. for female | 42% (502/1194) | 61% (238/393) | <0.001 |
| Triglycerides ≥150 mg/dlb | 33% (409/1230) | 42% (170/408) | 0.002 |
| HDL <40 mg/dl male, <50 mg/dl femaleb | 45% (544/1199) | 61% (238/389) | <0.001 |
| Blood pressure ≥130/85 mmHg | 65% (80/1348) | 70% (316/452) | 0.071 |
| Fasting glucose ≥110 mg/dl | 28% (260/934) | 82% (286/348) | <0.001 |
| Haemoglobin A1c ≥7.0%b | 3% (31/1179) | 57% (215/378) | <0.001 |
| Hyperlipidaemia | 77% (1029/1341) | 82% (362/444) | 0.035 |
| Medically treated diabetes | 0% (0/1348) | 100% (452/452) | <0.001 |
| Insulin-requiring diabetes | 0% (0/1348) | 40% (182/452) | <0.001 |
| Cardiovascular history | |||
| Current smoker | 22% (292/1343) | 16% (71/450) | 0.006 |
| Prior myocardial infarction | 33% (442/1333) | 32% (143/447) | 0.65 |
| Congestive heart failure | 4% (50/1334) | 7% (33/444) | 0.001 |
| Carotid artery disease | 7% (99/1348) | 11% (49/452) | 0.019 |
| Prior cerebrovascular accident | 4% (51/1341) | 6% (27/448) | 0.046 |
| Prior transient ischaemic attack | 4% (58/1341) | 6% (26/448) | 0.20 |
| Peripheral vascular disease | 8% (111/1348) | 15% (66/452) | <0.001 |
| Creatinine >200 μmol/l | 1% (13/1348) | 3% (13/452) | 0.003 |
| Unstable angina | 28% (378/1348) | 30% (134/452) | 0.51 |
| LVEF <30%c | 2% (21/1348) | 3% (13/452) | 0.075 |
| Parsonnet score | 7.5 ± 6.8 | 11.3 ± 6.4 | <0.001 |
| Additive EuroSCOREd | 3.7 ± 2.6 | 4.0 ± 2.7 | 0.027 |
| Lesion complexity | |||
| Diffuse disease or small vesselsb | 10% (136/1338) | 13% (60/449) | 0.061 |
| SYNTAX scoreb | 28.6 ± 11.5 | 29.0 ± 11.2 | 0.52 |
| Lesion characteristics | |||
| Number of lesionsb | 4.3 ± 1.8 | 4.6 ± 1.8 | 0.003 |
| Left main, anyb | 36% (480/1338) | 29% (130/449) | 0.007 |
| Left main only | 4% (52/1338) | 2% (10/449) | 0.096 |
| Left main + 1-vessel | 6% (75/1338) | 4% (18/449) | 0.19 |
| Left main + 2-vessel | 12% (160/1338) | 11% (50/449) | 0.64 |
| Left main + 3-vessel | 14% (193/1338) | 12% (52/449) | 0.13 |
| Three-vessel disease onlyb | 64% (858/1338) | 71% (319/449) | 0.007 |
| . | Non-diabetic (n = 1348) . | Diabetic (n = 452) . | P-value . |
|---|---|---|---|
| Age (years) | 65.0 ± 9.9 (1348) | 65.4 ± 9.2 | 0.049 |
| Male gender | 79.9 (1077/1348) | 71.0 (321/452) | <0.001 |
| Comorbid risk factors | |||
| Body mass index (kg/m2) | 27.5 ± 4.4 | 29.5 ± 5.2 | <0.001 |
| Metabolic syndromea | 37% (398/1064) | 70% (258/369) | <0.001 |
| Waist >40 in. for male, >35 in. for female | 42% (502/1194) | 61% (238/393) | <0.001 |
| Triglycerides ≥150 mg/dlb | 33% (409/1230) | 42% (170/408) | 0.002 |
| HDL <40 mg/dl male, <50 mg/dl femaleb | 45% (544/1199) | 61% (238/389) | <0.001 |
| Blood pressure ≥130/85 mmHg | 65% (80/1348) | 70% (316/452) | 0.071 |
| Fasting glucose ≥110 mg/dl | 28% (260/934) | 82% (286/348) | <0.001 |
| Haemoglobin A1c ≥7.0%b | 3% (31/1179) | 57% (215/378) | <0.001 |
| Hyperlipidaemia | 77% (1029/1341) | 82% (362/444) | 0.035 |
| Medically treated diabetes | 0% (0/1348) | 100% (452/452) | <0.001 |
| Insulin-requiring diabetes | 0% (0/1348) | 40% (182/452) | <0.001 |
| Cardiovascular history | |||
| Current smoker | 22% (292/1343) | 16% (71/450) | 0.006 |
| Prior myocardial infarction | 33% (442/1333) | 32% (143/447) | 0.65 |
| Congestive heart failure | 4% (50/1334) | 7% (33/444) | 0.001 |
| Carotid artery disease | 7% (99/1348) | 11% (49/452) | 0.019 |
| Prior cerebrovascular accident | 4% (51/1341) | 6% (27/448) | 0.046 |
| Prior transient ischaemic attack | 4% (58/1341) | 6% (26/448) | 0.20 |
| Peripheral vascular disease | 8% (111/1348) | 15% (66/452) | <0.001 |
| Creatinine >200 μmol/l | 1% (13/1348) | 3% (13/452) | 0.003 |
| Unstable angina | 28% (378/1348) | 30% (134/452) | 0.51 |
| LVEF <30%c | 2% (21/1348) | 3% (13/452) | 0.075 |
| Parsonnet score | 7.5 ± 6.8 | 11.3 ± 6.4 | <0.001 |
| Additive EuroSCOREd | 3.7 ± 2.6 | 4.0 ± 2.7 | 0.027 |
| Lesion complexity | |||
| Diffuse disease or small vesselsb | 10% (136/1338) | 13% (60/449) | 0.061 |
| SYNTAX scoreb | 28.6 ± 11.5 | 29.0 ± 11.2 | 0.52 |
| Lesion characteristics | |||
| Number of lesionsb | 4.3 ± 1.8 | 4.6 ± 1.8 | 0.003 |
| Left main, anyb | 36% (480/1338) | 29% (130/449) | 0.007 |
| Left main only | 4% (52/1338) | 2% (10/449) | 0.096 |
| Left main + 1-vessel | 6% (75/1338) | 4% (18/449) | 0.19 |
| Left main + 2-vessel | 12% (160/1338) | 11% (50/449) | 0.64 |
| Left main + 3-vessel | 14% (193/1338) | 12% (52/449) | 0.13 |
| Three-vessel disease onlyb | 64% (858/1338) | 71% (319/449) | 0.007 |
Values are shown as mean ± SD (n) or % (n/N). Reprinted from Ref. [8].
HDL: high-density lipoprotein; LVEF: left ventricular ejection fraction.
aMetabolic syndrome was defined as at least three of the following: (i) waist circumference >40 in. for male or >35 in. for female; (ii) triglycerides ≥150 mg/dl; (iii) high-density lipoprotein <40 mg/dl for male or <50 mg/dl for female; (iv) blood pressure ≥130/85 mmHg and (v) fasting glucose ≥110 mg/dl [25].
bCore laboratory reported.
cOr indicated by clinical site as ‘poor’ if exact value was not available.
dAdditive EuroSCORE calculated from site-reported baseline data.
| . | Non-diabetic (n = 1348) . | Diabetic (n = 452) . | P-value . |
|---|---|---|---|
| Age (years) | 65.0 ± 9.9 (1348) | 65.4 ± 9.2 | 0.049 |
| Male gender | 79.9 (1077/1348) | 71.0 (321/452) | <0.001 |
| Comorbid risk factors | |||
| Body mass index (kg/m2) | 27.5 ± 4.4 | 29.5 ± 5.2 | <0.001 |
| Metabolic syndromea | 37% (398/1064) | 70% (258/369) | <0.001 |
| Waist >40 in. for male, >35 in. for female | 42% (502/1194) | 61% (238/393) | <0.001 |
| Triglycerides ≥150 mg/dlb | 33% (409/1230) | 42% (170/408) | 0.002 |
| HDL <40 mg/dl male, <50 mg/dl femaleb | 45% (544/1199) | 61% (238/389) | <0.001 |
| Blood pressure ≥130/85 mmHg | 65% (80/1348) | 70% (316/452) | 0.071 |
| Fasting glucose ≥110 mg/dl | 28% (260/934) | 82% (286/348) | <0.001 |
| Haemoglobin A1c ≥7.0%b | 3% (31/1179) | 57% (215/378) | <0.001 |
| Hyperlipidaemia | 77% (1029/1341) | 82% (362/444) | 0.035 |
| Medically treated diabetes | 0% (0/1348) | 100% (452/452) | <0.001 |
| Insulin-requiring diabetes | 0% (0/1348) | 40% (182/452) | <0.001 |
| Cardiovascular history | |||
| Current smoker | 22% (292/1343) | 16% (71/450) | 0.006 |
| Prior myocardial infarction | 33% (442/1333) | 32% (143/447) | 0.65 |
| Congestive heart failure | 4% (50/1334) | 7% (33/444) | 0.001 |
| Carotid artery disease | 7% (99/1348) | 11% (49/452) | 0.019 |
| Prior cerebrovascular accident | 4% (51/1341) | 6% (27/448) | 0.046 |
| Prior transient ischaemic attack | 4% (58/1341) | 6% (26/448) | 0.20 |
| Peripheral vascular disease | 8% (111/1348) | 15% (66/452) | <0.001 |
| Creatinine >200 μmol/l | 1% (13/1348) | 3% (13/452) | 0.003 |
| Unstable angina | 28% (378/1348) | 30% (134/452) | 0.51 |
| LVEF <30%c | 2% (21/1348) | 3% (13/452) | 0.075 |
| Parsonnet score | 7.5 ± 6.8 | 11.3 ± 6.4 | <0.001 |
| Additive EuroSCOREd | 3.7 ± 2.6 | 4.0 ± 2.7 | 0.027 |
| Lesion complexity | |||
| Diffuse disease or small vesselsb | 10% (136/1338) | 13% (60/449) | 0.061 |
| SYNTAX scoreb | 28.6 ± 11.5 | 29.0 ± 11.2 | 0.52 |
| Lesion characteristics | |||
| Number of lesionsb | 4.3 ± 1.8 | 4.6 ± 1.8 | 0.003 |
| Left main, anyb | 36% (480/1338) | 29% (130/449) | 0.007 |
| Left main only | 4% (52/1338) | 2% (10/449) | 0.096 |
| Left main + 1-vessel | 6% (75/1338) | 4% (18/449) | 0.19 |
| Left main + 2-vessel | 12% (160/1338) | 11% (50/449) | 0.64 |
| Left main + 3-vessel | 14% (193/1338) | 12% (52/449) | 0.13 |
| Three-vessel disease onlyb | 64% (858/1338) | 71% (319/449) | 0.007 |
| . | Non-diabetic (n = 1348) . | Diabetic (n = 452) . | P-value . |
|---|---|---|---|
| Age (years) | 65.0 ± 9.9 (1348) | 65.4 ± 9.2 | 0.049 |
| Male gender | 79.9 (1077/1348) | 71.0 (321/452) | <0.001 |
| Comorbid risk factors | |||
| Body mass index (kg/m2) | 27.5 ± 4.4 | 29.5 ± 5.2 | <0.001 |
| Metabolic syndromea | 37% (398/1064) | 70% (258/369) | <0.001 |
| Waist >40 in. for male, >35 in. for female | 42% (502/1194) | 61% (238/393) | <0.001 |
| Triglycerides ≥150 mg/dlb | 33% (409/1230) | 42% (170/408) | 0.002 |
| HDL <40 mg/dl male, <50 mg/dl femaleb | 45% (544/1199) | 61% (238/389) | <0.001 |
| Blood pressure ≥130/85 mmHg | 65% (80/1348) | 70% (316/452) | 0.071 |
| Fasting glucose ≥110 mg/dl | 28% (260/934) | 82% (286/348) | <0.001 |
| Haemoglobin A1c ≥7.0%b | 3% (31/1179) | 57% (215/378) | <0.001 |
| Hyperlipidaemia | 77% (1029/1341) | 82% (362/444) | 0.035 |
| Medically treated diabetes | 0% (0/1348) | 100% (452/452) | <0.001 |
| Insulin-requiring diabetes | 0% (0/1348) | 40% (182/452) | <0.001 |
| Cardiovascular history | |||
| Current smoker | 22% (292/1343) | 16% (71/450) | 0.006 |
| Prior myocardial infarction | 33% (442/1333) | 32% (143/447) | 0.65 |
| Congestive heart failure | 4% (50/1334) | 7% (33/444) | 0.001 |
| Carotid artery disease | 7% (99/1348) | 11% (49/452) | 0.019 |
| Prior cerebrovascular accident | 4% (51/1341) | 6% (27/448) | 0.046 |
| Prior transient ischaemic attack | 4% (58/1341) | 6% (26/448) | 0.20 |
| Peripheral vascular disease | 8% (111/1348) | 15% (66/452) | <0.001 |
| Creatinine >200 μmol/l | 1% (13/1348) | 3% (13/452) | 0.003 |
| Unstable angina | 28% (378/1348) | 30% (134/452) | 0.51 |
| LVEF <30%c | 2% (21/1348) | 3% (13/452) | 0.075 |
| Parsonnet score | 7.5 ± 6.8 | 11.3 ± 6.4 | <0.001 |
| Additive EuroSCOREd | 3.7 ± 2.6 | 4.0 ± 2.7 | 0.027 |
| Lesion complexity | |||
| Diffuse disease or small vesselsb | 10% (136/1338) | 13% (60/449) | 0.061 |
| SYNTAX scoreb | 28.6 ± 11.5 | 29.0 ± 11.2 | 0.52 |
| Lesion characteristics | |||
| Number of lesionsb | 4.3 ± 1.8 | 4.6 ± 1.8 | 0.003 |
| Left main, anyb | 36% (480/1338) | 29% (130/449) | 0.007 |
| Left main only | 4% (52/1338) | 2% (10/449) | 0.096 |
| Left main + 1-vessel | 6% (75/1338) | 4% (18/449) | 0.19 |
| Left main + 2-vessel | 12% (160/1338) | 11% (50/449) | 0.64 |
| Left main + 3-vessel | 14% (193/1338) | 12% (52/449) | 0.13 |
| Three-vessel disease onlyb | 64% (858/1338) | 71% (319/449) | 0.007 |
Values are shown as mean ± SD (n) or % (n/N). Reprinted from Ref. [8].
HDL: high-density lipoprotein; LVEF: left ventricular ejection fraction.
aMetabolic syndrome was defined as at least three of the following: (i) waist circumference >40 in. for male or >35 in. for female; (ii) triglycerides ≥150 mg/dl; (iii) high-density lipoprotein <40 mg/dl for male or <50 mg/dl for female; (iv) blood pressure ≥130/85 mmHg and (v) fasting glucose ≥110 mg/dl [25].
bCore laboratory reported.
cOr indicated by clinical site as ‘poor’ if exact value was not available.
dAdditive EuroSCORE calculated from site-reported baseline data.
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