Characteristics of donors and transplant outcome according to initially measured lung water content
| Parameters . | EVLWI ≤10 ml kg−1 (n = 16) . | EVLWI > 10 ml kg−1 (n = 44) . | P-value . |
|---|---|---|---|
| Age (years) | 45.3 (29) | 41.2 (19) | 0.29 |
| Gender (female) | 21 | 10 | 0.39 |
| Positive smoking history | 14 (32%) | 6 (38%) | 0.04 |
| Cause of death | |||
| Head injury | 10 | 4 | 0.41 |
| Central nervous system infection | 1 | 2 | |
| Hypoxic brain injury | 2 | 1 | |
| Vascular/tumour | 31 | 9 | |
| Time from coning | 12.7 (8.2) | 13.1 (6.9) | 0.87 |
| Initial EVLWI-T | 7.6 (1.6) | 15.6 (4.7) | <0.001 |
| Δ-EVLWI-T | −1.3 (1.7) | −0.25 (5.1) | 0.22 |
| PaO2:FiO2 ratio | 387 (75) | 428 (83) | 0.08 |
| Δ-PaO2:FiO2 ratio | 4.3 (15.9) | 7.2 (20.8) | 0.58 |
| PVPI | 2.1 (0.4) | 3.4 (1.3) | <0.001 |
| Δ-PVPI | −0.19 (0.5) | −0.48 (1.5) | 0.28 |
| Initial pulmonary vascular resistance | 111 (66) | 161 (67) | 0.11 |
| Δ-PVR | −20.3 (100) | 21.2 (66) | 0.16 |
| PCWP | 7.4 (3.6) | 11.3 (6.9) | 0.008 |
| Δ-PCWP | −2.3 (5.2) | −3.9 (3.9) | 0.31 |
| Norepinephrine dose (µg kg−1 min−2) | 0.13 (0.03) | 0.25 (0.06) | <0.001 |
| Norepinephrine > 0.06 µg kg−1 min−2 | 14/44 | 6/16 | 0.04 |
| Positive bronchoalveolar lavage culture | 27/39 | 11/13 | 0.47 |
| Time from initial EVLWI to retrieval assessment (h) | 6.5 (1.2) | 7.1 (1.2) | 0.09 |
| Lungs matching suitability | 27/44 | 3/16 | 0.007 |
| Parameters . | EVLWI ≤10 ml kg−1 (n = 16) . | EVLWI > 10 ml kg−1 (n = 44) . | P-value . |
|---|---|---|---|
| Age (years) | 45.3 (29) | 41.2 (19) | 0.29 |
| Gender (female) | 21 | 10 | 0.39 |
| Positive smoking history | 14 (32%) | 6 (38%) | 0.04 |
| Cause of death | |||
| Head injury | 10 | 4 | 0.41 |
| Central nervous system infection | 1 | 2 | |
| Hypoxic brain injury | 2 | 1 | |
| Vascular/tumour | 31 | 9 | |
| Time from coning | 12.7 (8.2) | 13.1 (6.9) | 0.87 |
| Initial EVLWI-T | 7.6 (1.6) | 15.6 (4.7) | <0.001 |
| Δ-EVLWI-T | −1.3 (1.7) | −0.25 (5.1) | 0.22 |
| PaO2:FiO2 ratio | 387 (75) | 428 (83) | 0.08 |
| Δ-PaO2:FiO2 ratio | 4.3 (15.9) | 7.2 (20.8) | 0.58 |
| PVPI | 2.1 (0.4) | 3.4 (1.3) | <0.001 |
| Δ-PVPI | −0.19 (0.5) | −0.48 (1.5) | 0.28 |
| Initial pulmonary vascular resistance | 111 (66) | 161 (67) | 0.11 |
| Δ-PVR | −20.3 (100) | 21.2 (66) | 0.16 |
| PCWP | 7.4 (3.6) | 11.3 (6.9) | 0.008 |
| Δ-PCWP | −2.3 (5.2) | −3.9 (3.9) | 0.31 |
| Norepinephrine dose (µg kg−1 min−2) | 0.13 (0.03) | 0.25 (0.06) | <0.001 |
| Norepinephrine > 0.06 µg kg−1 min−2 | 14/44 | 6/16 | 0.04 |
| Positive bronchoalveolar lavage culture | 27/39 | 11/13 | 0.47 |
| Time from initial EVLWI to retrieval assessment (h) | 6.5 (1.2) | 7.1 (1.2) | 0.09 |
| Lungs matching suitability | 27/44 | 3/16 | 0.007 |
The assessment time represents the period between initial and final measurements. The prefix Δ indicates the change in measurement between final and initial sampling. Lungs matching suitability indicates those attaining the predefined transplant suitability criteria (see text).
PVPI: pulmonary vascular permeability index: PCWP: initial pulmonary capillary wedge pressure.
Characteristics of donors and transplant outcome according to initially measured lung water content
| Parameters . | EVLWI ≤10 ml kg−1 (n = 16) . | EVLWI > 10 ml kg−1 (n = 44) . | P-value . |
|---|---|---|---|
| Age (years) | 45.3 (29) | 41.2 (19) | 0.29 |
| Gender (female) | 21 | 10 | 0.39 |
| Positive smoking history | 14 (32%) | 6 (38%) | 0.04 |
| Cause of death | |||
| Head injury | 10 | 4 | 0.41 |
| Central nervous system infection | 1 | 2 | |
| Hypoxic brain injury | 2 | 1 | |
| Vascular/tumour | 31 | 9 | |
| Time from coning | 12.7 (8.2) | 13.1 (6.9) | 0.87 |
| Initial EVLWI-T | 7.6 (1.6) | 15.6 (4.7) | <0.001 |
| Δ-EVLWI-T | −1.3 (1.7) | −0.25 (5.1) | 0.22 |
| PaO2:FiO2 ratio | 387 (75) | 428 (83) | 0.08 |
| Δ-PaO2:FiO2 ratio | 4.3 (15.9) | 7.2 (20.8) | 0.58 |
| PVPI | 2.1 (0.4) | 3.4 (1.3) | <0.001 |
| Δ-PVPI | −0.19 (0.5) | −0.48 (1.5) | 0.28 |
| Initial pulmonary vascular resistance | 111 (66) | 161 (67) | 0.11 |
| Δ-PVR | −20.3 (100) | 21.2 (66) | 0.16 |
| PCWP | 7.4 (3.6) | 11.3 (6.9) | 0.008 |
| Δ-PCWP | −2.3 (5.2) | −3.9 (3.9) | 0.31 |
| Norepinephrine dose (µg kg−1 min−2) | 0.13 (0.03) | 0.25 (0.06) | <0.001 |
| Norepinephrine > 0.06 µg kg−1 min−2 | 14/44 | 6/16 | 0.04 |
| Positive bronchoalveolar lavage culture | 27/39 | 11/13 | 0.47 |
| Time from initial EVLWI to retrieval assessment (h) | 6.5 (1.2) | 7.1 (1.2) | 0.09 |
| Lungs matching suitability | 27/44 | 3/16 | 0.007 |
| Parameters . | EVLWI ≤10 ml kg−1 (n = 16) . | EVLWI > 10 ml kg−1 (n = 44) . | P-value . |
|---|---|---|---|
| Age (years) | 45.3 (29) | 41.2 (19) | 0.29 |
| Gender (female) | 21 | 10 | 0.39 |
| Positive smoking history | 14 (32%) | 6 (38%) | 0.04 |
| Cause of death | |||
| Head injury | 10 | 4 | 0.41 |
| Central nervous system infection | 1 | 2 | |
| Hypoxic brain injury | 2 | 1 | |
| Vascular/tumour | 31 | 9 | |
| Time from coning | 12.7 (8.2) | 13.1 (6.9) | 0.87 |
| Initial EVLWI-T | 7.6 (1.6) | 15.6 (4.7) | <0.001 |
| Δ-EVLWI-T | −1.3 (1.7) | −0.25 (5.1) | 0.22 |
| PaO2:FiO2 ratio | 387 (75) | 428 (83) | 0.08 |
| Δ-PaO2:FiO2 ratio | 4.3 (15.9) | 7.2 (20.8) | 0.58 |
| PVPI | 2.1 (0.4) | 3.4 (1.3) | <0.001 |
| Δ-PVPI | −0.19 (0.5) | −0.48 (1.5) | 0.28 |
| Initial pulmonary vascular resistance | 111 (66) | 161 (67) | 0.11 |
| Δ-PVR | −20.3 (100) | 21.2 (66) | 0.16 |
| PCWP | 7.4 (3.6) | 11.3 (6.9) | 0.008 |
| Δ-PCWP | −2.3 (5.2) | −3.9 (3.9) | 0.31 |
| Norepinephrine dose (µg kg−1 min−2) | 0.13 (0.03) | 0.25 (0.06) | <0.001 |
| Norepinephrine > 0.06 µg kg−1 min−2 | 14/44 | 6/16 | 0.04 |
| Positive bronchoalveolar lavage culture | 27/39 | 11/13 | 0.47 |
| Time from initial EVLWI to retrieval assessment (h) | 6.5 (1.2) | 7.1 (1.2) | 0.09 |
| Lungs matching suitability | 27/44 | 3/16 | 0.007 |
The assessment time represents the period between initial and final measurements. The prefix Δ indicates the change in measurement between final and initial sampling. Lungs matching suitability indicates those attaining the predefined transplant suitability criteria (see text).
PVPI: pulmonary vascular permeability index: PCWP: initial pulmonary capillary wedge pressure.
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