Table 2:
Open in new tab

Results of univariate Cox analysis for endpoint events

All-cause death [HR (95% CI, P-value)]COAG death [HR (95% CI, P-value)]COAG death/uHTx [HR (95% CI, P-value)]INF death [HR (95% CI, P-value)]INF death/uHTx [HR (95% CI, P-value)]
BSA < 1.867 m22.086 (1.361–3.197, 0.0007)2.665 (1.349–5.265; 0.0048)2.621 (1.474–4.660, 0.0010)1.572 (0.726–3.405, 0.25)1.063 (0.512–2.205, 0.87)
Age (years)1.040 (1.018–1.062, 0.0003)1.006 (0.976–1.036, 0.71)0.985 (0.962–1.007, 0.18)1.077 (1.033–1.123, 0.0005)1.027 (0.998–1.058, 0.065)
INTERMACS level 2a1.808 (1.081–3.024, 0.024)1.646 (0.709–3.820, 0.25)2.338 (1.199–4.560, 0.013)1.575 (0.640–3.879, 0.32)1.387 (0.572–3.367, 0.47)
Albumin (g/dl)0.683 (0.458–1.020, 0.062)0.802 (0.415–1.548, 0.51)1.211 (0.705–2.081, 0.49)0.509 (0.255–1.018, 0.056)0.748 (0.423–1.324, 0.32)
Body mass index (kg/m2)0.967 (0.921–1.014, 0.17)0.934 (0.860–1.014, 0.10)0.933 (0.871–0.999, 0.045)0.978 (0.900–1.062, 0.59)0.999 (0.936–1.067, 0.98)
Female gender1.343 (0.697–2.587, 0.38)1.445 (0.510–4.099, 0.49)1.569 (0.668–3.687, 0.30)0.368 (0.050–2.697, 0.33)0.273 (0.038–1.986, 0.20)
Serum creatinine (mg/dl)1.102 (0.804–1.512, 0.55)0.611 (0.315–1.185, 0.15)0.835 (0.508–1.373, 0.48)1.298 (0.786–2.144, 0.31)1.167 (0.742–1.835, 0.51)
Indication for LVAD
 Bridge to transplant11111
 Bridge to candidacy1.357 (0.825–2.231, 0.23)2.281 (0.997–5.219, 0.051)1.460 (0.787– 2.709, 0.23)0.377 (0.134–1.060, 0.064)0.531 (0.257–1.097, 0.087)
 Bridge to recovery1.894 (0.823–4.360, 0.13)1.736 (0.367–8.202, 0.49)0.881 (0.203–3.827, 0.87)2.170 (0.705–6.683, 0.18)1.402 (0.481–4.086, 0.54)
Destination therapy2.158 (1.258–3.702, 0.0052)1.656 (0.574–4.779, 0.35)0.799 (0.315–2.028, 0.64)1.907 (0.853–4.265, 0.12)1.156 (0.560–2.388, 0.69)
Surgical approach
 Primary sternotomy11111
 Re-sternotomy1.355 (0.730–2.514, 0.34)0.783 (0.237–2.585, 0.69)0.749 (0.267– 2.097, 0.58)1.469 (0.499–4.326, 0.48)1.387 (0.578–3.330, 0.46)
 Left lateral thoracotomy1.713 (1.053–2.788, 0.030)0.912 (0.351– 2.370, 0.85)0.887 (0.396–1.984, 0.77)2.548 (1.184–5.484, 0.017)1.744 (0.875–3.474, 0.11)
All-cause death [HR (95% CI, P-value)]COAG death [HR (95% CI, P-value)]COAG death/uHTx [HR (95% CI, P-value)]INF death [HR (95% CI, P-value)]INF death/uHTx [HR (95% CI, P-value)]
BSA < 1.867 m22.086 (1.361–3.197, 0.0007)2.665 (1.349–5.265; 0.0048)2.621 (1.474–4.660, 0.0010)1.572 (0.726–3.405, 0.25)1.063 (0.512–2.205, 0.87)
Age (years)1.040 (1.018–1.062, 0.0003)1.006 (0.976–1.036, 0.71)0.985 (0.962–1.007, 0.18)1.077 (1.033–1.123, 0.0005)1.027 (0.998–1.058, 0.065)
INTERMACS level 2a1.808 (1.081–3.024, 0.024)1.646 (0.709–3.820, 0.25)2.338 (1.199–4.560, 0.013)1.575 (0.640–3.879, 0.32)1.387 (0.572–3.367, 0.47)
Albumin (g/dl)0.683 (0.458–1.020, 0.062)0.802 (0.415–1.548, 0.51)1.211 (0.705–2.081, 0.49)0.509 (0.255–1.018, 0.056)0.748 (0.423–1.324, 0.32)
Body mass index (kg/m2)0.967 (0.921–1.014, 0.17)0.934 (0.860–1.014, 0.10)0.933 (0.871–0.999, 0.045)0.978 (0.900–1.062, 0.59)0.999 (0.936–1.067, 0.98)
Female gender1.343 (0.697–2.587, 0.38)1.445 (0.510–4.099, 0.49)1.569 (0.668–3.687, 0.30)0.368 (0.050–2.697, 0.33)0.273 (0.038–1.986, 0.20)
Serum creatinine (mg/dl)1.102 (0.804–1.512, 0.55)0.611 (0.315–1.185, 0.15)0.835 (0.508–1.373, 0.48)1.298 (0.786–2.144, 0.31)1.167 (0.742–1.835, 0.51)
Indication for LVAD
 Bridge to transplant11111
 Bridge to candidacy1.357 (0.825–2.231, 0.23)2.281 (0.997–5.219, 0.051)1.460 (0.787– 2.709, 0.23)0.377 (0.134–1.060, 0.064)0.531 (0.257–1.097, 0.087)
 Bridge to recovery1.894 (0.823–4.360, 0.13)1.736 (0.367–8.202, 0.49)0.881 (0.203–3.827, 0.87)2.170 (0.705–6.683, 0.18)1.402 (0.481–4.086, 0.54)
Destination therapy2.158 (1.258–3.702, 0.0052)1.656 (0.574–4.779, 0.35)0.799 (0.315–2.028, 0.64)1.907 (0.853–4.265, 0.12)1.156 (0.560–2.388, 0.69)
Surgical approach
 Primary sternotomy11111
 Re-sternotomy1.355 (0.730–2.514, 0.34)0.783 (0.237–2.585, 0.69)0.749 (0.267– 2.097, 0.58)1.469 (0.499–4.326, 0.48)1.387 (0.578–3.330, 0.46)
 Left lateral thoracotomy1.713 (1.053–2.788, 0.030)0.912 (0.351– 2.370, 0.85)0.887 (0.396–1.984, 0.77)2.548 (1.184–5.484, 0.017)1.744 (0.875–3.474, 0.11)

CI: confidence interval; COAG death: death due to stroke or systemic bleeding; COAG death/uHTx: death due to stroke or systemic bleeding, or urgent heart transplantation due to difficulties of coagulation management (i.e. embolic events or bleeding); HR: hazard ratio; INF death: death due to sepsis; INF death/uHTx: death due to sepsis, or urgent heart transplantation due to device infection.

aINTERMACS level 2 vs levels 3 and 4. P-values less than 0.10 are shown in bold.

Table 2:
Open in new tab

Results of univariate Cox analysis for endpoint events

All-cause death [HR (95% CI, P-value)]COAG death [HR (95% CI, P-value)]COAG death/uHTx [HR (95% CI, P-value)]INF death [HR (95% CI, P-value)]INF death/uHTx [HR (95% CI, P-value)]
BSA < 1.867 m22.086 (1.361–3.197, 0.0007)2.665 (1.349–5.265; 0.0048)2.621 (1.474–4.660, 0.0010)1.572 (0.726–3.405, 0.25)1.063 (0.512–2.205, 0.87)
Age (years)1.040 (1.018–1.062, 0.0003)1.006 (0.976–1.036, 0.71)0.985 (0.962–1.007, 0.18)1.077 (1.033–1.123, 0.0005)1.027 (0.998–1.058, 0.065)
INTERMACS level 2a1.808 (1.081–3.024, 0.024)1.646 (0.709–3.820, 0.25)2.338 (1.199–4.560, 0.013)1.575 (0.640–3.879, 0.32)1.387 (0.572–3.367, 0.47)
Albumin (g/dl)0.683 (0.458–1.020, 0.062)0.802 (0.415–1.548, 0.51)1.211 (0.705–2.081, 0.49)0.509 (0.255–1.018, 0.056)0.748 (0.423–1.324, 0.32)
Body mass index (kg/m2)0.967 (0.921–1.014, 0.17)0.934 (0.860–1.014, 0.10)0.933 (0.871–0.999, 0.045)0.978 (0.900–1.062, 0.59)0.999 (0.936–1.067, 0.98)
Female gender1.343 (0.697–2.587, 0.38)1.445 (0.510–4.099, 0.49)1.569 (0.668–3.687, 0.30)0.368 (0.050–2.697, 0.33)0.273 (0.038–1.986, 0.20)
Serum creatinine (mg/dl)1.102 (0.804–1.512, 0.55)0.611 (0.315–1.185, 0.15)0.835 (0.508–1.373, 0.48)1.298 (0.786–2.144, 0.31)1.167 (0.742–1.835, 0.51)
Indication for LVAD
 Bridge to transplant11111
 Bridge to candidacy1.357 (0.825–2.231, 0.23)2.281 (0.997–5.219, 0.051)1.460 (0.787– 2.709, 0.23)0.377 (0.134–1.060, 0.064)0.531 (0.257–1.097, 0.087)
 Bridge to recovery1.894 (0.823–4.360, 0.13)1.736 (0.367–8.202, 0.49)0.881 (0.203–3.827, 0.87)2.170 (0.705–6.683, 0.18)1.402 (0.481–4.086, 0.54)
Destination therapy2.158 (1.258–3.702, 0.0052)1.656 (0.574–4.779, 0.35)0.799 (0.315–2.028, 0.64)1.907 (0.853–4.265, 0.12)1.156 (0.560–2.388, 0.69)
Surgical approach
 Primary sternotomy11111
 Re-sternotomy1.355 (0.730–2.514, 0.34)0.783 (0.237–2.585, 0.69)0.749 (0.267– 2.097, 0.58)1.469 (0.499–4.326, 0.48)1.387 (0.578–3.330, 0.46)
 Left lateral thoracotomy1.713 (1.053–2.788, 0.030)0.912 (0.351– 2.370, 0.85)0.887 (0.396–1.984, 0.77)2.548 (1.184–5.484, 0.017)1.744 (0.875–3.474, 0.11)
All-cause death [HR (95% CI, P-value)]COAG death [HR (95% CI, P-value)]COAG death/uHTx [HR (95% CI, P-value)]INF death [HR (95% CI, P-value)]INF death/uHTx [HR (95% CI, P-value)]
BSA < 1.867 m22.086 (1.361–3.197, 0.0007)2.665 (1.349–5.265; 0.0048)2.621 (1.474–4.660, 0.0010)1.572 (0.726–3.405, 0.25)1.063 (0.512–2.205, 0.87)
Age (years)1.040 (1.018–1.062, 0.0003)1.006 (0.976–1.036, 0.71)0.985 (0.962–1.007, 0.18)1.077 (1.033–1.123, 0.0005)1.027 (0.998–1.058, 0.065)
INTERMACS level 2a1.808 (1.081–3.024, 0.024)1.646 (0.709–3.820, 0.25)2.338 (1.199–4.560, 0.013)1.575 (0.640–3.879, 0.32)1.387 (0.572–3.367, 0.47)
Albumin (g/dl)0.683 (0.458–1.020, 0.062)0.802 (0.415–1.548, 0.51)1.211 (0.705–2.081, 0.49)0.509 (0.255–1.018, 0.056)0.748 (0.423–1.324, 0.32)
Body mass index (kg/m2)0.967 (0.921–1.014, 0.17)0.934 (0.860–1.014, 0.10)0.933 (0.871–0.999, 0.045)0.978 (0.900–1.062, 0.59)0.999 (0.936–1.067, 0.98)
Female gender1.343 (0.697–2.587, 0.38)1.445 (0.510–4.099, 0.49)1.569 (0.668–3.687, 0.30)0.368 (0.050–2.697, 0.33)0.273 (0.038–1.986, 0.20)
Serum creatinine (mg/dl)1.102 (0.804–1.512, 0.55)0.611 (0.315–1.185, 0.15)0.835 (0.508–1.373, 0.48)1.298 (0.786–2.144, 0.31)1.167 (0.742–1.835, 0.51)
Indication for LVAD
 Bridge to transplant11111
 Bridge to candidacy1.357 (0.825–2.231, 0.23)2.281 (0.997–5.219, 0.051)1.460 (0.787– 2.709, 0.23)0.377 (0.134–1.060, 0.064)0.531 (0.257–1.097, 0.087)
 Bridge to recovery1.894 (0.823–4.360, 0.13)1.736 (0.367–8.202, 0.49)0.881 (0.203–3.827, 0.87)2.170 (0.705–6.683, 0.18)1.402 (0.481–4.086, 0.54)
Destination therapy2.158 (1.258–3.702, 0.0052)1.656 (0.574–4.779, 0.35)0.799 (0.315–2.028, 0.64)1.907 (0.853–4.265, 0.12)1.156 (0.560–2.388, 0.69)
Surgical approach
 Primary sternotomy11111
 Re-sternotomy1.355 (0.730–2.514, 0.34)0.783 (0.237–2.585, 0.69)0.749 (0.267– 2.097, 0.58)1.469 (0.499–4.326, 0.48)1.387 (0.578–3.330, 0.46)
 Left lateral thoracotomy1.713 (1.053–2.788, 0.030)0.912 (0.351– 2.370, 0.85)0.887 (0.396–1.984, 0.77)2.548 (1.184–5.484, 0.017)1.744 (0.875–3.474, 0.11)

CI: confidence interval; COAG death: death due to stroke or systemic bleeding; COAG death/uHTx: death due to stroke or systemic bleeding, or urgent heart transplantation due to difficulties of coagulation management (i.e. embolic events or bleeding); HR: hazard ratio; INF death: death due to sepsis; INF death/uHTx: death due to sepsis, or urgent heart transplantation due to device infection.

aINTERMACS level 2 vs levels 3 and 4. P-values less than 0.10 are shown in bold.

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