Table 2: Open in new tab Univariate and...

	Hazard ratio	95% CI	P-value
Univariate analysis results
Age (>67)	1.1127	0.7937–1.5669	0.5340
Sex (female)	0.7922	0.5484–1.1166	0.1861
Smoking history (no)	0.8813	0.6155–1.2381	0.4700
CEA (>5)	3.4969	1.7800–6.9952	0.0003
Maximum tumour diameter measured in the lung window (>22.87)	1.6550	1.1746–2.3545	0.0036
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.6526	1.7992–4.1892	<.0001
Procedure			0.9262
Wedge resection	1
Lobectomy	0.8889	0.5230–1.7466
Segmentectomy	1.1827	0.3501–2.6496
Vessel invasion (yes)	5.7248	2.9146–11.450	<0.0001
Pleural invasion (yes)	4.6497	2.3666–9.3025	<0.0001
Lavage cytology (positive)	5.8025	1.3858–16.411	0.0205
1. Multivariate analysis results: tumour size assessment by one-dimensional measurement
CEA (>5)	2.5515	1.2737–5.1982	0.0084
Maximum tumour diameter measured in the lung window (>22.87)	0.8542	0.5684–1.3005	0.455
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.0830	1.2547–3.5846	0.0042
Vessel invasion (yes)	1.9875	0.9105–4.5147	0.0850
Pleural invasion (yes)	3.1140	1.4907–6.5355	0.0028
Lavage cytology (positive)	1.3536	0.3057–4.3067	0.6520
2. Multivariate analysis results: tumour size assessment by two-dimensional measurement
CEA (>5)	2.3043	1.1495–4.6962	0.0188
Area size measured in the mediastinal window (>90.3)	1.8700	1.1673–3.1138	0.0089
GGO area size (>167.0)	0.5507	0.2988–0.8834	0.0111
Vessel invasion (yes)	1.8771	0.8511–4.2975	0.1193
Pleural invasion (yes)	2.8057	1.3542–5.8451	0.0059
Lavage cytology (positive)	1.3990	0.3154–4.4551	0.6186
3. Multivariate analysis results: tumour size assessment by area size ratio (TDR)
CEA (>5)	2.4791	1.2506–5.0016	0.0095
TDR (>0.778)	0.3247	0.1293–0.6056	<0.0001
Vessel invasion (yes)	2.2617	1.0095–4.7257	0.0267
Pleural invasion (yes)	2.6987	1.3090–5.5957	0.0076
Lavage cytology (positive)	1.3301	0.3045–4.1136	0.6660

Hazard ratio

95% CI

P-value

Univariate analysis results

Age (>67)

1.1127

0.7937–1.5669

0.5340

Sex (female)

0.7922

0.5484–1.1166

0.1861

Smoking history (no)

0.8813

0.6155–1.2381

0.4700

CEA (>5)

3.4969

1.7800–6.9952

0.0003

Maximum tumour diameter measured in the lung window (>22.87)

1.6550

1.1746–2.3545

0.0036

Maximum tumour diameter measured in the mediastinal window (>12.52)

2.6526

1.7992–4.1892

<.0001

Procedure

0.9262

Wedge resection

Lobectomy

0.8889

0.5230–1.7466

Segmentectomy

1.1827

0.3501–2.6496

Vessel invasion (yes)

5.7248

2.9146–11.450

<0.0001

Pleural invasion (yes)

4.6497

2.3666–9.3025

<0.0001

Lavage cytology (positive)

5.8025

1.3858–16.411

0.0205

1. Multivariate analysis results: tumour size assessment by one-dimensional measurement

CEA (>5)

2.5515

1.2737–5.1982

0.0084

Maximum tumour diameter measured in the lung window (>22.87)

0.8542

0.5684–1.3005

0.455

Maximum tumour diameter measured in the mediastinal window (>12.52)

2.0830

1.2547–3.5846

0.0042

Vessel invasion (yes)

1.9875

0.9105–4.5147

0.0850

Pleural invasion (yes)

3.1140

1.4907–6.5355

0.0028

Lavage cytology (positive)

1.3536

0.3057–4.3067

0.6520

2. Multivariate analysis results: tumour size assessment by two-dimensional measurement

CEA (>5)

2.3043

1.1495–4.6962

0.0188

Area size measured in the mediastinal window (>90.3)

1.8700

1.1673–3.1138

0.0089

GGO area size (>167.0)

0.5507

0.2988–0.8834

0.0111

Vessel invasion (yes)

1.8771

0.8511–4.2975

0.1193

Pleural invasion (yes)

2.8057

1.3542–5.8451

0.0059

Lavage cytology (positive)

1.3990

0.3154–4.4551

0.6186

3. Multivariate analysis results: tumour size assessment by area size ratio (TDR)

CEA (>5)

2.4791

1.2506–5.0016

0.0095

TDR (>0.778)

0.3247

0.1293–0.6056

<0.0001

Vessel invasion (yes)

2.2617

1.0095–4.7257

0.0267

Pleural invasion (yes)

2.6987

1.3090–5.5957

0.0076

Lavage cytology (positive)

1.3301

0.3045–4.1136

0.6660

	Hazard ratio	95% CI	P-value
Univariate analysis results
Age (>67)	1.1127	0.7937–1.5669	0.5340
Sex (female)	0.7922	0.5484–1.1166	0.1861
Smoking history (no)	0.8813	0.6155–1.2381	0.4700
CEA (>5)	3.4969	1.7800–6.9952	0.0003
Maximum tumour diameter measured in the lung window (>22.87)	1.6550	1.1746–2.3545	0.0036
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.6526	1.7992–4.1892	<.0001
Procedure			0.9262
Wedge resection	1
Lobectomy	0.8889	0.5230–1.7466
Segmentectomy	1.1827	0.3501–2.6496
Vessel invasion (yes)	5.7248	2.9146–11.450	<0.0001
Pleural invasion (yes)	4.6497	2.3666–9.3025	<0.0001
Lavage cytology (positive)	5.8025	1.3858–16.411	0.0205
1. Multivariate analysis results: tumour size assessment by one-dimensional measurement
CEA (>5)	2.5515	1.2737–5.1982	0.0084
Maximum tumour diameter measured in the lung window (>22.87)	0.8542	0.5684–1.3005	0.455
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.0830	1.2547–3.5846	0.0042
Vessel invasion (yes)	1.9875	0.9105–4.5147	0.0850
Pleural invasion (yes)	3.1140	1.4907–6.5355	0.0028
Lavage cytology (positive)	1.3536	0.3057–4.3067	0.6520
2. Multivariate analysis results: tumour size assessment by two-dimensional measurement
CEA (>5)	2.3043	1.1495–4.6962	0.0188
Area size measured in the mediastinal window (>90.3)	1.8700	1.1673–3.1138	0.0089
GGO area size (>167.0)	0.5507	0.2988–0.8834	0.0111
Vessel invasion (yes)	1.8771	0.8511–4.2975	0.1193
Pleural invasion (yes)	2.8057	1.3542–5.8451	0.0059
Lavage cytology (positive)	1.3990	0.3154–4.4551	0.6186
3. Multivariate analysis results: tumour size assessment by area size ratio (TDR)
CEA (>5)	2.4791	1.2506–5.0016	0.0095
TDR (>0.778)	0.3247	0.1293–0.6056	<0.0001
Vessel invasion (yes)	2.2617	1.0095–4.7257	0.0267
Pleural invasion (yes)	2.6987	1.3090–5.5957	0.0076
Lavage cytology (positive)	1.3301	0.3045–4.1136	0.6660

Table 2:

Open in new tab

Univariate and multivariate analyses of recurrence-free survival (Cox proportional hazard model)

	Hazard ratio	95% CI	P-value
Univariate analysis results
Age (>67)	1.1127	0.7937–1.5669	0.5340
Sex (female)	0.7922	0.5484–1.1166	0.1861
Smoking history (no)	0.8813	0.6155–1.2381	0.4700
CEA (>5)	3.4969	1.7800–6.9952	0.0003
Maximum tumour diameter measured in the lung window (>22.87)	1.6550	1.1746–2.3545	0.0036
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.6526	1.7992–4.1892	<.0001
Procedure			0.9262
Wedge resection	1
Lobectomy	0.8889	0.5230–1.7466
Segmentectomy	1.1827	0.3501–2.6496
Vessel invasion (yes)	5.7248	2.9146–11.450	<0.0001
Pleural invasion (yes)	4.6497	2.3666–9.3025	<0.0001
Lavage cytology (positive)	5.8025	1.3858–16.411	0.0205
1. Multivariate analysis results: tumour size assessment by one-dimensional measurement
CEA (>5)	2.5515	1.2737–5.1982	0.0084
Maximum tumour diameter measured in the lung window (>22.87)	0.8542	0.5684–1.3005	0.455
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.0830	1.2547–3.5846	0.0042
Vessel invasion (yes)	1.9875	0.9105–4.5147	0.0850
Pleural invasion (yes)	3.1140	1.4907–6.5355	0.0028
Lavage cytology (positive)	1.3536	0.3057–4.3067	0.6520
2. Multivariate analysis results: tumour size assessment by two-dimensional measurement
CEA (>5)	2.3043	1.1495–4.6962	0.0188
Area size measured in the mediastinal window (>90.3)	1.8700	1.1673–3.1138	0.0089
GGO area size (>167.0)	0.5507	0.2988–0.8834	0.0111
Vessel invasion (yes)	1.8771	0.8511–4.2975	0.1193
Pleural invasion (yes)	2.8057	1.3542–5.8451	0.0059
Lavage cytology (positive)	1.3990	0.3154–4.4551	0.6186
3. Multivariate analysis results: tumour size assessment by area size ratio (TDR)
CEA (>5)	2.4791	1.2506–5.0016	0.0095
TDR (>0.778)	0.3247	0.1293–0.6056	<0.0001
Vessel invasion (yes)	2.2617	1.0095–4.7257	0.0267
Pleural invasion (yes)	2.6987	1.3090–5.5957	0.0076
Lavage cytology (positive)	1.3301	0.3045–4.1136	0.6660

	Hazard ratio	95% CI	P-value
Univariate analysis results
Age (>67)	1.1127	0.7937–1.5669	0.5340
Sex (female)	0.7922	0.5484–1.1166	0.1861
Smoking history (no)	0.8813	0.6155–1.2381	0.4700
CEA (>5)	3.4969	1.7800–6.9952	0.0003
Maximum tumour diameter measured in the lung window (>22.87)	1.6550	1.1746–2.3545	0.0036
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.6526	1.7992–4.1892	<.0001
Procedure			0.9262
Wedge resection	1
Lobectomy	0.8889	0.5230–1.7466
Segmentectomy	1.1827	0.3501–2.6496
Vessel invasion (yes)	5.7248	2.9146–11.450	<0.0001
Pleural invasion (yes)	4.6497	2.3666–9.3025	<0.0001
Lavage cytology (positive)	5.8025	1.3858–16.411	0.0205
1. Multivariate analysis results: tumour size assessment by one-dimensional measurement
CEA (>5)	2.5515	1.2737–5.1982	0.0084
Maximum tumour diameter measured in the lung window (>22.87)	0.8542	0.5684–1.3005	0.455
Maximum tumour diameter measured in the mediastinal window (>12.52)	2.0830	1.2547–3.5846	0.0042
Vessel invasion (yes)	1.9875	0.9105–4.5147	0.0850
Pleural invasion (yes)	3.1140	1.4907–6.5355	0.0028
Lavage cytology (positive)	1.3536	0.3057–4.3067	0.6520
2. Multivariate analysis results: tumour size assessment by two-dimensional measurement
CEA (>5)	2.3043	1.1495–4.6962	0.0188
Area size measured in the mediastinal window (>90.3)	1.8700	1.1673–3.1138	0.0089
GGO area size (>167.0)	0.5507	0.2988–0.8834	0.0111
Vessel invasion (yes)	1.8771	0.8511–4.2975	0.1193
Pleural invasion (yes)	2.8057	1.3542–5.8451	0.0059
Lavage cytology (positive)	1.3990	0.3154–4.4551	0.6186
3. Multivariate analysis results: tumour size assessment by area size ratio (TDR)
CEA (>5)	2.4791	1.2506–5.0016	0.0095
TDR (>0.778)	0.3247	0.1293–0.6056	<0.0001
Vessel invasion (yes)	2.2617	1.0095–4.7257	0.0267
Pleural invasion (yes)	2.6987	1.3090–5.5957	0.0076
Lavage cytology (positive)	1.3301	0.3045–4.1136	0.6660

TDR: tumour shadow disappearance rate; GGO: ground glass opacity; CEA: carcinoembryonic antigen; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma.

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