Baseline characteristics of the study patients, according to therapy groups
| Variables . | CRRT group (n = 15) . | Furosemide group (n = 15) . | Total (n = 30) . | P . |
|---|---|---|---|---|
| Age (years) | 37 ± 12.7 | 37 ± 12.4 | 37 ± 12.4 | 0.8 |
| Gender, number (%) | ||||
| Male | 9 (30.0) | 9 (30.0) | 18 (60.0) | 1 |
| Female | 6 (20.0) | 6 (20.0) | 12 (40.0) | 1 |
| Height (m) | 1.68 ± 10 | 1.69 ± 8.1 | 168 ± 8.9 | 0.7 |
| Weight (kg) | 65 ± 12.8 | 65 ± 11.8 | 65 ± 12.1 | 0.9 |
| Body mass index (kg/m2)a | 23 ± 3.8 | 23 ± 4.4 | 23 ± 4.0 | 0.9 |
| Comorbid features, number (%) | ||||
| Diabetes mellitus | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Myocardial infarction | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Hypertension | 1 (6.6) | 1 (6.6) | 2 (6.6) | 1 |
| Stroke | 2 (13.3) | 1 (6.6) | 3 (10.0) | 0.5 |
| Arteriosclerotic vascular disease | 9 (60.0) | 3 (20.0) | 12 (80.0) | 0.02 |
| Previous cardiac surgery | 12 (80.0) | 10 (66.6) | 22 (73.3) | 0.4 |
| Preoperative characteristics | ||||
| Oetiology of heart transplantation, number (%) | ||||
| Dilated cardiomyopathy | 10 (66.6) | 13 (86.6) | 23 (76.6) | 0.2 |
| Ischaemic cardiomyopathy | 4 (26.6) | 2 (13.3) | 6 (40.0) | 0.3 |
| Arrythmogenic right ventricular dysplasia | 1 (6.6) | 0 (0.0) | 1 (3.3) | 0.3 |
| Ejection fraction <30%, number (%) | 13 (86.6) | 12 (80.0) | 25 (83.3) | 0.6 |
| Paracorporeal ventricular assist device, number (%) | 8 (53.3) | 10 (66.6) | 18 (60.0) | 0.45 |
| Intraoperative characteristics | ||||
| Aortic cross-clamping time (min) | 70 ± 2.5 | 80 ± 6.6 | 70 ± 4.9 | 0.7 |
| Cardiopulmonary bypass duration (min) | 126 ± 17.3 | 109 ± 18.3 | 118 ± 19.3 | 0.01 |
| Transfusion requirement, unit (median IQR) | 6.5 (4.5, 10.0) | 4.0 (2.0, 6.0) | 4.0 (2.5, 8) | 0.05 |
| Postoperative characteristics | ||||
| eGFR before intervention (ml/min/1.73 m2) | 50 ± 7.2 | 52 ± 7.0 | 51 ± 7.1 | 0.3 |
| Serum creatinine before intervention (mg/dl) | 1.5 ± 0.3 | 1.1 ± 0.3 | 1.4 ± 0.4 | 0.2 |
| Acute tubular necrosis, number (%) | 7 (46.7) | 2 (13.3) | 9 (30.0) | 0.04 |
| Intervention duration (h) | 37 ± 22.5 | 48 | 43 ± 14.7 | 0.7 |
| Time to discharge (days) | 21 ± 21.0 | 19.6 ± 11.0 | 20 ± 16.5 | 0.8 |
| Heart transplant to discharge (days) | 15.2 ± 15.5 | 14.5 ± 9.8 | 14.9 ± 12.4 | 0.8 |
| Variables . | CRRT group (n = 15) . | Furosemide group (n = 15) . | Total (n = 30) . | P . |
|---|---|---|---|---|
| Age (years) | 37 ± 12.7 | 37 ± 12.4 | 37 ± 12.4 | 0.8 |
| Gender, number (%) | ||||
| Male | 9 (30.0) | 9 (30.0) | 18 (60.0) | 1 |
| Female | 6 (20.0) | 6 (20.0) | 12 (40.0) | 1 |
| Height (m) | 1.68 ± 10 | 1.69 ± 8.1 | 168 ± 8.9 | 0.7 |
| Weight (kg) | 65 ± 12.8 | 65 ± 11.8 | 65 ± 12.1 | 0.9 |
| Body mass index (kg/m2)a | 23 ± 3.8 | 23 ± 4.4 | 23 ± 4.0 | 0.9 |
| Comorbid features, number (%) | ||||
| Diabetes mellitus | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Myocardial infarction | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Hypertension | 1 (6.6) | 1 (6.6) | 2 (6.6) | 1 |
| Stroke | 2 (13.3) | 1 (6.6) | 3 (10.0) | 0.5 |
| Arteriosclerotic vascular disease | 9 (60.0) | 3 (20.0) | 12 (80.0) | 0.02 |
| Previous cardiac surgery | 12 (80.0) | 10 (66.6) | 22 (73.3) | 0.4 |
| Preoperative characteristics | ||||
| Oetiology of heart transplantation, number (%) | ||||
| Dilated cardiomyopathy | 10 (66.6) | 13 (86.6) | 23 (76.6) | 0.2 |
| Ischaemic cardiomyopathy | 4 (26.6) | 2 (13.3) | 6 (40.0) | 0.3 |
| Arrythmogenic right ventricular dysplasia | 1 (6.6) | 0 (0.0) | 1 (3.3) | 0.3 |
| Ejection fraction <30%, number (%) | 13 (86.6) | 12 (80.0) | 25 (83.3) | 0.6 |
| Paracorporeal ventricular assist device, number (%) | 8 (53.3) | 10 (66.6) | 18 (60.0) | 0.45 |
| Intraoperative characteristics | ||||
| Aortic cross-clamping time (min) | 70 ± 2.5 | 80 ± 6.6 | 70 ± 4.9 | 0.7 |
| Cardiopulmonary bypass duration (min) | 126 ± 17.3 | 109 ± 18.3 | 118 ± 19.3 | 0.01 |
| Transfusion requirement, unit (median IQR) | 6.5 (4.5, 10.0) | 4.0 (2.0, 6.0) | 4.0 (2.5, 8) | 0.05 |
| Postoperative characteristics | ||||
| eGFR before intervention (ml/min/1.73 m2) | 50 ± 7.2 | 52 ± 7.0 | 51 ± 7.1 | 0.3 |
| Serum creatinine before intervention (mg/dl) | 1.5 ± 0.3 | 1.1 ± 0.3 | 1.4 ± 0.4 | 0.2 |
| Acute tubular necrosis, number (%) | 7 (46.7) | 2 (13.3) | 9 (30.0) | 0.04 |
| Intervention duration (h) | 37 ± 22.5 | 48 | 43 ± 14.7 | 0.7 |
| Time to discharge (days) | 21 ± 21.0 | 19.6 ± 11.0 | 20 ± 16.5 | 0.8 |
| Heart transplant to discharge (days) | 15.2 ± 15.5 | 14.5 ± 9.8 | 14.9 ± 12.4 | 0.8 |
Plus–minus values are means ± SD. P values for continuous and categorical data variables were calculated with Student's t-test and chi-square test, respectively.
aThe body mass index is the weight in kilograms divided by the square of the height in metres.
CRRT: continuous renal replacement therapy; IQR: interquartile range; eGFR: estimated glomerular filtration rate.
Baseline characteristics of the study patients, according to therapy groups
| Variables . | CRRT group (n = 15) . | Furosemide group (n = 15) . | Total (n = 30) . | P . |
|---|---|---|---|---|
| Age (years) | 37 ± 12.7 | 37 ± 12.4 | 37 ± 12.4 | 0.8 |
| Gender, number (%) | ||||
| Male | 9 (30.0) | 9 (30.0) | 18 (60.0) | 1 |
| Female | 6 (20.0) | 6 (20.0) | 12 (40.0) | 1 |
| Height (m) | 1.68 ± 10 | 1.69 ± 8.1 | 168 ± 8.9 | 0.7 |
| Weight (kg) | 65 ± 12.8 | 65 ± 11.8 | 65 ± 12.1 | 0.9 |
| Body mass index (kg/m2)a | 23 ± 3.8 | 23 ± 4.4 | 23 ± 4.0 | 0.9 |
| Comorbid features, number (%) | ||||
| Diabetes mellitus | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Myocardial infarction | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Hypertension | 1 (6.6) | 1 (6.6) | 2 (6.6) | 1 |
| Stroke | 2 (13.3) | 1 (6.6) | 3 (10.0) | 0.5 |
| Arteriosclerotic vascular disease | 9 (60.0) | 3 (20.0) | 12 (80.0) | 0.02 |
| Previous cardiac surgery | 12 (80.0) | 10 (66.6) | 22 (73.3) | 0.4 |
| Preoperative characteristics | ||||
| Oetiology of heart transplantation, number (%) | ||||
| Dilated cardiomyopathy | 10 (66.6) | 13 (86.6) | 23 (76.6) | 0.2 |
| Ischaemic cardiomyopathy | 4 (26.6) | 2 (13.3) | 6 (40.0) | 0.3 |
| Arrythmogenic right ventricular dysplasia | 1 (6.6) | 0 (0.0) | 1 (3.3) | 0.3 |
| Ejection fraction <30%, number (%) | 13 (86.6) | 12 (80.0) | 25 (83.3) | 0.6 |
| Paracorporeal ventricular assist device, number (%) | 8 (53.3) | 10 (66.6) | 18 (60.0) | 0.45 |
| Intraoperative characteristics | ||||
| Aortic cross-clamping time (min) | 70 ± 2.5 | 80 ± 6.6 | 70 ± 4.9 | 0.7 |
| Cardiopulmonary bypass duration (min) | 126 ± 17.3 | 109 ± 18.3 | 118 ± 19.3 | 0.01 |
| Transfusion requirement, unit (median IQR) | 6.5 (4.5, 10.0) | 4.0 (2.0, 6.0) | 4.0 (2.5, 8) | 0.05 |
| Postoperative characteristics | ||||
| eGFR before intervention (ml/min/1.73 m2) | 50 ± 7.2 | 52 ± 7.0 | 51 ± 7.1 | 0.3 |
| Serum creatinine before intervention (mg/dl) | 1.5 ± 0.3 | 1.1 ± 0.3 | 1.4 ± 0.4 | 0.2 |
| Acute tubular necrosis, number (%) | 7 (46.7) | 2 (13.3) | 9 (30.0) | 0.04 |
| Intervention duration (h) | 37 ± 22.5 | 48 | 43 ± 14.7 | 0.7 |
| Time to discharge (days) | 21 ± 21.0 | 19.6 ± 11.0 | 20 ± 16.5 | 0.8 |
| Heart transplant to discharge (days) | 15.2 ± 15.5 | 14.5 ± 9.8 | 14.9 ± 12.4 | 0.8 |
| Variables . | CRRT group (n = 15) . | Furosemide group (n = 15) . | Total (n = 30) . | P . |
|---|---|---|---|---|
| Age (years) | 37 ± 12.7 | 37 ± 12.4 | 37 ± 12.4 | 0.8 |
| Gender, number (%) | ||||
| Male | 9 (30.0) | 9 (30.0) | 18 (60.0) | 1 |
| Female | 6 (20.0) | 6 (20.0) | 12 (40.0) | 1 |
| Height (m) | 1.68 ± 10 | 1.69 ± 8.1 | 168 ± 8.9 | 0.7 |
| Weight (kg) | 65 ± 12.8 | 65 ± 11.8 | 65 ± 12.1 | 0.9 |
| Body mass index (kg/m2)a | 23 ± 3.8 | 23 ± 4.4 | 23 ± 4.0 | 0.9 |
| Comorbid features, number (%) | ||||
| Diabetes mellitus | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Myocardial infarction | 2 (13.3) | 2 (13.3) | 4 (13.3) | 1 |
| Hypertension | 1 (6.6) | 1 (6.6) | 2 (6.6) | 1 |
| Stroke | 2 (13.3) | 1 (6.6) | 3 (10.0) | 0.5 |
| Arteriosclerotic vascular disease | 9 (60.0) | 3 (20.0) | 12 (80.0) | 0.02 |
| Previous cardiac surgery | 12 (80.0) | 10 (66.6) | 22 (73.3) | 0.4 |
| Preoperative characteristics | ||||
| Oetiology of heart transplantation, number (%) | ||||
| Dilated cardiomyopathy | 10 (66.6) | 13 (86.6) | 23 (76.6) | 0.2 |
| Ischaemic cardiomyopathy | 4 (26.6) | 2 (13.3) | 6 (40.0) | 0.3 |
| Arrythmogenic right ventricular dysplasia | 1 (6.6) | 0 (0.0) | 1 (3.3) | 0.3 |
| Ejection fraction <30%, number (%) | 13 (86.6) | 12 (80.0) | 25 (83.3) | 0.6 |
| Paracorporeal ventricular assist device, number (%) | 8 (53.3) | 10 (66.6) | 18 (60.0) | 0.45 |
| Intraoperative characteristics | ||||
| Aortic cross-clamping time (min) | 70 ± 2.5 | 80 ± 6.6 | 70 ± 4.9 | 0.7 |
| Cardiopulmonary bypass duration (min) | 126 ± 17.3 | 109 ± 18.3 | 118 ± 19.3 | 0.01 |
| Transfusion requirement, unit (median IQR) | 6.5 (4.5, 10.0) | 4.0 (2.0, 6.0) | 4.0 (2.5, 8) | 0.05 |
| Postoperative characteristics | ||||
| eGFR before intervention (ml/min/1.73 m2) | 50 ± 7.2 | 52 ± 7.0 | 51 ± 7.1 | 0.3 |
| Serum creatinine before intervention (mg/dl) | 1.5 ± 0.3 | 1.1 ± 0.3 | 1.4 ± 0.4 | 0.2 |
| Acute tubular necrosis, number (%) | 7 (46.7) | 2 (13.3) | 9 (30.0) | 0.04 |
| Intervention duration (h) | 37 ± 22.5 | 48 | 43 ± 14.7 | 0.7 |
| Time to discharge (days) | 21 ± 21.0 | 19.6 ± 11.0 | 20 ± 16.5 | 0.8 |
| Heart transplant to discharge (days) | 15.2 ± 15.5 | 14.5 ± 9.8 | 14.9 ± 12.4 | 0.8 |
Plus–minus values are means ± SD. P values for continuous and categorical data variables were calculated with Student's t-test and chi-square test, respectively.
aThe body mass index is the weight in kilograms divided by the square of the height in metres.
CRRT: continuous renal replacement therapy; IQR: interquartile range; eGFR: estimated glomerular filtration rate.
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