| Genetic Alteration . | Targeted Agent . | Tumor Type . | # of Patients . |
|---|---|---|---|
| PIK3CA sub | mTOR inhibitor | Infiltrative astrocytoma | 3 |
| hypermutation | PD-1 inhibitor | Glioblastoma | 3 |
| PDGFRA amp or sub | dasatinib | Glioblastoma | 3 |
| KIAA1549-BRAF fusion | MEK inhibitor | Pilocytic astrocytoma | 2 |
| PTCH1 inactivation | SMO inhibitor | Medulloblastoma, nodular/desmoplastic | 2 |
| FGFR1 sub or kinase domain dup | kinase inhibitor | Low-grade glioma | 2 |
| H3F3A p.K27M | panobinostat | Diffuse midline glioma | 2 |
| AKT3 amp | mTOR inhibitor | Glioblastoma | 1 |
| MAP2K1 exon 2 small in-frame del | MEK inhibitor | Low-grade astrocytic neoplasm | 1 |
| ATG7-RAF1 fusion | MEK inhibitor | Pleomorphic xanthoastrocytoma | 1 |
| CDK4 amp | palbociclib | Glioblastoma | 1 |
| SMARCB1 del | EZH2 inhibitor | Chordoma | 1 |
| PALB2 inactivation | PARP inhibitor | Medulloblastoma | 1 |
| Genetic Alteration . | Targeted Agent . | Tumor Type . | # of Patients . |
|---|---|---|---|
| PIK3CA sub | mTOR inhibitor | Infiltrative astrocytoma | 3 |
| hypermutation | PD-1 inhibitor | Glioblastoma | 3 |
| PDGFRA amp or sub | dasatinib | Glioblastoma | 3 |
| KIAA1549-BRAF fusion | MEK inhibitor | Pilocytic astrocytoma | 2 |
| PTCH1 inactivation | SMO inhibitor | Medulloblastoma, nodular/desmoplastic | 2 |
| FGFR1 sub or kinase domain dup | kinase inhibitor | Low-grade glioma | 2 |
| H3F3A p.K27M | panobinostat | Diffuse midline glioma | 2 |
| AKT3 amp | mTOR inhibitor | Glioblastoma | 1 |
| MAP2K1 exon 2 small in-frame del | MEK inhibitor | Low-grade astrocytic neoplasm | 1 |
| ATG7-RAF1 fusion | MEK inhibitor | Pleomorphic xanthoastrocytoma | 1 |
| CDK4 amp | palbociclib | Glioblastoma | 1 |
| SMARCB1 del | EZH2 inhibitor | Chordoma | 1 |
| PALB2 inactivation | PARP inhibitor | Medulloblastoma | 1 |
Abbreviations: sub, missense mutation; amp, amplification; dup, duplication; del, deletion; EZH2, enhancer of zeste homolog 2.
| Genetic Alteration . | Targeted Agent . | Tumor Type . | # of Patients . |
|---|---|---|---|
| PIK3CA sub | mTOR inhibitor | Infiltrative astrocytoma | 3 |
| hypermutation | PD-1 inhibitor | Glioblastoma | 3 |
| PDGFRA amp or sub | dasatinib | Glioblastoma | 3 |
| KIAA1549-BRAF fusion | MEK inhibitor | Pilocytic astrocytoma | 2 |
| PTCH1 inactivation | SMO inhibitor | Medulloblastoma, nodular/desmoplastic | 2 |
| FGFR1 sub or kinase domain dup | kinase inhibitor | Low-grade glioma | 2 |
| H3F3A p.K27M | panobinostat | Diffuse midline glioma | 2 |
| AKT3 amp | mTOR inhibitor | Glioblastoma | 1 |
| MAP2K1 exon 2 small in-frame del | MEK inhibitor | Low-grade astrocytic neoplasm | 1 |
| ATG7-RAF1 fusion | MEK inhibitor | Pleomorphic xanthoastrocytoma | 1 |
| CDK4 amp | palbociclib | Glioblastoma | 1 |
| SMARCB1 del | EZH2 inhibitor | Chordoma | 1 |
| PALB2 inactivation | PARP inhibitor | Medulloblastoma | 1 |
| Genetic Alteration . | Targeted Agent . | Tumor Type . | # of Patients . |
|---|---|---|---|
| PIK3CA sub | mTOR inhibitor | Infiltrative astrocytoma | 3 |
| hypermutation | PD-1 inhibitor | Glioblastoma | 3 |
| PDGFRA amp or sub | dasatinib | Glioblastoma | 3 |
| KIAA1549-BRAF fusion | MEK inhibitor | Pilocytic astrocytoma | 2 |
| PTCH1 inactivation | SMO inhibitor | Medulloblastoma, nodular/desmoplastic | 2 |
| FGFR1 sub or kinase domain dup | kinase inhibitor | Low-grade glioma | 2 |
| H3F3A p.K27M | panobinostat | Diffuse midline glioma | 2 |
| AKT3 amp | mTOR inhibitor | Glioblastoma | 1 |
| MAP2K1 exon 2 small in-frame del | MEK inhibitor | Low-grade astrocytic neoplasm | 1 |
| ATG7-RAF1 fusion | MEK inhibitor | Pleomorphic xanthoastrocytoma | 1 |
| CDK4 amp | palbociclib | Glioblastoma | 1 |
| SMARCB1 del | EZH2 inhibitor | Chordoma | 1 |
| PALB2 inactivation | PARP inhibitor | Medulloblastoma | 1 |
Abbreviations: sub, missense mutation; amp, amplification; dup, duplication; del, deletion; EZH2, enhancer of zeste homolog 2.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
