Table 1 Open in new tab Initial and...

Neuroimaging Characteristics	Baseline	Relapse	Initial- Recurrence Comparison
T1 without enhancement
Hypointensity	46	73.0
Normointensity	13	20.6
Hyperintensity	4	6.4
Number of lesion(s) (range)	1 (1–7)	1 (1–6)	.534
Single	44	55.7	24	53.3
2	9	24.1	11	24.4
3 of more	13	20.2	10	22.3
Lateralization					.868
Right	26	32.9	11	24.4
Left	12	15.2	9	20
Bilateral	35	44.3	23	51.1
Median	6	7.6	2	4.4
Location					.692
Non-deep (superficial)	11	13.9	34	75.6
Deep (corpus callosum, basal ganglia, brainstem and/or cerebellum)	56	70.9	4	8.9
Both	12	15.2	7	15.6
Infratentorial lesions (brainstem and/or cerebellum)	14	17.7
Median T1 diameter, cm, median (range)	4 (0–16.4)	4.9 (1–16.5)	.951
Median T1 product, cm², median (range)	10.06 (0–39.19)	10 (0.8–49.14)	.128
Median T1 volume, cm³, median (range)	11.4 (0–96.2)	8.0 (0.2–123.5)	.137
Enhancement type					.247
Homogeneous	65	87.8	36	80
Heterogeneous	9	12.2	9	20
Meningeal enhancement	18	23.4	13	29.5	.382
Local	11	61.1	7	53.8
Diffuse	7	38.9	6	46.2
“Distant” FLAIR	18	23.7
Median FLAIR Diameter, mm, median (range)	83.5 (20–290)	90 (10-10-237)	.266
Median FLAIR product, mm², median (range)	4605 (320–12700)	3853.5 (100–10125)	.021
Median FLAIR Volume, cm³, median (range)	94.8 (2.7–447.7)	45.5 (0.4–300.4)	.015
FLAIR type of enhancing lesion					.649
Hypointensity	14	19.2	8	19.0
Normointensity	23	31.5	10	23.8
Hyperintensity	36	49.3	24	57.1

Neuroimaging Characteristics

Baseline

Relapse

Initial- Recurrence Comparison

T1 without enhancement

Hypointensity

73.0

Normointensity

20.6

Hyperintensity

6.4

Number of lesion(s) (range)

1 (1–7)

1 (1–6)

.534

Single

55.7

53.3

24.1

24.4

3 of more

20.2

22.3

Lateralization

.868

Right

32.9

24.4

Left

15.2

Bilateral

44.3

51.1

Median

7.6

4.4

Location

.692

Non-deep (superficial)

13.9

75.6

Deep (corpus callosum, basal ganglia, brainstem and/or cerebellum)

70.9

8.9

Both

15.2

15.6

Infratentorial lesions (brainstem and/or cerebellum)

17.7

Median T1 diameter, cm, median (range)

4 (0–16.4)

4.9 (1–16.5)

.951

Median T1 product, cm², median (range)

10.06 (0–39.19)

10 (0.8–49.14)

.128

Median T1 volume, cm³, median (range)

11.4 (0–96.2)

8.0 (0.2–123.5)

.137

Enhancement type

.247

Homogeneous

87.8

Heterogeneous

12.2

Meningeal enhancement

23.4

29.5

.382

Local

61.1

53.8

Diffuse

38.9

46.2

“Distant” FLAIR

23.7

Median FLAIR Diameter, mm, median (range)

83.5 (20–290)

90 (10-10-237)

.266

Median FLAIR product, mm², median (range)

4605 (320–12700)

3853.5 (100–10125)

.021

Median FLAIR Volume, cm³, median (range)

94.8 (2.7–447.7)

45.5 (0.4–300.4)

.015

FLAIR type of enhancing lesion

.649

Hypointensity

19.2

19.0

Normointensity

31.5

23.8

Hyperintensity

49.3

57.1

Neuroimaging Characteristics	Baseline	Relapse	Initial- Recurrence Comparison
T1 without enhancement
Hypointensity	46	73.0
Normointensity	13	20.6
Hyperintensity	4	6.4
Number of lesion(s) (range)	1 (1–7)	1 (1–6)	.534
Single	44	55.7	24	53.3
2	9	24.1	11	24.4
3 of more	13	20.2	10	22.3
Lateralization					.868
Right	26	32.9	11	24.4
Left	12	15.2	9	20
Bilateral	35	44.3	23	51.1
Median	6	7.6	2	4.4
Location					.692
Non-deep (superficial)	11	13.9	34	75.6
Deep (corpus callosum, basal ganglia, brainstem and/or cerebellum)	56	70.9	4	8.9
Both	12	15.2	7	15.6
Infratentorial lesions (brainstem and/or cerebellum)	14	17.7
Median T1 diameter, cm, median (range)	4 (0–16.4)	4.9 (1–16.5)	.951
Median T1 product, cm², median (range)	10.06 (0–39.19)	10 (0.8–49.14)	.128
Median T1 volume, cm³, median (range)	11.4 (0–96.2)	8.0 (0.2–123.5)	.137
Enhancement type					.247
Homogeneous	65	87.8	36	80
Heterogeneous	9	12.2	9	20
Meningeal enhancement	18	23.4	13	29.5	.382
Local	11	61.1	7	53.8
Diffuse	7	38.9	6	46.2
“Distant” FLAIR	18	23.7
Median FLAIR Diameter, mm, median (range)	83.5 (20–290)	90 (10-10-237)	.266
Median FLAIR product, mm², median (range)	4605 (320–12700)	3853.5 (100–10125)	.021
Median FLAIR Volume, cm³, median (range)	94.8 (2.7–447.7)	45.5 (0.4–300.4)	.015
FLAIR type of enhancing lesion					.649
Hypointensity	14	19.2	8	19.0
Normointensity	23	31.5	10	23.8
Hyperintensity	36	49.3	24	57.1

Table 1

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Initial and recurrent MRI characteristics

Neuroimaging Characteristics	Baseline		Relapse		Initial- Recurrence Comparison
	N	%	N	%	P
T1 without enhancement
Hypointensity	46	73.0
Normointensity	13	20.6
Hyperintensity	4	6.4
Number of lesion(s) (range)	1 (1–7)		1 (1–6)		.534
Single	44	55.7	24	53.3
2	9	24.1	11	24.4
3 of more	13	20.2	10	22.3
Lateralization					.868
Right	26	32.9	11	24.4
Left	12	15.2	9	20
Bilateral	35	44.3	23	51.1
Median	6	7.6	2	4.4
Location					.692
Non-deep (superficial)	11	13.9	34	75.6
Deep (corpus callosum, basal ganglia, brainstem and/or cerebellum)	56	70.9	4	8.9
Both	12	15.2	7	15.6
Infratentorial lesions (brainstem and/or cerebellum)	14	17.7
Median T1 diameter, cm, median (range)	4 (0–16.4)		4.9 (1–16.5)		.951
Median T1 product, cm², median (range)	10.06 (0–39.19)		10 (0.8–49.14)		.128
Median T1 volume, cm³, median (range)	11.4 (0–96.2)		8.0 (0.2–123.5)		.137
Enhancement type					.247
Homogeneous	65	87.8	36	80
Heterogeneous	9	12.2	9	20
Meningeal enhancement	18	23.4	13	29.5	.382
Local	11	61.1	7	53.8
Diffuse	7	38.9	6	46.2
“Distant” FLAIR	18	23.7
Median FLAIR Diameter, mm, median (range)	83.5 (20–290)		90 (10-10-237)		.266
Median FLAIR product, mm², median (range)	4605 (320–12700)		3853.5 (100–10125)		.021
Median FLAIR Volume, cm³, median (range)	94.8 (2.7–447.7)		45.5 (0.4–300.4)		.015
FLAIR type of enhancing lesion					.649
Hypointensity	14	19.2	8	19.0
Normointensity	23	31.5	10	23.8
Hyperintensity	36	49.3	24	57.1

Neuroimaging Characteristics	Baseline		Relapse		Initial- Recurrence Comparison
	N	%	N	%	P
T1 without enhancement
Hypointensity	46	73.0
Normointensity	13	20.6
Hyperintensity	4	6.4
Number of lesion(s) (range)	1 (1–7)		1 (1–6)		.534
Single	44	55.7	24	53.3
2	9	24.1	11	24.4
3 of more	13	20.2	10	22.3
Lateralization					.868
Right	26	32.9	11	24.4
Left	12	15.2	9	20
Bilateral	35	44.3	23	51.1
Median	6	7.6	2	4.4
Location					.692
Non-deep (superficial)	11	13.9	34	75.6
Deep (corpus callosum, basal ganglia, brainstem and/or cerebellum)	56	70.9	4	8.9
Both	12	15.2	7	15.6
Infratentorial lesions (brainstem and/or cerebellum)	14	17.7
Median T1 diameter, cm, median (range)	4 (0–16.4)		4.9 (1–16.5)		.951
Median T1 product, cm², median (range)	10.06 (0–39.19)		10 (0.8–49.14)		.128
Median T1 volume, cm³, median (range)	11.4 (0–96.2)		8.0 (0.2–123.5)		.137
Enhancement type					.247
Homogeneous	65	87.8	36	80
Heterogeneous	9	12.2	9	20
Meningeal enhancement	18	23.4	13	29.5	.382
Local	11	61.1	7	53.8
Diffuse	7	38.9	6	46.2
“Distant” FLAIR	18	23.7
Median FLAIR Diameter, mm, median (range)	83.5 (20–290)		90 (10-10-237)		.266
Median FLAIR product, mm², median (range)	4605 (320–12700)		3853.5 (100–10125)		.021
Median FLAIR Volume, cm³, median (range)	94.8 (2.7–447.7)		45.5 (0.4–300.4)		.015
FLAIR type of enhancing lesion					.649
Hypointensity	14	19.2	8	19.0
Normointensity	23	31.5	10	23.8
Hyperintensity	36	49.3	24	57.1

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