Table 3. Open in new tab Results of Bone...

Parameters

Control Values (15)

OI Type I (19)

Age at biopsy, y

11–13.9

7.6 ± 3.8

Structural parameters

BV/TV, %

24.4 ± 4.3

—^a

17.98

4.46

11.0 ± 5.2

Tb.Th, μm

148 ± 23

93.43

141.64

53.94

105.0 ± 25

Tb.N, /mm

1.66 ± 0.22

—^a

1.27

0.83

1.3 ± 0.39

Ct.Wi, mm

0.90 ± 0.33^b

0.81^a

0.60

0.56

0.52 ± 0.20

Static parameters of bone formation

OV/BV, %

2.12 ± 1.0

4.18

1.97

4.73

5.2 ± 2.6

O.Th, µm

6.7 ± 1.7

4.55

7.94

3.43

5.5 ± 1.7

OS/BS, %

22.1 ± 7.8

54.22

17.23

38.08

48 ± 14

Ob.S/BS, %

6.7 ± 4.5

2.97

0.96

8.98

19.4 ± 9.5

Dynamic parameters of bone formation

MS/BS, %

11.07 ± 5.0

7.05

N/A

9.93

48 ± 16

MAR, µm/d

0.87 ± 0.09

0.92

N/A

0.77

0.73 ± 0.18

Aj.AR, µm/d

0.46 ± 0.10

0.12

N/A

0.20

0.35 ± 0.14

BFR/BS, µm/y

37.3 ± 16.7

23.77

N/A

27.75

77 ± 34

BFR/BV, %/y

49.9 ± 21.4

50.28

N/A

108.18

116 ± 62

Mlt, d

14.5 ± 3.00

37.88

N/A

17.18

16.5 (12.5–19.8)

Static parameters of bone resorption

ES/BS, %

14.9 ± 5.6

2.94

1.55

15.6 (13.7–21.8)

Oc.S/BS, %

1.14 ± 0.74

0.15

0.10

1.37 (1.05–1.70)

N.Oc/BS, /mm

0.29 ± 0.14

0.04

0.03

0.47 ± 0.29

Table 3.

Open in new tab

Results of Bone Histomorphometry

Parameters	Control Values (15)	P2	P4	P7	OI Type I (19)
Age at biopsy, y	11–13.9	12	12	13	7.6 ± 3.8
Structural parameters
BV/TV, %	24.4 ± 4.3	—^a	17.98	4.46	11.0 ± 5.2
Tb.Th, μm	148 ± 23	93.43	141.64	53.94	105.0 ± 25
Tb.N, /mm	1.66 ± 0.22	—^a	1.27	0.83	1.3 ± 0.39
Ct.Wi, mm	0.90 ± 0.33^b	0.81^a	0.60	0.56	0.52 ± 0.20
Static parameters of bone formation
OV/BV, %	2.12 ± 1.0	4.18	1.97	4.73	5.2 ± 2.6
O.Th, µm	6.7 ± 1.7	4.55	7.94	3.43	5.5 ± 1.7
OS/BS, %	22.1 ± 7.8	54.22	17.23	38.08	48 ± 14
Ob.S/BS, %	6.7 ± 4.5	2.97	0.96	8.98	19.4 ± 9.5
Dynamic parameters of bone formation
MS/BS, %	11.07 ± 5.0	7.05	N/A	9.93	48 ± 16
MAR, µm/d	0.87 ± 0.09	0.92	N/A	0.77	0.73 ± 0.18
Aj.AR, µm/d	0.46 ± 0.10	0.12	N/A	0.20	0.35 ± 0.14
BFR/BS, µm/y	37.3 ± 16.7	23.77	N/A	27.75	77 ± 34
BFR/BV, %/y	49.9 ± 21.4	50.28	N/A	108.18	116 ± 62
Mlt, d	14.5 ± 3.00	37.88	N/A	17.18	16.5 (12.5–19.8)
Static parameters of bone resorption
ES/BS, %	14.9 ± 5.6	2.94	1.55	0	15.6 (13.7–21.8)
Oc.S/BS, %	1.14 ± 0.74	0.15	0.10	0	1.37 (1.05–1.70)
N.Oc/BS, /mm	0.29 ± 0.14	0.04	0.03	0	0.47 ± 0.29

Parameters	Control Values (15)	P2	P4	P7	OI Type I (19)
Age at biopsy, y	11–13.9	12	12	13	7.6 ± 3.8
Structural parameters
BV/TV, %	24.4 ± 4.3	—^a	17.98	4.46	11.0 ± 5.2
Tb.Th, μm	148 ± 23	93.43	141.64	53.94	105.0 ± 25
Tb.N, /mm	1.66 ± 0.22	—^a	1.27	0.83	1.3 ± 0.39
Ct.Wi, mm	0.90 ± 0.33^b	0.81^a	0.60	0.56	0.52 ± 0.20
Static parameters of bone formation
OV/BV, %	2.12 ± 1.0	4.18	1.97	4.73	5.2 ± 2.6
O.Th, µm	6.7 ± 1.7	4.55	7.94	3.43	5.5 ± 1.7
OS/BS, %	22.1 ± 7.8	54.22	17.23	38.08	48 ± 14
Ob.S/BS, %	6.7 ± 4.5	2.97	0.96	8.98	19.4 ± 9.5
Dynamic parameters of bone formation
MS/BS, %	11.07 ± 5.0	7.05	N/A	9.93	48 ± 16
MAR, µm/d	0.87 ± 0.09	0.92	N/A	0.77	0.73 ± 0.18
Aj.AR, µm/d	0.46 ± 0.10	0.12	N/A	0.20	0.35 ± 0.14
BFR/BS, µm/y	37.3 ± 16.7	23.77	N/A	27.75	77 ± 34
BFR/BV, %/y	49.9 ± 21.4	50.28	N/A	108.18	116 ± 62
Mlt, d	14.5 ± 3.00	37.88	N/A	17.18	16.5 (12.5–19.8)
Static parameters of bone resorption
ES/BS, %	14.9 ± 5.6	2.94	1.55	0	15.6 (13.7–21.8)
Oc.S/BS, %	1.14 ± 0.74	0.15	0.10	0	1.37 (1.05–1.70)
N.Oc/BS, /mm	0.29 ± 0.14	0.04	0.03	0	0.47 ± 0.29

For comparison, typical values for patients with OI type I are given (19). P4 did not receive tetracycline labeling.

Abbreviations: Aj.AR, adjusted apposition rate; BFR, bone formation rate; Ct.Wi, cortical thickness (width); MAR, mineral apposition rate; Mlt, mineralization lag time; MS, mineralizing surface; N/A, not applicable; N.Oc, osteoclast number; Ob.S, OB surface; Oc.S, osteoclast surface; OS, osteoid surface; O.Th, osteoid thickness; OV, osteoid volume; Tb.N, trabecular number; Tb.Th, trabecular thickness.

Sample contained only one cortical plate. Therefore, BV/TV and Tb.N could not be assessed.

Mean value from two cortical plates.

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