Cause of Central Diabetes Insipidus in Those Patients With Initially Idiopathic CDI, by Initial Brain MRI Result (n = 22)
| Diagnosis . | Initial MRI Findings . | Follow-Up to Diagnosis or End of Analysis . | Remarks . |
|---|---|---|---|
| Initial MRI with increased stalk thickness (n = 10)a | |||
| LCH (n = 3) | Infundibular thickening of 5.0–5.9 mm | 0.5–2.3 y (mean 1.5) | Biopsy of pituitary stalk (n = 1), lumbar spine (n = 1), and skin (n = 1) |
| Germinoma (n = 1) | Infundibular thickening of 4.1 mm | 1.8 y | Germinoma 1.8 y after CDI diagnosis |
| Idiopathic (n = 6) | Infundibular thickening of 3.5–5.1 mm | 1.3–13.5 y (mean 5.8) | Stalk thickening resolved or decreased in three of six patients |
| Initial MRI with normal stalk thickness (n = 12)a | |||
| Idiopathic (n = 12) | PPBS present (n = 4), absent (n = 8) | 0.6–15.3 y (mean 6.5) | |
| Diagnosis . | Initial MRI Findings . | Follow-Up to Diagnosis or End of Analysis . | Remarks . |
|---|---|---|---|
| Initial MRI with increased stalk thickness (n = 10)a | |||
| LCH (n = 3) | Infundibular thickening of 5.0–5.9 mm | 0.5–2.3 y (mean 1.5) | Biopsy of pituitary stalk (n = 1), lumbar spine (n = 1), and skin (n = 1) |
| Germinoma (n = 1) | Infundibular thickening of 4.1 mm | 1.8 y | Germinoma 1.8 y after CDI diagnosis |
| Idiopathic (n = 6) | Infundibular thickening of 3.5–5.1 mm | 1.3–13.5 y (mean 5.8) | Stalk thickening resolved or decreased in three of six patients |
| Initial MRI with normal stalk thickness (n = 12)a | |||
| Idiopathic (n = 12) | PPBS present (n = 4), absent (n = 8) | 0.6–15.3 y (mean 6.5) | |
Abbreviations: CDI, central diabetes insipidus; PPBS, posterior pituitary bright spot.
P = .03 for association between initial stalk thickness and having an underlying diagnosis identified.
Cause of Central Diabetes Insipidus in Those Patients With Initially Idiopathic CDI, by Initial Brain MRI Result (n = 22)
| Diagnosis . | Initial MRI Findings . | Follow-Up to Diagnosis or End of Analysis . | Remarks . |
|---|---|---|---|
| Initial MRI with increased stalk thickness (n = 10)a | |||
| LCH (n = 3) | Infundibular thickening of 5.0–5.9 mm | 0.5–2.3 y (mean 1.5) | Biopsy of pituitary stalk (n = 1), lumbar spine (n = 1), and skin (n = 1) |
| Germinoma (n = 1) | Infundibular thickening of 4.1 mm | 1.8 y | Germinoma 1.8 y after CDI diagnosis |
| Idiopathic (n = 6) | Infundibular thickening of 3.5–5.1 mm | 1.3–13.5 y (mean 5.8) | Stalk thickening resolved or decreased in three of six patients |
| Initial MRI with normal stalk thickness (n = 12)a | |||
| Idiopathic (n = 12) | PPBS present (n = 4), absent (n = 8) | 0.6–15.3 y (mean 6.5) | |
| Diagnosis . | Initial MRI Findings . | Follow-Up to Diagnosis or End of Analysis . | Remarks . |
|---|---|---|---|
| Initial MRI with increased stalk thickness (n = 10)a | |||
| LCH (n = 3) | Infundibular thickening of 5.0–5.9 mm | 0.5–2.3 y (mean 1.5) | Biopsy of pituitary stalk (n = 1), lumbar spine (n = 1), and skin (n = 1) |
| Germinoma (n = 1) | Infundibular thickening of 4.1 mm | 1.8 y | Germinoma 1.8 y after CDI diagnosis |
| Idiopathic (n = 6) | Infundibular thickening of 3.5–5.1 mm | 1.3–13.5 y (mean 5.8) | Stalk thickening resolved or decreased in three of six patients |
| Initial MRI with normal stalk thickness (n = 12)a | |||
| Idiopathic (n = 12) | PPBS present (n = 4), absent (n = 8) | 0.6–15.3 y (mean 6.5) | |
Abbreviations: CDI, central diabetes insipidus; PPBS, posterior pituitary bright spot.
P = .03 for association between initial stalk thickness and having an underlying diagnosis identified.
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