Multivariable Cox Model: Measured HRs and 95% CIs of aDCSI for Dementia at the Onset of Diabetes, Each Year of Follow-Up and the End Point
| Year . | n . | Adjusted HR (95% CI)a . | |||||
|---|---|---|---|---|---|---|---|
| aDCSI = 0 . | aDCSI = 1 . | aDCSI = 2 . | aDCSI = 3 . | aDCSI >3 . | P for Trend . | ||
| 0 | 431 178 | 1.00 | 0.98 (0.94–1.02) | 1.12 (1.08–1.16) | 1.26 (1.19–1.33) | 1.42 (1.35–1.50) | <.001 |
| 1 | 387 918 | 1.00 | 1.09 (1.05–1.13) | 1.35 (1.30–1.40) | 1.53 (1.46–1.61) | 1.80 (1.71–1.88) | <.001 |
| 2 | 350 120 | 1.00 | 1.11 (1.07–1.16) | 1.34 (1.28–1.40) | 1.58 (1.50–1.66) | 1.84 (1.76–1.94) | <.001 |
| 3 | 312 379 | 1.00 | 1.12 (1.06–1.17) | 1.34 (1.28–1.41) | 1.55 (1.47–1.64) | 1.88 (1.78–1.98) | <.001 |
| 4 | 274 426 | 1.00 | 1.15 (1.09–1.22) | 1.34 (1.27–1.42) | 1.57 (1.48–1.67) | 1.91 (1.80–2.02) | <.001 |
| 5 | 237 480 | 1.00 | 1.14 (1.07–1.22) | 1.34 (1.26–1.43) | 1.64 (1.53–1.75) | 1.94 (1.82–2.08) | <.001 |
| 6 | 200 801 | 1.00 | 1.12 (1.03–1.21) | 1.32 (1.23–1.43) | 1.67 (1.54–1.81) | 1.94 (1.80–2.09) | <.001 |
| 7 | 163 275 | 1.00 | 1.08 (0.98–1.19) | 1.36 (1.24–1.49) | 1.61 (1.46–1.78) | 1.93 (1.76–2.11) | <.001 |
| 8 | 127 991 | 1.00 | 1.06 (0.93–1.20) | 1.42 (1.26–1.60) | 1.77 (1.56–2.00) | 2.05 (1.82–2.31) | <.001 |
| 9 | 93 574 | 1.00 | 0.97 (0.82–1.16) | 1.32 (1.13–1.55) | 1.61 (1.36–1.90) | 1.90 (1.62–2.23) | <.001 |
| 10 | 60 975 | 1.00 | 1.05 (0.80–1.37) | 1.30 (1.01–1.67) | 1.74 (1.35–2.25) | 2.14 (1.68–2.72) | <.001 |
| End of follow-up | 431 178 | 1.00 | 1.04 (0.99–1.09) | 1.40 (1.34–1.46) | 1.54 (1.47–1.61) | 1.70 (1.63–1.78) | <.001 |
| Year . | n . | Adjusted HR (95% CI)a . | |||||
|---|---|---|---|---|---|---|---|
| aDCSI = 0 . | aDCSI = 1 . | aDCSI = 2 . | aDCSI = 3 . | aDCSI >3 . | P for Trend . | ||
| 0 | 431 178 | 1.00 | 0.98 (0.94–1.02) | 1.12 (1.08–1.16) | 1.26 (1.19–1.33) | 1.42 (1.35–1.50) | <.001 |
| 1 | 387 918 | 1.00 | 1.09 (1.05–1.13) | 1.35 (1.30–1.40) | 1.53 (1.46–1.61) | 1.80 (1.71–1.88) | <.001 |
| 2 | 350 120 | 1.00 | 1.11 (1.07–1.16) | 1.34 (1.28–1.40) | 1.58 (1.50–1.66) | 1.84 (1.76–1.94) | <.001 |
| 3 | 312 379 | 1.00 | 1.12 (1.06–1.17) | 1.34 (1.28–1.41) | 1.55 (1.47–1.64) | 1.88 (1.78–1.98) | <.001 |
| 4 | 274 426 | 1.00 | 1.15 (1.09–1.22) | 1.34 (1.27–1.42) | 1.57 (1.48–1.67) | 1.91 (1.80–2.02) | <.001 |
| 5 | 237 480 | 1.00 | 1.14 (1.07–1.22) | 1.34 (1.26–1.43) | 1.64 (1.53–1.75) | 1.94 (1.82–2.08) | <.001 |
| 6 | 200 801 | 1.00 | 1.12 (1.03–1.21) | 1.32 (1.23–1.43) | 1.67 (1.54–1.81) | 1.94 (1.80–2.09) | <.001 |
| 7 | 163 275 | 1.00 | 1.08 (0.98–1.19) | 1.36 (1.24–1.49) | 1.61 (1.46–1.78) | 1.93 (1.76–2.11) | <.001 |
| 8 | 127 991 | 1.00 | 1.06 (0.93–1.20) | 1.42 (1.26–1.60) | 1.77 (1.56–2.00) | 2.05 (1.82–2.31) | <.001 |
| 9 | 93 574 | 1.00 | 0.97 (0.82–1.16) | 1.32 (1.13–1.55) | 1.61 (1.36–1.90) | 1.90 (1.62–2.23) | <.001 |
| 10 | 60 975 | 1.00 | 1.05 (0.80–1.37) | 1.30 (1.01–1.67) | 1.74 (1.35–2.25) | 2.14 (1.68–2.72) | <.001 |
| End of follow-up | 431 178 | 1.00 | 1.04 (0.99–1.09) | 1.40 (1.34–1.46) | 1.54 (1.47–1.61) | 1.70 (1.63–1.78) | <.001 |
Adjusted for age, sex, income, urbanization, chronic kidney disease, COPD, depressive disorder antidiabetic drugs, and drug adherence.
Multivariable Cox Model: Measured HRs and 95% CIs of aDCSI for Dementia at the Onset of Diabetes, Each Year of Follow-Up and the End Point
| Year . | n . | Adjusted HR (95% CI)a . | |||||
|---|---|---|---|---|---|---|---|
| aDCSI = 0 . | aDCSI = 1 . | aDCSI = 2 . | aDCSI = 3 . | aDCSI >3 . | P for Trend . | ||
| 0 | 431 178 | 1.00 | 0.98 (0.94–1.02) | 1.12 (1.08–1.16) | 1.26 (1.19–1.33) | 1.42 (1.35–1.50) | <.001 |
| 1 | 387 918 | 1.00 | 1.09 (1.05–1.13) | 1.35 (1.30–1.40) | 1.53 (1.46–1.61) | 1.80 (1.71–1.88) | <.001 |
| 2 | 350 120 | 1.00 | 1.11 (1.07–1.16) | 1.34 (1.28–1.40) | 1.58 (1.50–1.66) | 1.84 (1.76–1.94) | <.001 |
| 3 | 312 379 | 1.00 | 1.12 (1.06–1.17) | 1.34 (1.28–1.41) | 1.55 (1.47–1.64) | 1.88 (1.78–1.98) | <.001 |
| 4 | 274 426 | 1.00 | 1.15 (1.09–1.22) | 1.34 (1.27–1.42) | 1.57 (1.48–1.67) | 1.91 (1.80–2.02) | <.001 |
| 5 | 237 480 | 1.00 | 1.14 (1.07–1.22) | 1.34 (1.26–1.43) | 1.64 (1.53–1.75) | 1.94 (1.82–2.08) | <.001 |
| 6 | 200 801 | 1.00 | 1.12 (1.03–1.21) | 1.32 (1.23–1.43) | 1.67 (1.54–1.81) | 1.94 (1.80–2.09) | <.001 |
| 7 | 163 275 | 1.00 | 1.08 (0.98–1.19) | 1.36 (1.24–1.49) | 1.61 (1.46–1.78) | 1.93 (1.76–2.11) | <.001 |
| 8 | 127 991 | 1.00 | 1.06 (0.93–1.20) | 1.42 (1.26–1.60) | 1.77 (1.56–2.00) | 2.05 (1.82–2.31) | <.001 |
| 9 | 93 574 | 1.00 | 0.97 (0.82–1.16) | 1.32 (1.13–1.55) | 1.61 (1.36–1.90) | 1.90 (1.62–2.23) | <.001 |
| 10 | 60 975 | 1.00 | 1.05 (0.80–1.37) | 1.30 (1.01–1.67) | 1.74 (1.35–2.25) | 2.14 (1.68–2.72) | <.001 |
| End of follow-up | 431 178 | 1.00 | 1.04 (0.99–1.09) | 1.40 (1.34–1.46) | 1.54 (1.47–1.61) | 1.70 (1.63–1.78) | <.001 |
| Year . | n . | Adjusted HR (95% CI)a . | |||||
|---|---|---|---|---|---|---|---|
| aDCSI = 0 . | aDCSI = 1 . | aDCSI = 2 . | aDCSI = 3 . | aDCSI >3 . | P for Trend . | ||
| 0 | 431 178 | 1.00 | 0.98 (0.94–1.02) | 1.12 (1.08–1.16) | 1.26 (1.19–1.33) | 1.42 (1.35–1.50) | <.001 |
| 1 | 387 918 | 1.00 | 1.09 (1.05–1.13) | 1.35 (1.30–1.40) | 1.53 (1.46–1.61) | 1.80 (1.71–1.88) | <.001 |
| 2 | 350 120 | 1.00 | 1.11 (1.07–1.16) | 1.34 (1.28–1.40) | 1.58 (1.50–1.66) | 1.84 (1.76–1.94) | <.001 |
| 3 | 312 379 | 1.00 | 1.12 (1.06–1.17) | 1.34 (1.28–1.41) | 1.55 (1.47–1.64) | 1.88 (1.78–1.98) | <.001 |
| 4 | 274 426 | 1.00 | 1.15 (1.09–1.22) | 1.34 (1.27–1.42) | 1.57 (1.48–1.67) | 1.91 (1.80–2.02) | <.001 |
| 5 | 237 480 | 1.00 | 1.14 (1.07–1.22) | 1.34 (1.26–1.43) | 1.64 (1.53–1.75) | 1.94 (1.82–2.08) | <.001 |
| 6 | 200 801 | 1.00 | 1.12 (1.03–1.21) | 1.32 (1.23–1.43) | 1.67 (1.54–1.81) | 1.94 (1.80–2.09) | <.001 |
| 7 | 163 275 | 1.00 | 1.08 (0.98–1.19) | 1.36 (1.24–1.49) | 1.61 (1.46–1.78) | 1.93 (1.76–2.11) | <.001 |
| 8 | 127 991 | 1.00 | 1.06 (0.93–1.20) | 1.42 (1.26–1.60) | 1.77 (1.56–2.00) | 2.05 (1.82–2.31) | <.001 |
| 9 | 93 574 | 1.00 | 0.97 (0.82–1.16) | 1.32 (1.13–1.55) | 1.61 (1.36–1.90) | 1.90 (1.62–2.23) | <.001 |
| 10 | 60 975 | 1.00 | 1.05 (0.80–1.37) | 1.30 (1.01–1.67) | 1.74 (1.35–2.25) | 2.14 (1.68–2.72) | <.001 |
| End of follow-up | 431 178 | 1.00 | 1.04 (0.99–1.09) | 1.40 (1.34–1.46) | 1.54 (1.47–1.61) | 1.70 (1.63–1.78) | <.001 |
Adjusted for age, sex, income, urbanization, chronic kidney disease, COPD, depressive disorder antidiabetic drugs, and drug adherence.
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