Table 2.
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Complications Among 16 HSD3B2 c.35G>A Homozygotes

ComplicationStandard Dose (n = 9)High Dose (n = 7)Fisher's Exact Test
n%n%P ValueOR95% CI
Adrenal insufficiency
    Adrenal crisis222457.301
    Hypoglycemia1a112a29.458
    Hyperkalemic acidosis444229.633
    Cautionary growth/failure to thrive444114.308
    Hypospadias2b224b57na
Sex steroid excess
    Advanced skeletal maturation00457.01924.41.03–581.1
    Hirsutism/acne00571.00541.81.68–1040
    TARTs00233na
    Polycystic ovary syndromec00229na
Iatrogenic complications
    Hypertension778343.302
    Obesity00571.00541.81.68–1040
    Cushing syndrome331571.310
    Delayed skeletal maturation1111141.000
ComplicationStandard Dose (n = 9)High Dose (n = 7)Fisher's Exact Test
n%n%P ValueOR95% CI
Adrenal insufficiency
    Adrenal crisis222457.301
    Hypoglycemia1a112a29.458
    Hyperkalemic acidosis444229.633
    Cautionary growth/failure to thrive444114.308
    Hypospadias2b224b57na
Sex steroid excess
    Advanced skeletal maturation00457.01924.41.03–581.1
    Hirsutism/acne00571.00541.81.68–1040
    TARTs00233na
    Polycystic ovary syndromec00229na
Iatrogenic complications
    Hypertension778343.302
    Obesity00571.00541.81.68–1040
    Cushing syndrome331571.310
    Delayed skeletal maturation1111141.000

Abbreviations: na, not applicable; OR, odds ratio; CI, confidence interval.

a

In two of three cases resulting in early morning seizure.

b

All males (n = 6) were born with hypospadias requiring surgical repair.

c

Among females of reproductive age.

Table 2.
Open in new tab

Complications Among 16 HSD3B2 c.35G>A Homozygotes

ComplicationStandard Dose (n = 9)High Dose (n = 7)Fisher's Exact Test
n%n%P ValueOR95% CI
Adrenal insufficiency
    Adrenal crisis222457.301
    Hypoglycemia1a112a29.458
    Hyperkalemic acidosis444229.633
    Cautionary growth/failure to thrive444114.308
    Hypospadias2b224b57na
Sex steroid excess
    Advanced skeletal maturation00457.01924.41.03–581.1
    Hirsutism/acne00571.00541.81.68–1040
    TARTs00233na
    Polycystic ovary syndromec00229na
Iatrogenic complications
    Hypertension778343.302
    Obesity00571.00541.81.68–1040
    Cushing syndrome331571.310
    Delayed skeletal maturation1111141.000
ComplicationStandard Dose (n = 9)High Dose (n = 7)Fisher's Exact Test
n%n%P ValueOR95% CI
Adrenal insufficiency
    Adrenal crisis222457.301
    Hypoglycemia1a112a29.458
    Hyperkalemic acidosis444229.633
    Cautionary growth/failure to thrive444114.308
    Hypospadias2b224b57na
Sex steroid excess
    Advanced skeletal maturation00457.01924.41.03–581.1
    Hirsutism/acne00571.00541.81.68–1040
    TARTs00233na
    Polycystic ovary syndromec00229na
Iatrogenic complications
    Hypertension778343.302
    Obesity00571.00541.81.68–1040
    Cushing syndrome331571.310
    Delayed skeletal maturation1111141.000

Abbreviations: na, not applicable; OR, odds ratio; CI, confidence interval.

a

In two of three cases resulting in early morning seizure.

b

All males (n = 6) were born with hypospadias requiring surgical repair.

c

Among females of reproductive age.

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