Summary of Uric Acid Transport Kinetics of URAT1 Constructs.
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Notes.—Affinities in Km and transport capacities in Tmax were obtained from saturation transport curves, and are the mean of three experiments. Red represents high affinity (tight binding) and high capacity, whereas blue represents low affinity (weak binding) and low capacity.
Statistical analysis is based on the unpaired, two-tailed test.
*P < 0.05,
**P < 0.01,
***P < 0.001,
****P < 0.0001 compared with human.
††P < 0.001 compared with An74.
‡‡P < 0.01 compared with An75.
Summary of Uric Acid Transport Kinetics of URAT1 Constructs.
|
|
Notes.—Affinities in Km and transport capacities in Tmax were obtained from saturation transport curves, and are the mean of three experiments. Red represents high affinity (tight binding) and high capacity, whereas blue represents low affinity (weak binding) and low capacity.
Statistical analysis is based on the unpaired, two-tailed test.
*P < 0.05,
**P < 0.01,
***P < 0.001,
****P < 0.0001 compared with human.
††P < 0.001 compared with An74.
‡‡P < 0.01 compared with An75.
