Table 1.
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Summary of relative IHC staining signals for eIF4A, eIF4E, and eIF4G in normal sciatic nerves, MPNSTs, and vestibular schwannomas. Tissue sections were processed by immunohistochemistry analysis as described in Materials and Methods. Quantification of immunostaining signal was performed by visual analysis on a 0 to 3+ scale (0 as negative, 0.5+ as weak positive, 1+ as moderate positive, 2+ as strong positive, and 3+ as very strong positive) based on the intensity and percentage of immunopositive cells and their subcellular compartmentalization

Tissue/TumorID No.eIF4AeIF4EeIF4G
Sciatic nerve10 (rare 0.5+)00
20 (occasional 0.5+)00
MPNSTM11 ∼ 2 +2 +3 +
M20 ∼ 0.5 +0 ∼ 1 +0 ∼ 1 +
M31 ∼ 2 +2 ∼ 3 +0 ∼ 1 +
M4Rare 1+ (mostly necrosis)0 (necrotic tissue)0 (necrotic tissue)
M51 +2 ∼ 3 +1 ∼ 2 +
M60 ∼ 0.5 +1 +3 +
M70.5 ∼ 1 +1 +0 ∼ 1 +
M80 (occasional 0.5+)00
M90 with patchy 1 +0.5 ∼ 1 +1 ∼ 3 +
M101+ with patchy 2 +1 ∼ 2 +3 +
M111 ∼ 2 +00 ∼ 0.5 +
M120 ∼ 1 +0 ∼ 1 +1 ∼ 2 +
M131 ∼ 3 +1 +3 +
M140 ∼ 0.5 +1 +3 +
M151 ∼ 2 +3 +1 +
M161 ∼ 2 +3+ with patchy 2 +3 +
M170.5 ∼ 1 +1+ with patchy 2 +Patchy 3 +
M180 ∼ 0.5 +0.5 ∼ 1 +1+ with patchy 2 +
M190 ∼ 0.5 +1 ∼ 1.5 +0 ∼ 0.5 +
Vestibular schwannomaVS10 with patchy 2 +0 ∼ 1 +1 +
VS22 +2 ∼ 3 +1 ∼ 2 +
VS32 ∼ 3 +2+ with patchy 3 +1 +
VS42 ∼ 3 +1+ with patchy 2 +1 +
VS51 +1 +1 +
VS61 ∼ 2 +3 +ND
VS72 ∼ 3 +3 +1 ∼ 2 +
VS81 +3 +1+ with patchy 2 +
VS91 +0.5 ∼ 1+2 +
VS103 +3 +1 ∼ 1.5 +
VS113 +3 +1 ∼ 2 +
VS123 +3 +0.5 ∼ 1 +
VS131+ with patchy 3 +3 +0.5 ∼ 1 +
VS141 ∼ 2 +1 +1 +
VS152 ∼ 3 +3 +2 +
VS161 ∼ 2 +2 ∼ 3 +2 +
VS173 +1 ∼ 2 +1 +
VS182 ∼ 3 +1 +0 with patchy 2 +
VS192 ∼ 3 +2+ with patchy 3 +0 with patchy 1 +
VS202 ∼ 3 +1 ∼ 2 +ND
Tissue/TumorID No.eIF4AeIF4EeIF4G
Sciatic nerve10 (rare 0.5+)00
20 (occasional 0.5+)00
MPNSTM11 ∼ 2 +2 +3 +
M20 ∼ 0.5 +0 ∼ 1 +0 ∼ 1 +
M31 ∼ 2 +2 ∼ 3 +0 ∼ 1 +
M4Rare 1+ (mostly necrosis)0 (necrotic tissue)0 (necrotic tissue)
M51 +2 ∼ 3 +1 ∼ 2 +
M60 ∼ 0.5 +1 +3 +
M70.5 ∼ 1 +1 +0 ∼ 1 +
M80 (occasional 0.5+)00
M90 with patchy 1 +0.5 ∼ 1 +1 ∼ 3 +
M101+ with patchy 2 +1 ∼ 2 +3 +
M111 ∼ 2 +00 ∼ 0.5 +
M120 ∼ 1 +0 ∼ 1 +1 ∼ 2 +
M131 ∼ 3 +1 +3 +
M140 ∼ 0.5 +1 +3 +
M151 ∼ 2 +3 +1 +
M161 ∼ 2 +3+ with patchy 2 +3 +
M170.5 ∼ 1 +1+ with patchy 2 +Patchy 3 +
M180 ∼ 0.5 +0.5 ∼ 1 +1+ with patchy 2 +
M190 ∼ 0.5 +1 ∼ 1.5 +0 ∼ 0.5 +
Vestibular schwannomaVS10 with patchy 2 +0 ∼ 1 +1 +
VS22 +2 ∼ 3 +1 ∼ 2 +
VS32 ∼ 3 +2+ with patchy 3 +1 +
VS42 ∼ 3 +1+ with patchy 2 +1 +
VS51 +1 +1 +
VS61 ∼ 2 +3 +ND
VS72 ∼ 3 +3 +1 ∼ 2 +
VS81 +3 +1+ with patchy 2 +
VS91 +0.5 ∼ 1+2 +
VS103 +3 +1 ∼ 1.5 +
VS113 +3 +1 ∼ 2 +
VS123 +3 +0.5 ∼ 1 +
VS131+ with patchy 3 +3 +0.5 ∼ 1 +
VS141 ∼ 2 +1 +1 +
VS152 ∼ 3 +3 +2 +
VS161 ∼ 2 +2 ∼ 3 +2 +
VS173 +1 ∼ 2 +1 +
VS182 ∼ 3 +1 +0 with patchy 2 +
VS192 ∼ 3 +2+ with patchy 3 +0 with patchy 1 +
VS202 ∼ 3 +1 ∼ 2 +ND
Table 1.
Open in new tab

Summary of relative IHC staining signals for eIF4A, eIF4E, and eIF4G in normal sciatic nerves, MPNSTs, and vestibular schwannomas. Tissue sections were processed by immunohistochemistry analysis as described in Materials and Methods. Quantification of immunostaining signal was performed by visual analysis on a 0 to 3+ scale (0 as negative, 0.5+ as weak positive, 1+ as moderate positive, 2+ as strong positive, and 3+ as very strong positive) based on the intensity and percentage of immunopositive cells and their subcellular compartmentalization

Tissue/TumorID No.eIF4AeIF4EeIF4G
Sciatic nerve10 (rare 0.5+)00
20 (occasional 0.5+)00
MPNSTM11 ∼ 2 +2 +3 +
M20 ∼ 0.5 +0 ∼ 1 +0 ∼ 1 +
M31 ∼ 2 +2 ∼ 3 +0 ∼ 1 +
M4Rare 1+ (mostly necrosis)0 (necrotic tissue)0 (necrotic tissue)
M51 +2 ∼ 3 +1 ∼ 2 +
M60 ∼ 0.5 +1 +3 +
M70.5 ∼ 1 +1 +0 ∼ 1 +
M80 (occasional 0.5+)00
M90 with patchy 1 +0.5 ∼ 1 +1 ∼ 3 +
M101+ with patchy 2 +1 ∼ 2 +3 +
M111 ∼ 2 +00 ∼ 0.5 +
M120 ∼ 1 +0 ∼ 1 +1 ∼ 2 +
M131 ∼ 3 +1 +3 +
M140 ∼ 0.5 +1 +3 +
M151 ∼ 2 +3 +1 +
M161 ∼ 2 +3+ with patchy 2 +3 +
M170.5 ∼ 1 +1+ with patchy 2 +Patchy 3 +
M180 ∼ 0.5 +0.5 ∼ 1 +1+ with patchy 2 +
M190 ∼ 0.5 +1 ∼ 1.5 +0 ∼ 0.5 +
Vestibular schwannomaVS10 with patchy 2 +0 ∼ 1 +1 +
VS22 +2 ∼ 3 +1 ∼ 2 +
VS32 ∼ 3 +2+ with patchy 3 +1 +
VS42 ∼ 3 +1+ with patchy 2 +1 +
VS51 +1 +1 +
VS61 ∼ 2 +3 +ND
VS72 ∼ 3 +3 +1 ∼ 2 +
VS81 +3 +1+ with patchy 2 +
VS91 +0.5 ∼ 1+2 +
VS103 +3 +1 ∼ 1.5 +
VS113 +3 +1 ∼ 2 +
VS123 +3 +0.5 ∼ 1 +
VS131+ with patchy 3 +3 +0.5 ∼ 1 +
VS141 ∼ 2 +1 +1 +
VS152 ∼ 3 +3 +2 +
VS161 ∼ 2 +2 ∼ 3 +2 +
VS173 +1 ∼ 2 +1 +
VS182 ∼ 3 +1 +0 with patchy 2 +
VS192 ∼ 3 +2+ with patchy 3 +0 with patchy 1 +
VS202 ∼ 3 +1 ∼ 2 +ND
Tissue/TumorID No.eIF4AeIF4EeIF4G
Sciatic nerve10 (rare 0.5+)00
20 (occasional 0.5+)00
MPNSTM11 ∼ 2 +2 +3 +
M20 ∼ 0.5 +0 ∼ 1 +0 ∼ 1 +
M31 ∼ 2 +2 ∼ 3 +0 ∼ 1 +
M4Rare 1+ (mostly necrosis)0 (necrotic tissue)0 (necrotic tissue)
M51 +2 ∼ 3 +1 ∼ 2 +
M60 ∼ 0.5 +1 +3 +
M70.5 ∼ 1 +1 +0 ∼ 1 +
M80 (occasional 0.5+)00
M90 with patchy 1 +0.5 ∼ 1 +1 ∼ 3 +
M101+ with patchy 2 +1 ∼ 2 +3 +
M111 ∼ 2 +00 ∼ 0.5 +
M120 ∼ 1 +0 ∼ 1 +1 ∼ 2 +
M131 ∼ 3 +1 +3 +
M140 ∼ 0.5 +1 +3 +
M151 ∼ 2 +3 +1 +
M161 ∼ 2 +3+ with patchy 2 +3 +
M170.5 ∼ 1 +1+ with patchy 2 +Patchy 3 +
M180 ∼ 0.5 +0.5 ∼ 1 +1+ with patchy 2 +
M190 ∼ 0.5 +1 ∼ 1.5 +0 ∼ 0.5 +
Vestibular schwannomaVS10 with patchy 2 +0 ∼ 1 +1 +
VS22 +2 ∼ 3 +1 ∼ 2 +
VS32 ∼ 3 +2+ with patchy 3 +1 +
VS42 ∼ 3 +1+ with patchy 2 +1 +
VS51 +1 +1 +
VS61 ∼ 2 +3 +ND
VS72 ∼ 3 +3 +1 ∼ 2 +
VS81 +3 +1+ with patchy 2 +
VS91 +0.5 ∼ 1+2 +
VS103 +3 +1 ∼ 1.5 +
VS113 +3 +1 ∼ 2 +
VS123 +3 +0.5 ∼ 1 +
VS131+ with patchy 3 +3 +0.5 ∼ 1 +
VS141 ∼ 2 +1 +1 +
VS152 ∼ 3 +3 +2 +
VS161 ∼ 2 +2 ∼ 3 +2 +
VS173 +1 ∼ 2 +1 +
VS182 ∼ 3 +1 +0 with patchy 2 +
VS192 ∼ 3 +2+ with patchy 3 +0 with patchy 1 +
VS202 ∼ 3 +1 ∼ 2 +ND
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