List of isolates with putative compensatory mutations that affect the properties of the bridge helix
| Rifampicin resistance mutation . | Secondary RNA polymerase mutation . | Organism . | Compensationa . | Reference . |
|---|---|---|---|---|
| rpoB Q513P | rpoB R633L | M. tuberculosis | ND | 49 |
| rpoB H526D | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB H526R | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB R529C | rpoB R637C | S. typhimurium | yes | 48 |
| rpoB R529C | rpoB H673Y | S. typhimurium | yes | 48 |
| rpoB R529C | rpoC L770P | S. typhimurium | yes | 48 |
| rpoB S531L | rpoB I603M | M. tuberculosis | ND | 49 |
| rpoB S531L | rpoB V615M | M. tuberculosis | yes | this study |
| Rifampicin resistance mutation . | Secondary RNA polymerase mutation . | Organism . | Compensationa . | Reference . |
|---|---|---|---|---|
| rpoB Q513P | rpoB R633L | M. tuberculosis | ND | 49 |
| rpoB H526D | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB H526R | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB R529C | rpoB R637C | S. typhimurium | yes | 48 |
| rpoB R529C | rpoB H673Y | S. typhimurium | yes | 48 |
| rpoB R529C | rpoC L770P | S. typhimurium | yes | 48 |
| rpoB S531L | rpoB I603M | M. tuberculosis | ND | 49 |
| rpoB S531L | rpoB V615M | M. tuberculosis | yes | this study |
ND, not determined.
aSecondary mutation experimentally shown to compensate the fitness cost caused by the rifampicin resistance mutation.
List of isolates with putative compensatory mutations that affect the properties of the bridge helix
| Rifampicin resistance mutation . | Secondary RNA polymerase mutation . | Organism . | Compensationa . | Reference . |
|---|---|---|---|---|
| rpoB Q513P | rpoB R633L | M. tuberculosis | ND | 49 |
| rpoB H526D | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB H526R | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB R529C | rpoB R637C | S. typhimurium | yes | 48 |
| rpoB R529C | rpoB H673Y | S. typhimurium | yes | 48 |
| rpoB R529C | rpoC L770P | S. typhimurium | yes | 48 |
| rpoB S531L | rpoB I603M | M. tuberculosis | ND | 49 |
| rpoB S531L | rpoB V615M | M. tuberculosis | yes | this study |
| Rifampicin resistance mutation . | Secondary RNA polymerase mutation . | Organism . | Compensationa . | Reference . |
|---|---|---|---|---|
| rpoB Q513P | rpoB R633L | M. tuberculosis | ND | 49 |
| rpoB H526D | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB H526R | rpoB D626E | M. tuberculosis | ND | 49 |
| rpoB R529C | rpoB R637C | S. typhimurium | yes | 48 |
| rpoB R529C | rpoB H673Y | S. typhimurium | yes | 48 |
| rpoB R529C | rpoC L770P | S. typhimurium | yes | 48 |
| rpoB S531L | rpoB I603M | M. tuberculosis | ND | 49 |
| rpoB S531L | rpoB V615M | M. tuberculosis | yes | this study |
ND, not determined.
aSecondary mutation experimentally shown to compensate the fitness cost caused by the rifampicin resistance mutation.
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