Table 5. Open in new tab Interactions...

Strain	Multiple of the MIC of conventional antibiotics	Combination effect, time in h
E. coli CTX-M-15	CTX 0.5×	synergy, 9 h	synergy, 6 h	indifference
AMK 0.25×	synergy, 9 h	synergy, 9 h	indifference
CIP 0.5×	synergy, 6 h	synergy, 6 h	indifference
K. pneumoniae KPC-2	CTX 0.25×	indifference	synergy, 24 h	synergy, 24 h
IPM 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
CIP 0.5×	indifference	indifference	synergy, 24 h
P. aeruginosa VIM-1	CAZ 0.5×	synergy, 6 h	synergy, 9 h	synergy, 24 h
IPM 0.125×	synergy, 6 h^a	synergy, 9 h	synergy, 24 h
AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 24 h
CIP 0.25×	indifference	indifference	synergy, 24 h
A. baumannii OXA-23	IPM 0.5×	ND	synergy, 3 h	synergy, 3 h
AMK 0.062×	ND	indifference	indifference
CIP 0.5×	ND	synergy, 6 h^a	synergy, 6 h

Strain	Multiple of the MIC of conventional antibiotics	Combination effect, time in h
E. coli CTX-M-15	CTX 0.5×	synergy, 9 h	synergy, 6 h	indifference
AMK 0.25×	synergy, 9 h	synergy, 9 h	indifference
CIP 0.5×	synergy, 6 h	synergy, 6 h	indifference
K. pneumoniae KPC-2	CTX 0.25×	indifference	synergy, 24 h	synergy, 24 h
IPM 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
CIP 0.5×	indifference	indifference	synergy, 24 h
P. aeruginosa VIM-1	CAZ 0.5×	synergy, 6 h	synergy, 9 h	synergy, 24 h
IPM 0.125×	synergy, 6 h^a	synergy, 9 h	synergy, 24 h
AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 24 h
CIP 0.25×	indifference	indifference	synergy, 24 h
A. baumannii OXA-23	IPM 0.5×	ND	synergy, 3 h	synergy, 3 h
AMK 0.062×	ND	indifference	indifference
CIP 0.5×	ND	synergy, 6 h^a	synergy, 6 h

Table 5.

Interactions between conventional antibiotics and LPC-058 at 0.25×, 0.5× and 1× MIC against E. coli producing CTX-M-15 ESBL and K. pneumoniae, P. aeruginosa and A. baumannii producing KPC-2, VIM-1 and OXA-23 carbapenemases, respectively

Strain	Multiple of the MIC of conventional antibiotics	Combination effect, time in h
		multiple of the MIC of LPC-058
		0.25×	0.5×	1×
E. coli CTX-M-15	CTX 0.5×	synergy, 9 h	synergy, 6 h	indifference
	AMK 0.25×	synergy, 9 h	synergy, 9 h	indifference
	CIP 0.5×	synergy, 6 h	synergy, 6 h	indifference
K. pneumoniae KPC-2	CTX 0.25×	indifference	synergy, 24 h	synergy, 24 h
	IPM 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
	AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
	CIP 0.5×	indifference	indifference	synergy, 24 h
P. aeruginosa VIM-1	CAZ 0.5×	synergy, 6 h	synergy, 9 h	synergy, 24 h
	IPM 0.125×	synergy, 6 h^a	synergy, 9 h	synergy, 24 h
	AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 24 h
	CIP 0.25×	indifference	indifference	synergy, 24 h
A. baumannii OXA-23	IPM 0.5×	ND	synergy, 3 h	synergy, 3 h
	AMK 0.062×	ND	indifference	indifference
	CIP 0.5×	ND	synergy, 6 h^a	synergy, 6 h

Strain	Multiple of the MIC of conventional antibiotics	Combination effect, time in h
		multiple of the MIC of LPC-058
		0.25×	0.5×	1×
E. coli CTX-M-15	CTX 0.5×	synergy, 9 h	synergy, 6 h	indifference
	AMK 0.25×	synergy, 9 h	synergy, 9 h	indifference
	CIP 0.5×	synergy, 6 h	synergy, 6 h	indifference
K. pneumoniae KPC-2	CTX 0.25×	indifference	synergy, 24 h	synergy, 24 h
	IPM 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
	AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 9 h
	CIP 0.5×	indifference	indifference	synergy, 24 h
P. aeruginosa VIM-1	CAZ 0.5×	synergy, 6 h	synergy, 9 h	synergy, 24 h
	IPM 0.125×	synergy, 6 h^a	synergy, 9 h	synergy, 24 h
	AMK 0.5×	synergy, 9 h	synergy, 9 h	synergy, 24 h
	CIP 0.25×	indifference	indifference	synergy, 24 h
A. baumannii OXA-23	IPM 0.5×	ND	synergy, 3 h	synergy, 3 h
	AMK 0.062×	ND	indifference	indifference
	CIP 0.5×	ND	synergy, 6 h^a	synergy, 6 h

CTX, cefotaxime; CAZ, ceftazidime; IPM, imipenem; AMK, amikacin; CIP, ciprofloxacin; ND, not determined.

^aBacterial regrowth at 24 h.

This Feature Is Available To Subscribers Only