Table 3.
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Activities of LpxC inhibitors as a function of the resistance phenotype in Enterobacteriaceae, P. aeruginosa and A. baumannii

Organism group (number tested)MIC (mg/L)LPC-058LPC-011LPC-087CHIR-090
Enterobacteriaceae non-MDR/XDR (196)MIC500.060.120.250.5
MIC900.120.250.51
range≤0.015–0.25≤0.015–1≤0.015–10.03–2
Enterobacteriaceae MDR or XDR (38a)MIC500.060.120.250.5
MIC900.250.512
range≤0.015–0.250.06–10.25–10.25–8
P. aeruginosa non-MDR/XDR (31)MIC500.250.522
MIC900.5144
range0.06–0.50.25–20.25–40.5–8
P. aeruginosa MDR or XDR (20b)MIC500.250.544
MIC900.5188
range0.12–0.50.25–11–82–8
A. baumannii non-MDR/XDR (6)MIC500.25≥641≥64
MIC900.5≥642≥64
range0.12–0.5≥640.5–2≥64
A. baumannii MDR or XDR (20c)MIC500.25≥641≥64
MIC901≥6432≥64
range0.12–4≥640.5 to ≥64≥64
Organism group (number tested)MIC (mg/L)LPC-058LPC-011LPC-087CHIR-090
Enterobacteriaceae non-MDR/XDR (196)MIC500.060.120.250.5
MIC900.120.250.51
range≤0.015–0.25≤0.015–1≤0.015–10.03–2
Enterobacteriaceae MDR or XDR (38a)MIC500.060.120.250.5
MIC900.250.512
range≤0.015–0.250.06–10.25–10.25–8
P. aeruginosa non-MDR/XDR (31)MIC500.250.522
MIC900.5144
range0.06–0.50.25–20.25–40.5–8
P. aeruginosa MDR or XDR (20b)MIC500.250.544
MIC900.5188
range0.12–0.50.25–11–82–8
A. baumannii non-MDR/XDR (6)MIC500.25≥641≥64
MIC900.5≥642≥64
range0.12–0.5≥640.5–2≥64
A. baumannii MDR or XDR (20c)MIC500.25≥641≥64
MIC901≥6432≥64
range0.12–4≥640.5 to ≥64≥64

aIncludes 17 ESBL-producing and 5 carbapenemase-producing strains [OXA-48 (n = 3), NDM (n = 1) and KPC (n = 1)].

bIncludes three ESBL-producing and five carbapenemase-producing strains [VIM (n = 4) and IMP (n = 1)].

cIncludes 1 ESBL-producing and 10 carbapenemase-producing strains [OXA-23 (n = 9) and OXA-40 (n = 1)].

Table 3.
Open in new tab

Activities of LpxC inhibitors as a function of the resistance phenotype in Enterobacteriaceae, P. aeruginosa and A. baumannii

Organism group (number tested)MIC (mg/L)LPC-058LPC-011LPC-087CHIR-090
Enterobacteriaceae non-MDR/XDR (196)MIC500.060.120.250.5
MIC900.120.250.51
range≤0.015–0.25≤0.015–1≤0.015–10.03–2
Enterobacteriaceae MDR or XDR (38a)MIC500.060.120.250.5
MIC900.250.512
range≤0.015–0.250.06–10.25–10.25–8
P. aeruginosa non-MDR/XDR (31)MIC500.250.522
MIC900.5144
range0.06–0.50.25–20.25–40.5–8
P. aeruginosa MDR or XDR (20b)MIC500.250.544
MIC900.5188
range0.12–0.50.25–11–82–8
A. baumannii non-MDR/XDR (6)MIC500.25≥641≥64
MIC900.5≥642≥64
range0.12–0.5≥640.5–2≥64
A. baumannii MDR or XDR (20c)MIC500.25≥641≥64
MIC901≥6432≥64
range0.12–4≥640.5 to ≥64≥64
Organism group (number tested)MIC (mg/L)LPC-058LPC-011LPC-087CHIR-090
Enterobacteriaceae non-MDR/XDR (196)MIC500.060.120.250.5
MIC900.120.250.51
range≤0.015–0.25≤0.015–1≤0.015–10.03–2
Enterobacteriaceae MDR or XDR (38a)MIC500.060.120.250.5
MIC900.250.512
range≤0.015–0.250.06–10.25–10.25–8
P. aeruginosa non-MDR/XDR (31)MIC500.250.522
MIC900.5144
range0.06–0.50.25–20.25–40.5–8
P. aeruginosa MDR or XDR (20b)MIC500.250.544
MIC900.5188
range0.12–0.50.25–11–82–8
A. baumannii non-MDR/XDR (6)MIC500.25≥641≥64
MIC900.5≥642≥64
range0.12–0.5≥640.5–2≥64
A. baumannii MDR or XDR (20c)MIC500.25≥641≥64
MIC901≥6432≥64
range0.12–4≥640.5 to ≥64≥64

aIncludes 17 ESBL-producing and 5 carbapenemase-producing strains [OXA-48 (n = 3), NDM (n = 1) and KPC (n = 1)].

bIncludes three ESBL-producing and five carbapenemase-producing strains [VIM (n = 4) and IMP (n = 1)].

cIncludes 1 ESBL-producing and 10 carbapenemase-producing strains [OXA-23 (n = 9) and OXA-40 (n = 1)].

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