Activities of LPC-058, LPC-011, LPC-087 and the reference compound CHIR-90 against 234 clinical isolates of Enterobacteriaceae and 135 clinical isolates of non-fermentative Gram-negative bacilli
| Organism group (number of isolates tested) . | MIC (mg/L) . | LPC-058 . | LPC-011 . | LPC-087 . | CHIR-090 . |
|---|---|---|---|---|---|
| Enterobacteriaceae (234) | MIC50 | 0.06 | 0.12 | 0.25 | 0.5 |
| MIC90 | 0.12 | 0.25 | 0.5 | 2 | |
| range | ≤0.015–0.5 | ≤0.015–1 | ≤0.015–2 | 0.03–8 | |
| P. aeruginosa (51) | MIC50 | 0.25 | 0.5 | 2 | 2 |
| MIC90 | 0.5 | 1 | 4 | 4 | |
| range | 0.06–0.5 | 0.12–1 | 0.25–8 | 0.5–8 | |
| A. baumannii (26) | MIC50 | 0.25 | ≥64 | 1 | ≥64 |
| MIC90 | 1 | ≥64 | 32 | ≥64 | |
| range | 0.12–4 | — | 0.5 to ≥64 | — | |
| B. cepacia (22) | MIC50 | 0.5 | 4 | ≥64 | ≥64 |
| MIC90 | 1 | 8 | ≥64 | ≥64 | |
| range | 0.12–2 | 1–8 | — | — | |
| S. maltophilia (20) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — | |
| A. xylosoxidans (16) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — |
| Organism group (number of isolates tested) . | MIC (mg/L) . | LPC-058 . | LPC-011 . | LPC-087 . | CHIR-090 . |
|---|---|---|---|---|---|
| Enterobacteriaceae (234) | MIC50 | 0.06 | 0.12 | 0.25 | 0.5 |
| MIC90 | 0.12 | 0.25 | 0.5 | 2 | |
| range | ≤0.015–0.5 | ≤0.015–1 | ≤0.015–2 | 0.03–8 | |
| P. aeruginosa (51) | MIC50 | 0.25 | 0.5 | 2 | 2 |
| MIC90 | 0.5 | 1 | 4 | 4 | |
| range | 0.06–0.5 | 0.12–1 | 0.25–8 | 0.5–8 | |
| A. baumannii (26) | MIC50 | 0.25 | ≥64 | 1 | ≥64 |
| MIC90 | 1 | ≥64 | 32 | ≥64 | |
| range | 0.12–4 | — | 0.5 to ≥64 | — | |
| B. cepacia (22) | MIC50 | 0.5 | 4 | ≥64 | ≥64 |
| MIC90 | 1 | 8 | ≥64 | ≥64 | |
| range | 0.12–2 | 1–8 | — | — | |
| S. maltophilia (20) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — | |
| A. xylosoxidans (16) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — |
Activities of LPC-058, LPC-011, LPC-087 and the reference compound CHIR-90 against 234 clinical isolates of Enterobacteriaceae and 135 clinical isolates of non-fermentative Gram-negative bacilli
| Organism group (number of isolates tested) . | MIC (mg/L) . | LPC-058 . | LPC-011 . | LPC-087 . | CHIR-090 . |
|---|---|---|---|---|---|
| Enterobacteriaceae (234) | MIC50 | 0.06 | 0.12 | 0.25 | 0.5 |
| MIC90 | 0.12 | 0.25 | 0.5 | 2 | |
| range | ≤0.015–0.5 | ≤0.015–1 | ≤0.015–2 | 0.03–8 | |
| P. aeruginosa (51) | MIC50 | 0.25 | 0.5 | 2 | 2 |
| MIC90 | 0.5 | 1 | 4 | 4 | |
| range | 0.06–0.5 | 0.12–1 | 0.25–8 | 0.5–8 | |
| A. baumannii (26) | MIC50 | 0.25 | ≥64 | 1 | ≥64 |
| MIC90 | 1 | ≥64 | 32 | ≥64 | |
| range | 0.12–4 | — | 0.5 to ≥64 | — | |
| B. cepacia (22) | MIC50 | 0.5 | 4 | ≥64 | ≥64 |
| MIC90 | 1 | 8 | ≥64 | ≥64 | |
| range | 0.12–2 | 1–8 | — | — | |
| S. maltophilia (20) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — | |
| A. xylosoxidans (16) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — |
| Organism group (number of isolates tested) . | MIC (mg/L) . | LPC-058 . | LPC-011 . | LPC-087 . | CHIR-090 . |
|---|---|---|---|---|---|
| Enterobacteriaceae (234) | MIC50 | 0.06 | 0.12 | 0.25 | 0.5 |
| MIC90 | 0.12 | 0.25 | 0.5 | 2 | |
| range | ≤0.015–0.5 | ≤0.015–1 | ≤0.015–2 | 0.03–8 | |
| P. aeruginosa (51) | MIC50 | 0.25 | 0.5 | 2 | 2 |
| MIC90 | 0.5 | 1 | 4 | 4 | |
| range | 0.06–0.5 | 0.12–1 | 0.25–8 | 0.5–8 | |
| A. baumannii (26) | MIC50 | 0.25 | ≥64 | 1 | ≥64 |
| MIC90 | 1 | ≥64 | 32 | ≥64 | |
| range | 0.12–4 | — | 0.5 to ≥64 | — | |
| B. cepacia (22) | MIC50 | 0.5 | 4 | ≥64 | ≥64 |
| MIC90 | 1 | 8 | ≥64 | ≥64 | |
| range | 0.12–2 | 1–8 | — | — | |
| S. maltophilia (20) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — | |
| A. xylosoxidans (16) | MIC50 | ≥64 | ≥64 | ≥64 | ≥64 |
| MIC90 | ≥64 | ≥64 | ≥64 | ≥64 | |
| range | — | — | — | — |
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