Table 2 Open in new tab Event rate and...

	1-year follow-up (maximum)	10-year follow-up (maximum)
TE
Inpatients	3497 (58.0)	49 643	7.04 (6.81–7.28)	0.78	0.23 (0.46)	1	7890 (53.4)	183 476	4.30 (4.21–4.40)	2.87	1.27 (2.77)	1
Outpatients	1265 (30.8)	42 259	2.98 (2.82–3.15)	0.87	0.35 (0.50)	0.60 (0.56–0.64)	4027 (33.3)	176 261	2.28 (2.22–2.36)	3.62	1.94 (3.26)	0.74 (0.71–0.77)
ED patients	107 (40.2)	2850	3.75 (3.11–4.54)	0.85	0.28 (0.46)	0.88 (0.72–1.07)	284 (39.4)	12 336	2.30 (2.05–2.59)	3.68	1.67 (3.07)	0.89 (0.79–1.01)
Bleeding
Inpatients	2596 (22.7)	49 625	5.23 (5.03–5.44)	0.77	0.27 (0.48)	1	6447 (19.9)	183 110	3.52 (3.44–3.61)	2.86	1.48 (2.87)	1
Outpatients	1297 (15.2)	42 448	3.06 (2.89–3.22)	0.87	0.39 (0.49)	0.76 (0.71–0.81)	4255 (16.5)	175 756	2.42 (2.35–2.50)	3.61	2.06 (3.32)	0.87 (0.84–0.91)
ED patients	88 (22.7)	2856	3.08 (2.50–3.80)	0.88	0.36 (0.53)	0.84 (0.68–1.04)	264 (16.3)	12 341	2.14 (1.90–2.41)	3.68	1.87 (3.33)	0.89 (0.79–1.01)

1-year follow-up (maximum)

10-year follow-up (maximum)

Events (% fatal)

Person-years

Event rate (CI)

Mean follow-up time (years)

Median time to event, years (IQR)

Hazard ratio (CI)

Events (% fatal)

Person- years

Event rate (CI)

Mean follow-up time (years)

Median time to event, years (IQR)

Hazard ratio (CI)

Inpatients

3497 (58.0)

49 643

7.04 (6.81–7.28)

0.78

0.23 (0.46)

7890 (53.4)

183 476

4.30 (4.21–4.40)

2.87

1.27 (2.77)

Outpatients

1265 (30.8)

42 259

2.98 (2.82–3.15)

0.87

0.35 (0.50)

0.60 (0.56–0.64)

4027 (33.3)

176 261

2.28 (2.22–2.36)

3.62

1.94 (3.26)

0.74 (0.71–0.77)

ED patients

107 (40.2)

2850

3.75 (3.11–4.54)

0.85

0.28 (0.46)

0.88 (0.72–1.07)

284 (39.4)

12 336

2.30 (2.05–2.59)

3.68

1.67 (3.07)

0.89 (0.79–1.01)

Bleeding

Inpatients

2596 (22.7)

49 625

5.23 (5.03–5.44)

0.77

0.27 (0.48)

6447 (19.9)

183 110

3.52 (3.44–3.61)

2.86

1.48 (2.87)

Outpatients

1297 (15.2)

42 448

3.06 (2.89–3.22)

0.87

0.39 (0.49)

0.76 (0.71–0.81)

4255 (16.5)

175 756

2.42 (2.35–2.50)

3.61

2.06 (3.32)

0.87 (0.84–0.91)

ED patients

88 (22.7)

2856

3.08 (2.50–3.80)

0.88

0.36 (0.53)

0.84 (0.68–1.04)

264 (16.3)

12 341

2.14 (1.90–2.41)

3.68

1.87 (3.33)

0.89 (0.79–1.01)

	1-year follow-up (maximum)	10-year follow-up (maximum)
TE
Inpatients	3497 (58.0)	49 643	7.04 (6.81–7.28)	0.78	0.23 (0.46)	1	7890 (53.4)	183 476	4.30 (4.21–4.40)	2.87	1.27 (2.77)	1
Outpatients	1265 (30.8)	42 259	2.98 (2.82–3.15)	0.87	0.35 (0.50)	0.60 (0.56–0.64)	4027 (33.3)	176 261	2.28 (2.22–2.36)	3.62	1.94 (3.26)	0.74 (0.71–0.77)
ED patients	107 (40.2)	2850	3.75 (3.11–4.54)	0.85	0.28 (0.46)	0.88 (0.72–1.07)	284 (39.4)	12 336	2.30 (2.05–2.59)	3.68	1.67 (3.07)	0.89 (0.79–1.01)
Bleeding
Inpatients	2596 (22.7)	49 625	5.23 (5.03–5.44)	0.77	0.27 (0.48)	1	6447 (19.9)	183 110	3.52 (3.44–3.61)	2.86	1.48 (2.87)	1
Outpatients	1297 (15.2)	42 448	3.06 (2.89–3.22)	0.87	0.39 (0.49)	0.76 (0.71–0.81)	4255 (16.5)	175 756	2.42 (2.35–2.50)	3.61	2.06 (3.32)	0.87 (0.84–0.91)
ED patients	88 (22.7)	2856	3.08 (2.50–3.80)	0.88	0.36 (0.53)	0.84 (0.68–1.04)	264 (16.3)	12 341	2.14 (1.90–2.41)	3.68	1.87 (3.33)	0.89 (0.79–1.01)

Table 2

Open in new tab

Event rate and risk of TE and bleeding of patients stratified according to the healthcare setting first diagnosing AF

	1-year follow-up (maximum)						10-year follow-up (maximum)
	Events (% fatal)	Person-years	Event rate (CI)	Mean follow-up time (years)	Median time to event, years (IQR)	Hazard ratio (CI)	Events (% fatal)	Person- years	Event rate (CI)	Mean follow-up time (years)	Median time to event, years (IQR)	Hazard ratio (CI)
TE
Inpatients	3497 (58.0)	49 643	7.04 (6.81–7.28)	0.78	0.23 (0.46)	1	7890 (53.4)	183 476	4.30 (4.21–4.40)	2.87	1.27 (2.77)	1
Outpatients	1265 (30.8)	42 259	2.98 (2.82–3.15)	0.87	0.35 (0.50)	0.60 (0.56–0.64)	4027 (33.3)	176 261	2.28 (2.22–2.36)	3.62	1.94 (3.26)	0.74 (0.71–0.77)
ED patients	107 (40.2)	2850	3.75 (3.11–4.54)	0.85	0.28 (0.46)	0.88 (0.72–1.07)	284 (39.4)	12 336	2.30 (2.05–2.59)	3.68	1.67 (3.07)	0.89 (0.79–1.01)
Bleeding
Inpatients	2596 (22.7)	49 625	5.23 (5.03–5.44)	0.77	0.27 (0.48)	1	6447 (19.9)	183 110	3.52 (3.44–3.61)	2.86	1.48 (2.87)	1
Outpatients	1297 (15.2)	42 448	3.06 (2.89–3.22)	0.87	0.39 (0.49)	0.76 (0.71–0.81)	4255 (16.5)	175 756	2.42 (2.35–2.50)	3.61	2.06 (3.32)	0.87 (0.84–0.91)
ED patients	88 (22.7)	2856	3.08 (2.50–3.80)	0.88	0.36 (0.53)	0.84 (0.68–1.04)	264 (16.3)	12 341	2.14 (1.90–2.41)	3.68	1.87 (3.33)	0.89 (0.79–1.01)

	1-year follow-up (maximum)						10-year follow-up (maximum)
	Events (% fatal)	Person-years	Event rate (CI)	Mean follow-up time (years)	Median time to event, years (IQR)	Hazard ratio (CI)	Events (% fatal)	Person- years	Event rate (CI)	Mean follow-up time (years)	Median time to event, years (IQR)	Hazard ratio (CI)
TE
Inpatients	3497 (58.0)	49 643	7.04 (6.81–7.28)	0.78	0.23 (0.46)	1	7890 (53.4)	183 476	4.30 (4.21–4.40)	2.87	1.27 (2.77)	1
Outpatients	1265 (30.8)	42 259	2.98 (2.82–3.15)	0.87	0.35 (0.50)	0.60 (0.56–0.64)	4027 (33.3)	176 261	2.28 (2.22–2.36)	3.62	1.94 (3.26)	0.74 (0.71–0.77)
ED patients	107 (40.2)	2850	3.75 (3.11–4.54)	0.85	0.28 (0.46)	0.88 (0.72–1.07)	284 (39.4)	12 336	2.30 (2.05–2.59)	3.68	1.67 (3.07)	0.89 (0.79–1.01)
Bleeding
Inpatients	2596 (22.7)	49 625	5.23 (5.03–5.44)	0.77	0.27 (0.48)	1	6447 (19.9)	183 110	3.52 (3.44–3.61)	2.86	1.48 (2.87)	1
Outpatients	1297 (15.2)	42 448	3.06 (2.89–3.22)	0.87	0.39 (0.49)	0.76 (0.71–0.81)	4255 (16.5)	175 756	2.42 (2.35–2.50)	3.61	2.06 (3.32)	0.87 (0.84–0.91)
ED patients	88 (22.7)	2856	3.08 (2.50–3.80)	0.88	0.36 (0.53)	0.84 (0.68–1.04)	264 (16.3)	12 341	2.14 (1.90–2.41)	3.68	1.87 (3.33)	0.89 (0.79–1.01)

Event rates are unadjusted and displayed per 100 person-years. HRs calculated using Cox regression analysis adjusted for sex, age, and year of inclusion. TE and bleeding outcomes were adjusted for CHA₂DS₂-VASc and HAS-BLED scores, respectively. Inpatients were used as reference. AF, atrial fibrillation; CI, confidence interval; IQR, interquartile range; TE, thrombo-embolism; ED, emergency department.

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