Comparison of Peptide Sequences Present in the Multiepitope (ME) String Fused to Thrombospondin-Related Adhesion Protein and the T-Cell Region of RTS,S
| Epitope Sequence . | CS Amino Acid Position (Length) . | Epitope Type . | Present in ME String . | Present in RTS,S . | Present in ELISPOT CS Peptides . | ELISPOT Pool Number . |
|---|---|---|---|---|---|---|
| DPNANPNVDP NANPNV | 111–126 (16) | CD4 | Yes | No | Yes, DNANPN only | 1 |
| NMPNDPN RNV | 286–293 (8) | CD8 | Yes | Yes | Yes, PNDPN RNV only | 1 |
| YL NKIQNSL | 319–327 (9) | CD8 | Yes | Yes | Yes, full length | 2 |
| KPKDELDY | 353–360 (8) | CD8 | Yes | Yes | Yes, full length | 3 |
| Epitope Sequence . | CS Amino Acid Position (Length) . | Epitope Type . | Present in ME String . | Present in RTS,S . | Present in ELISPOT CS Peptides . | ELISPOT Pool Number . |
|---|---|---|---|---|---|---|
| DPNANPNVDP NANPNV | 111–126 (16) | CD4 | Yes | No | Yes, DNANPN only | 1 |
| NMPNDPN RNV | 286–293 (8) | CD8 | Yes | Yes | Yes, PNDPN RNV only | 1 |
| YL NKIQNSL | 319–327 (9) | CD8 | Yes | Yes | Yes, full length | 2 |
| KPKDELDY | 353–360 (8) | CD8 | Yes | Yes | Yes, full length | 3 |
Data are from Lalvani et al [21].
Abbreviations: CS, circumsporozoite protein; ELISPOT, enzyme-linked immunospot.
Comparison of Peptide Sequences Present in the Multiepitope (ME) String Fused to Thrombospondin-Related Adhesion Protein and the T-Cell Region of RTS,S
| Epitope Sequence . | CS Amino Acid Position (Length) . | Epitope Type . | Present in ME String . | Present in RTS,S . | Present in ELISPOT CS Peptides . | ELISPOT Pool Number . |
|---|---|---|---|---|---|---|
| DPNANPNVDP NANPNV | 111–126 (16) | CD4 | Yes | No | Yes, DNANPN only | 1 |
| NMPNDPN RNV | 286–293 (8) | CD8 | Yes | Yes | Yes, PNDPN RNV only | 1 |
| YL NKIQNSL | 319–327 (9) | CD8 | Yes | Yes | Yes, full length | 2 |
| KPKDELDY | 353–360 (8) | CD8 | Yes | Yes | Yes, full length | 3 |
| Epitope Sequence . | CS Amino Acid Position (Length) . | Epitope Type . | Present in ME String . | Present in RTS,S . | Present in ELISPOT CS Peptides . | ELISPOT Pool Number . |
|---|---|---|---|---|---|---|
| DPNANPNVDP NANPNV | 111–126 (16) | CD4 | Yes | No | Yes, DNANPN only | 1 |
| NMPNDPN RNV | 286–293 (8) | CD8 | Yes | Yes | Yes, PNDPN RNV only | 1 |
| YL NKIQNSL | 319–327 (9) | CD8 | Yes | Yes | Yes, full length | 2 |
| KPKDELDY | 353–360 (8) | CD8 | Yes | Yes | Yes, full length | 3 |
Data are from Lalvani et al [21].
Abbreviations: CS, circumsporozoite protein; ELISPOT, enzyme-linked immunospot.
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