Table 6. Open in new tab Correlation...

Variable	First-Time ZV Recipients Aged ≥50 Years Old (Groups 2–4)	Booster ZV Recipients Aged ≥70 Years Old (Group 1)
Baseline gpELISA findings
Total effector	393	0.091	.072	195	0.104	.147
Effector memory	390	0.137	.007	194	0.102	.157
Total memory	393	0.075	.138	196	0.074	.304
Central memory	379	0.055	.283	194	0.0414	.566
Differentiated effector	344	0.057	.293	161	0.0904	.256
Week 6 gpELISA and week 1 ELISPOT findings
Total effector	386	0.218	<.0001	198	0.222	.002
Effector memory	385	0.295	<.0001	196	0.168	.019
Total memory	386	0.2165	<.0001	194	0.224	.002
Central memory	378	0.148	.004	192	0.284	<.0001
Differentiated effector	375	0.20321	<.0001	195	0.229	.001
Week 6 gpELISA and week 6 ELISPOT findings
Total effector	387	0.233	<.0001	198	0.166	.020
Effector memory	385	0.255	<.0001	197	0.174	.015
Total memory	390	0.182	.001	194	0.137	.056
Central memory	382	0.061	.2316	192	0.082	.260
Differentiated effector	354	0.152	.004	180	0.226	.002
Week 6 gpELISA and week 52 ELISPOT findings
Total effector	342	0.167	.002	182	0.183	.013
Effector memory	340	0.12587	.020	181	0.179	.016
Total memory	344	0.107	.048	180	0.107	.152
Central memory	335	0.061	.263	176	0.144	.056
Differentiated effector	308	0.157	.006	165	0.094	.232
Week 6/baseline gpELISA and week 1 ELISPOT findings
Total effector	386	0.140	.006	198	0.084	.239
Effector memory	385	0.144	.005	196	0.091	.205
Total memory	386	0.131	.010	194	0.124	.085
Central memory	378	0.093	.070	192	0.127	.079
Differentiated effector	375	0.113	.029	195	0.034	.635
Week 6 gpELISA/baseline and week 6 ELISPOT findings
Total effector	387	0.139	.006	198	0.025	.726
Effector memory	385	0.130	.010	197	0.050	.484
Total memory	390	0.106	.036	194	0.061	.402
Central memory	382	0.068	.188	192	0.038	.598
Differentiated effector	354	0.106	.046	180	0.011	.885
Week 6/baseline gpELISA and week 52 ELISPOT findings
Total effector	342	0.198	<.001	182	−0.007	.922
Effector memory	340	0.210	.0001	181	0.021	.776
Total memory	344	0.176	.001	180	0.016	.830
Central memory	335	0.094	.084	176	0.031	.679
Differentiated effector	308	0.122	.033	165	−0.070	.370

Variable

First-Time ZV Recipients Aged ≥50 Years Old (Groups 2–4)

Booster ZV Recipients Aged ≥70 Years Old (Group 1)

Participants, No.

Coefficient of Correlation

P Value

Participants, No.

Coefficient of Correlation

P Value

Baseline gpELISA findings

Total effector

393

0.091

.072

195

0.104

.147

Effector memory

390

0.137

.007

194

0.102

.157

Total memory

393

0.075

.138

196

0.074

.304

Central memory

379

0.055

.283

194

0.0414

.566

Differentiated effector

344

0.057

.293

161

0.0904

.256

Week 6 gpELISA and week 1 ELISPOT findings

Total effector

386

0.218

<.0001

198

0.222

.002

Effector memory

385

0.295

<.0001

196

0.168

.019

Total memory

386

0.2165

<.0001

194

0.224

.002

Central memory

378

0.148

.004

192

0.284

<.0001

Differentiated effector

375

0.20321

<.0001

195

0.229

.001

Week 6 gpELISA and week 6 ELISPOT findings

Total effector

387

0.233

<.0001

198

0.166

.020

Effector memory

385

0.255

<.0001

197

0.174

.015

Total memory

390

0.182

.001

194

0.137

.056

Central memory

382

0.061

.2316

192

0.082

.260

Differentiated effector

354

0.152

.004

180

0.226

.002

Week 6 gpELISA and week 52 ELISPOT findings

Total effector

342

0.167

.002

182

0.183

.013

Effector memory

340

0.12587

.020

181

0.179

.016

Total memory

344

0.107

.048

180

0.107

.152

Central memory

335

0.061

.263

176

0.144

.056

Differentiated effector

308

0.157

.006

165

0.094

.232

Week 6/baseline gpELISA and week 1 ELISPOT findings

Total effector

386

0.140

.006

198

0.084

.239

Effector memory

385

0.144

.005

196

0.091

.205

Total memory

386

0.131

.010

194

0.124

.085

Central memory

378

0.093

.070

192

0.127

.079

Differentiated effector

375

0.113

.029

195

0.034

.635

Week 6 gpELISA/baseline and week 6 ELISPOT findings

Total effector

387

0.139

.006

198

0.025

.726

Effector memory

385

0.130

.010

197

0.050

.484

Total memory

390

0.106

.036

194

0.061

.402

Central memory

382

0.068

.188

192

0.038

.598

Differentiated effector

354

0.106

.046

180

0.011

.885

Week 6/baseline gpELISA and week 52 ELISPOT findings

Total effector

342

0.198

<.001

182

−0.007

.922

Effector memory

340

0.210

.0001

181

0.021

.776

Total memory

344

0.176

.001

180

0.016

.830

Central memory

335

0.094

.084

176

0.031

.679

Differentiated effector

308

0.122

.033

165

−0.070

.370

Variable	First-Time ZV Recipients Aged ≥50 Years Old (Groups 2–4)	Booster ZV Recipients Aged ≥70 Years Old (Group 1)
Baseline gpELISA findings
Total effector	393	0.091	.072	195	0.104	.147
Effector memory	390	0.137	.007	194	0.102	.157
Total memory	393	0.075	.138	196	0.074	.304
Central memory	379	0.055	.283	194	0.0414	.566
Differentiated effector	344	0.057	.293	161	0.0904	.256
Week 6 gpELISA and week 1 ELISPOT findings
Total effector	386	0.218	<.0001	198	0.222	.002
Effector memory	385	0.295	<.0001	196	0.168	.019
Total memory	386	0.2165	<.0001	194	0.224	.002
Central memory	378	0.148	.004	192	0.284	<.0001
Differentiated effector	375	0.20321	<.0001	195	0.229	.001
Week 6 gpELISA and week 6 ELISPOT findings
Total effector	387	0.233	<.0001	198	0.166	.020
Effector memory	385	0.255	<.0001	197	0.174	.015
Total memory	390	0.182	.001	194	0.137	.056
Central memory	382	0.061	.2316	192	0.082	.260
Differentiated effector	354	0.152	.004	180	0.226	.002
Week 6 gpELISA and week 52 ELISPOT findings
Total effector	342	0.167	.002	182	0.183	.013
Effector memory	340	0.12587	.020	181	0.179	.016
Total memory	344	0.107	.048	180	0.107	.152
Central memory	335	0.061	.263	176	0.144	.056
Differentiated effector	308	0.157	.006	165	0.094	.232
Week 6/baseline gpELISA and week 1 ELISPOT findings
Total effector	386	0.140	.006	198	0.084	.239
Effector memory	385	0.144	.005	196	0.091	.205
Total memory	386	0.131	.010	194	0.124	.085
Central memory	378	0.093	.070	192	0.127	.079
Differentiated effector	375	0.113	.029	195	0.034	.635
Week 6 gpELISA/baseline and week 6 ELISPOT findings
Total effector	387	0.139	.006	198	0.025	.726
Effector memory	385	0.130	.010	197	0.050	.484
Total memory	390	0.106	.036	194	0.061	.402
Central memory	382	0.068	.188	192	0.038	.598
Differentiated effector	354	0.106	.046	180	0.011	.885
Week 6/baseline gpELISA and week 52 ELISPOT findings
Total effector	342	0.198	<.001	182	−0.007	.922
Effector memory	340	0.210	.0001	181	0.021	.776
Total memory	344	0.176	.001	180	0.016	.830
Central memory	335	0.094	.084	176	0.031	.679
Differentiated effector	308	0.122	.033	165	−0.070	.370

Table 6.

Open in new tab

Correlation Between Varicella Zoster Virus (VZV)–Specific Cell-Mediated and Humoral Immunity After Zoster Vaccine (ZV) Administration, Using Pooled Analysis

Variable	First-Time ZV Recipients Aged ≥50 Years Old (Groups 2–4)			Booster ZV Recipients Aged ≥70 Years Old (Group 1)
Variable	Participants, No.	Coefficient of Correlation	P Value	Participants, No.	Coefficient of Correlation	P Value
Baseline gpELISA findings
Total effector	393	0.091	.072	195	0.104	.147
Effector memory	390	0.137	.007	194	0.102	.157
Total memory	393	0.075	.138	196	0.074	.304
Central memory	379	0.055	.283	194	0.0414	.566
Differentiated effector	344	0.057	.293	161	0.0904	.256
Week 6 gpELISA and week 1 ELISPOT findings
Total effector	386	0.218	<.0001	198	0.222	.002
Effector memory	385	0.295	<.0001	196	0.168	.019
Total memory	386	0.2165	<.0001	194	0.224	.002
Central memory	378	0.148	.004	192	0.284	<.0001
Differentiated effector	375	0.20321	<.0001	195	0.229	.001
Week 6 gpELISA and week 6 ELISPOT findings
Total effector	387	0.233	<.0001	198	0.166	.020
Effector memory	385	0.255	<.0001	197	0.174	.015
Total memory	390	0.182	.001	194	0.137	.056
Central memory	382	0.061	.2316	192	0.082	.260
Differentiated effector	354	0.152	.004	180	0.226	.002
Week 6 gpELISA and week 52 ELISPOT findings
Total effector	342	0.167	.002	182	0.183	.013
Effector memory	340	0.12587	.020	181	0.179	.016
Total memory	344	0.107	.048	180	0.107	.152
Central memory	335	0.061	.263	176	0.144	.056
Differentiated effector	308	0.157	.006	165	0.094	.232
Week 6/baseline gpELISA and week 1 ELISPOT findings
Total effector	386	0.140	.006	198	0.084	.239
Effector memory	385	0.144	.005	196	0.091	.205
Total memory	386	0.131	.010	194	0.124	.085
Central memory	378	0.093	.070	192	0.127	.079
Differentiated effector	375	0.113	.029	195	0.034	.635
Week 6 gpELISA/baseline and week 6 ELISPOT findings
Total effector	387	0.139	.006	198	0.025	.726
Effector memory	385	0.130	.010	197	0.050	.484
Total memory	390	0.106	.036	194	0.061	.402
Central memory	382	0.068	.188	192	0.038	.598
Differentiated effector	354	0.106	.046	180	0.011	.885
Week 6/baseline gpELISA and week 52 ELISPOT findings
Total effector	342	0.198	<.001	182	−0.007	.922
Effector memory	340	0.210	.0001	181	0.021	.776
Total memory	344	0.176	.001	180	0.016	.830
Central memory	335	0.094	.084	176	0.031	.679
Differentiated effector	308	0.122	.033	165	−0.070	.370

Variable	First-Time ZV Recipients Aged ≥50 Years Old (Groups 2–4)			Booster ZV Recipients Aged ≥70 Years Old (Group 1)
Variable	Participants, No.	Coefficient of Correlation	P Value	Participants, No.	Coefficient of Correlation	P Value
Baseline gpELISA findings
Total effector	393	0.091	.072	195	0.104	.147
Effector memory	390	0.137	.007	194	0.102	.157
Total memory	393	0.075	.138	196	0.074	.304
Central memory	379	0.055	.283	194	0.0414	.566
Differentiated effector	344	0.057	.293	161	0.0904	.256
Week 6 gpELISA and week 1 ELISPOT findings
Total effector	386	0.218	<.0001	198	0.222	.002
Effector memory	385	0.295	<.0001	196	0.168	.019
Total memory	386	0.2165	<.0001	194	0.224	.002
Central memory	378	0.148	.004	192	0.284	<.0001
Differentiated effector	375	0.20321	<.0001	195	0.229	.001
Week 6 gpELISA and week 6 ELISPOT findings
Total effector	387	0.233	<.0001	198	0.166	.020
Effector memory	385	0.255	<.0001	197	0.174	.015
Total memory	390	0.182	.001	194	0.137	.056
Central memory	382	0.061	.2316	192	0.082	.260
Differentiated effector	354	0.152	.004	180	0.226	.002
Week 6 gpELISA and week 52 ELISPOT findings
Total effector	342	0.167	.002	182	0.183	.013
Effector memory	340	0.12587	.020	181	0.179	.016
Total memory	344	0.107	.048	180	0.107	.152
Central memory	335	0.061	.263	176	0.144	.056
Differentiated effector	308	0.157	.006	165	0.094	.232
Week 6/baseline gpELISA and week 1 ELISPOT findings
Total effector	386	0.140	.006	198	0.084	.239
Effector memory	385	0.144	.005	196	0.091	.205
Total memory	386	0.131	.010	194	0.124	.085
Central memory	378	0.093	.070	192	0.127	.079
Differentiated effector	375	0.113	.029	195	0.034	.635
Week 6 gpELISA/baseline and week 6 ELISPOT findings
Total effector	387	0.139	.006	198	0.025	.726
Effector memory	385	0.130	.010	197	0.050	.484
Total memory	390	0.106	.036	194	0.061	.402
Central memory	382	0.068	.188	192	0.038	.598
Differentiated effector	354	0.106	.046	180	0.011	.885
Week 6/baseline gpELISA and week 52 ELISPOT findings
Total effector	342	0.198	<.001	182	−0.007	.922
Effector memory	340	0.210	.0001	181	0.021	.776
Total memory	344	0.176	.001	180	0.016	.830
Central memory	335	0.094	.084	176	0.031	.679
Differentiated effector	308	0.122	.033	165	−0.070	.370

Total effector cells were measured on the basis of spot-forming cells (SFCs) secreting interferon γ (IFN-γ), with or without secretion of interleukin 2 (IL-2); effector memory cells were measured on the basis of SFCs secreting IFN-γ and IL-2; total memory cells were measured on the basis of SFCs secreting IL-2, with or without secretion of IFN-γ; central memory cells were measured on the basis of SFCs secreting IL-2 but not IFN-γ; and differentiated effector cells were measured on the basis of SFCs secreting IFN-γ but not IL-2.

Abbreviations: ELISPOT, enzyme-linked immunosorbent spot; gpELISA, VZV glycoprotein–based enzyme-linked immunosorbent assay.

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