Table 1.

Descriptive Characteristics of Subjects With Medically Attended Acute Respiratory Illness, by Influenza Virus Infection Status

CharacteristicA(H1N1)pdm09-Positive Cases (n = 1022)Influenza Virus–Positive Cases (n = 1197)Influenza Virus–Negative Controls (n = 4440)P Valuea
Site<.001
 Michigan126 (12)141 (12)618 (14)
 Pennsylvania277 (27)297 (25)812 (18)
 Texas135 (13)176 (15)780 (18)
 Washington191 (19)240 (20)1310 (30)
 Wisconsin293 (29)343 (29)920 (21)
Age<.001
 6 mo–8 y151 (15)171 (14)954 (21)
 9–17 y79 (8)110 (9)515 (12)
 18–49 y476 (47)545 (46)1623 (37)
 50–64 y235 (23)269 (22)827 (19)
 ≥65 y81 (8)102 (9)521 (12)
Male sex450 (44)530 (44)1837 (41).071
Race/ethnicityb.012
 White, non-Hispanic819 (80)958 (80)3372 (76)
 Black, non-Hispanic76 (7)85 (7)322 (7)
 Hispanic61 (6)77 (6)357 (8)
 Other, non-Hispanic65 (6)76 (6)322 (7)
High-risk condition<.001
 Any311 (30)365 (30)1800 (41)
 Asthma/pulmonary135 (13)158 (13)929 (21)
 Cardiovascular81 (8)100 (8)512 (12)
 Diabetes54 (5)62 (5)348 (8)
 Morbid obesityc64 (7)75 (7)338 (8)
 Other108 (11)127 (11)557 (13)
Vaccination status 2013–2014<.0001
 Inactivated vaccined275 (27)335 (28)2215 (50)
 Vaccinated with IIV3e195 (19)235 (20)1544 (35)
 Vaccinated with IIV4e30 (3)37 (3)285 (6)
 Vaccinated with LAIV4d32 (3)42 (4)159 (4)
 Vaccinated with other/unknown typed13 (1)17 (1)60 (1)
 Unvaccinatedd702 (69)803 (67)2006 (45)
Interval from illness onset to enrollment<.001
 0–2 d476 (47)526 (44)1282 (29)
 3–4 d347 (34)413 (35)1714 (39)
 5–7 d199 (19)258 (22)1444 (33)
Reported general health statusf.009
 Excellent/very good744 (73)881 (74)3070 (69)
 Good206 (20)239 (20)1062 (24)
 Fair/poor71 (7)76 (6)305 (7)
Self/household exposure to smoke191 (19)211 (18)636 (14).005
Children ages <12 y in household, no.g.041
 0570 (56)669 (56)2308 (52)
 1192 (19)223 (19)938 (21)
 ≥2260 (25)305 (25)1191 (27)
Reported current health assessment score, median (IQR)h50 (40–70)50 (40–70)60 (50–75)<.001
CharacteristicA(H1N1)pdm09-Positive Cases (n = 1022)Influenza Virus–Positive Cases (n = 1197)Influenza Virus–Negative Controls (n = 4440)P Valuea
Site<.001
 Michigan126 (12)141 (12)618 (14)
 Pennsylvania277 (27)297 (25)812 (18)
 Texas135 (13)176 (15)780 (18)
 Washington191 (19)240 (20)1310 (30)
 Wisconsin293 (29)343 (29)920 (21)
Age<.001
 6 mo–8 y151 (15)171 (14)954 (21)
 9–17 y79 (8)110 (9)515 (12)
 18–49 y476 (47)545 (46)1623 (37)
 50–64 y235 (23)269 (22)827 (19)
 ≥65 y81 (8)102 (9)521 (12)
Male sex450 (44)530 (44)1837 (41).071
Race/ethnicityb.012
 White, non-Hispanic819 (80)958 (80)3372 (76)
 Black, non-Hispanic76 (7)85 (7)322 (7)
 Hispanic61 (6)77 (6)357 (8)
 Other, non-Hispanic65 (6)76 (6)322 (7)
High-risk condition<.001
 Any311 (30)365 (30)1800 (41)
 Asthma/pulmonary135 (13)158 (13)929 (21)
 Cardiovascular81 (8)100 (8)512 (12)
 Diabetes54 (5)62 (5)348 (8)
 Morbid obesityc64 (7)75 (7)338 (8)
 Other108 (11)127 (11)557 (13)
Vaccination status 2013–2014<.0001
 Inactivated vaccined275 (27)335 (28)2215 (50)
 Vaccinated with IIV3e195 (19)235 (20)1544 (35)
 Vaccinated with IIV4e30 (3)37 (3)285 (6)
 Vaccinated with LAIV4d32 (3)42 (4)159 (4)
 Vaccinated with other/unknown typed13 (1)17 (1)60 (1)
 Unvaccinatedd702 (69)803 (67)2006 (45)
Interval from illness onset to enrollment<.001
 0–2 d476 (47)526 (44)1282 (29)
 3–4 d347 (34)413 (35)1714 (39)
 5–7 d199 (19)258 (22)1444 (33)
Reported general health statusf.009
 Excellent/very good744 (73)881 (74)3070 (69)
 Good206 (20)239 (20)1062 (24)
 Fair/poor71 (7)76 (6)305 (7)
Self/household exposure to smoke191 (19)211 (18)636 (14).005
Children ages <12 y in household, no.g.041
 0570 (56)669 (56)2308 (52)
 1192 (19)223 (19)938 (21)
 ≥2260 (25)305 (25)1191 (27)
Reported current health assessment score, median (IQR)h50 (40–70)50 (40–70)60 (50–75)<.001

Data are no. (%) of subjects, unless otherwise indicated.

Abbreviations: A(H1N1)pdm09, 2009 pandemic influenza A(H1N1) virus; BMI, body mass index; EIR, electronic immunization record (includes electronic medical record, employee health record, and state immunization registry); IIV3/4, inactivated influenza vaccine, trivalent/quadrivalent; IQR, interquartile range; LAIV4, live attenuated influenza vaccine, quadrivalent.

a The χ2 statistic was used to assess differences between the numbers of persons with influenza virus–negative and influenza virus–positive test results, with respect to the distributions of site, age group, sex, race/ethnicity, presence of any high-risk condition, vaccination status, interval from illness onset to enrollment, general health status, self or household exposure to smoke, and number of children ages <12 years in the household. The Wilcoxon–Mann–Whitney test was used to assess differences with respect to the distribution of the current health assessment. A P value of <.05 is statistically significant.

b Data were missing for 10 enrollees.

c Defined as a body mass index of ≥40, calculated as the weight in kilograms divided by the height in meters squared. Data were missing for 312 enrollees.

d Vaccination status (≥14 days prior to illness onset) was determined by a combination of EIR and plausible off-site self-report or report by the parent or guardian. Persons aged ≥50 years with unknown vaccine type were assumed to have received inactivated vaccine (Figure 1).

e Vaccination status (≥14 days prior to illness onset) determined by EIR.

f Data were missing for 4 enrollees.

g Data were missing for 3 enrollees.

h Possible values range from 1 (the worst) to 100 (the best). Data were missing for 6 enrollees.

Table 1.

Descriptive Characteristics of Subjects With Medically Attended Acute Respiratory Illness, by Influenza Virus Infection Status

CharacteristicA(H1N1)pdm09-Positive Cases (n = 1022)Influenza Virus–Positive Cases (n = 1197)Influenza Virus–Negative Controls (n = 4440)P Valuea
Site<.001
 Michigan126 (12)141 (12)618 (14)
 Pennsylvania277 (27)297 (25)812 (18)
 Texas135 (13)176 (15)780 (18)
 Washington191 (19)240 (20)1310 (30)
 Wisconsin293 (29)343 (29)920 (21)
Age<.001
 6 mo–8 y151 (15)171 (14)954 (21)
 9–17 y79 (8)110 (9)515 (12)
 18–49 y476 (47)545 (46)1623 (37)
 50–64 y235 (23)269 (22)827 (19)
 ≥65 y81 (8)102 (9)521 (12)
Male sex450 (44)530 (44)1837 (41).071
Race/ethnicityb.012
 White, non-Hispanic819 (80)958 (80)3372 (76)
 Black, non-Hispanic76 (7)85 (7)322 (7)
 Hispanic61 (6)77 (6)357 (8)
 Other, non-Hispanic65 (6)76 (6)322 (7)
High-risk condition<.001
 Any311 (30)365 (30)1800 (41)
 Asthma/pulmonary135 (13)158 (13)929 (21)
 Cardiovascular81 (8)100 (8)512 (12)
 Diabetes54 (5)62 (5)348 (8)
 Morbid obesityc64 (7)75 (7)338 (8)
 Other108 (11)127 (11)557 (13)
Vaccination status 2013–2014<.0001
 Inactivated vaccined275 (27)335 (28)2215 (50)
 Vaccinated with IIV3e195 (19)235 (20)1544 (35)
 Vaccinated with IIV4e30 (3)37 (3)285 (6)
 Vaccinated with LAIV4d32 (3)42 (4)159 (4)
 Vaccinated with other/unknown typed13 (1)17 (1)60 (1)
 Unvaccinatedd702 (69)803 (67)2006 (45)
Interval from illness onset to enrollment<.001
 0–2 d476 (47)526 (44)1282 (29)
 3–4 d347 (34)413 (35)1714 (39)
 5–7 d199 (19)258 (22)1444 (33)
Reported general health statusf.009
 Excellent/very good744 (73)881 (74)3070 (69)
 Good206 (20)239 (20)1062 (24)
 Fair/poor71 (7)76 (6)305 (7)
Self/household exposure to smoke191 (19)211 (18)636 (14).005
Children ages <12 y in household, no.g.041
 0570 (56)669 (56)2308 (52)
 1192 (19)223 (19)938 (21)
 ≥2260 (25)305 (25)1191 (27)
Reported current health assessment score, median (IQR)h50 (40–70)50 (40–70)60 (50–75)<.001
CharacteristicA(H1N1)pdm09-Positive Cases (n = 1022)Influenza Virus–Positive Cases (n = 1197)Influenza Virus–Negative Controls (n = 4440)P Valuea
Site<.001
 Michigan126 (12)141 (12)618 (14)
 Pennsylvania277 (27)297 (25)812 (18)
 Texas135 (13)176 (15)780 (18)
 Washington191 (19)240 (20)1310 (30)
 Wisconsin293 (29)343 (29)920 (21)
Age<.001
 6 mo–8 y151 (15)171 (14)954 (21)
 9–17 y79 (8)110 (9)515 (12)
 18–49 y476 (47)545 (46)1623 (37)
 50–64 y235 (23)269 (22)827 (19)
 ≥65 y81 (8)102 (9)521 (12)
Male sex450 (44)530 (44)1837 (41).071
Race/ethnicityb.012
 White, non-Hispanic819 (80)958 (80)3372 (76)
 Black, non-Hispanic76 (7)85 (7)322 (7)
 Hispanic61 (6)77 (6)357 (8)
 Other, non-Hispanic65 (6)76 (6)322 (7)
High-risk condition<.001
 Any311 (30)365 (30)1800 (41)
 Asthma/pulmonary135 (13)158 (13)929 (21)
 Cardiovascular81 (8)100 (8)512 (12)
 Diabetes54 (5)62 (5)348 (8)
 Morbid obesityc64 (7)75 (7)338 (8)
 Other108 (11)127 (11)557 (13)
Vaccination status 2013–2014<.0001
 Inactivated vaccined275 (27)335 (28)2215 (50)
 Vaccinated with IIV3e195 (19)235 (20)1544 (35)
 Vaccinated with IIV4e30 (3)37 (3)285 (6)
 Vaccinated with LAIV4d32 (3)42 (4)159 (4)
 Vaccinated with other/unknown typed13 (1)17 (1)60 (1)
 Unvaccinatedd702 (69)803 (67)2006 (45)
Interval from illness onset to enrollment<.001
 0–2 d476 (47)526 (44)1282 (29)
 3–4 d347 (34)413 (35)1714 (39)
 5–7 d199 (19)258 (22)1444 (33)
Reported general health statusf.009
 Excellent/very good744 (73)881 (74)3070 (69)
 Good206 (20)239 (20)1062 (24)
 Fair/poor71 (7)76 (6)305 (7)
Self/household exposure to smoke191 (19)211 (18)636 (14).005
Children ages <12 y in household, no.g.041
 0570 (56)669 (56)2308 (52)
 1192 (19)223 (19)938 (21)
 ≥2260 (25)305 (25)1191 (27)
Reported current health assessment score, median (IQR)h50 (40–70)50 (40–70)60 (50–75)<.001

Data are no. (%) of subjects, unless otherwise indicated.

Abbreviations: A(H1N1)pdm09, 2009 pandemic influenza A(H1N1) virus; BMI, body mass index; EIR, electronic immunization record (includes electronic medical record, employee health record, and state immunization registry); IIV3/4, inactivated influenza vaccine, trivalent/quadrivalent; IQR, interquartile range; LAIV4, live attenuated influenza vaccine, quadrivalent.

a The χ2 statistic was used to assess differences between the numbers of persons with influenza virus–negative and influenza virus–positive test results, with respect to the distributions of site, age group, sex, race/ethnicity, presence of any high-risk condition, vaccination status, interval from illness onset to enrollment, general health status, self or household exposure to smoke, and number of children ages <12 years in the household. The Wilcoxon–Mann–Whitney test was used to assess differences with respect to the distribution of the current health assessment. A P value of <.05 is statistically significant.

b Data were missing for 10 enrollees.

c Defined as a body mass index of ≥40, calculated as the weight in kilograms divided by the height in meters squared. Data were missing for 312 enrollees.

d Vaccination status (≥14 days prior to illness onset) was determined by a combination of EIR and plausible off-site self-report or report by the parent or guardian. Persons aged ≥50 years with unknown vaccine type were assumed to have received inactivated vaccine (Figure 1).

e Vaccination status (≥14 days prior to illness onset) determined by EIR.

f Data were missing for 4 enrollees.

g Data were missing for 3 enrollees.

h Possible values range from 1 (the worst) to 100 (the best). Data were missing for 6 enrollees.

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