Table 3 Open in new tab Multivariate Cox...

	Death (n = 41 873)	Amputation (n = 41 860)	MI (n = 41 860)	Ischaemic stroke (n = 41 873)
RF 1–3	1		1		1		1
RF 4	2.04 (1.91–2.18)	<0.001	3.11 (2.76–3.49)	<0.001	1.32 (1.15–1.51)	<0.001	1.43 (1.23–1.65)	<0.001
RF 5	2.53 (2.39–2.68)	<0.001	9.28 (8.47–10.17)	<0.001	1.29 (1.14–1.47)	<0.001	1.32 (1.15–1.51)	<0.001
RF 6	3.75 (3.56–3.96)	<0.001	29.00 (26.67–31.55)	<0.001	1.29 (1.14–1.46)	<0.001	1.50 (1.32–1.72)	<0.001
Age	1.06 (1.06–1.06)	<0.001	1.00 (1.00–1.00)	0.157	1.02 (1.02–1.03)	<0.001	1.03 (1.03–1.04)	<0.001
Male	1.21 (1.16–1.25)	<0.001	1.33 (1.27–1.39)	<0.001	1.27 (1.16–1.40)	<0.001	1.07 (0.96–1.18)	0.226
Hypertension	0.83 (0.79–0.86)	<0.001	0.93 (0.89–0.98)	0.003	0.91 (0.82–1.00)	0.059	1.07 (0.96–1.20)	0.229
Obesity	0.88 (0.81–0.95)	0.002	0.93 (0.86–1.01)	0.104	1.03 (0.88–1.21)	0.729	0.98 (0.81–1.18)	0.825
Dyslipidaemia	0.74 (0.70–0.77)	<0.001	0.84 (0.80–0.89)	<0.001	0.92 (0.83–1.01)	0.091	0.91 (0.81–1.01)	0.083
Smoking	1.05 (0.97–1.14)	0.265	0.835 (0.76–0.92)	<0.001	0.99 (0.85–1.18)	0.989	1.07 (0.90–1.28)	0.446
Diabetes	1.05 (1.00–1.09)	0.033	1.473 (1.41–1.54)	<0.001	1.28 (1.17–1.41)	<0.001	1.30 (1.17–1.44)	<0.001
CAD	1.24 (1.19–1.30)	<0.001	1.00 (0.95–1.05)	0.976	2.02 (1.84–2.22)	<0.001	0.97 (0.86–1.09)	0.554
CHF	1.62 (1.54–1.70)	<0.001	1.10 (1.03–1.17)	0.003	1.64 (1.44–1.85)	<0.001	1.27 (1.09–1.49)	0.002
CKD	1.47 (1.41–1.53)	<0.001	1.12 (1.07–1.18)	<0.001	1.30 (1.17–1.44)	<0.001	1.05 (0.93–1.18)	0.439
Malignancies	2.16 (1.96–2.38)	<0.001	0.91 (0.78–1.05)	0.203	1.14 (0.82–1.58)	0.428	0.97 (0.65–1.44)	0.874
Harrell's C^a	0.78		0.85		0.68		0.64

Death (n = 41 873)

Amputation (n = 41 860)

MI (n = 41 860)

Ischaemic stroke (n = 41 873)

HR (95% CI)

RF 1–3

RF 4

2.04 (1.91–2.18)

<0.001

3.11 (2.76–3.49)

<0.001

1.32 (1.15–1.51)

<0.001

1.43 (1.23–1.65)

<0.001

RF 5

2.53 (2.39–2.68)

<0.001

9.28 (8.47–10.17)

<0.001

1.29 (1.14–1.47)

<0.001

1.32 (1.15–1.51)

<0.001

RF 6

3.75 (3.56–3.96)

<0.001

29.00 (26.67–31.55)

<0.001

1.29 (1.14–1.46)

<0.001

1.50 (1.32–1.72)

<0.001

Age

1.06 (1.06–1.06)

<0.001

1.00 (1.00–1.00)

0.157

1.02 (1.02–1.03)

<0.001

1.03 (1.03–1.04)

<0.001

Male

1.21 (1.16–1.25)

<0.001

1.33 (1.27–1.39)

<0.001

1.27 (1.16–1.40)

<0.001

1.07 (0.96–1.18)

0.226

Hypertension

0.83 (0.79–0.86)

<0.001

0.93 (0.89–0.98)

0.003

0.91 (0.82–1.00)

0.059

1.07 (0.96–1.20)

0.229

Obesity

0.88 (0.81–0.95)

0.002

0.93 (0.86–1.01)

0.104

1.03 (0.88–1.21)

0.729

0.98 (0.81–1.18)

0.825

Dyslipidaemia

0.74 (0.70–0.77)

<0.001

0.84 (0.80–0.89)

<0.001

0.92 (0.83–1.01)

0.091

0.91 (0.81–1.01)

0.083

Smoking

1.05 (0.97–1.14)

0.265

0.835 (0.76–0.92)

<0.001

0.99 (0.85–1.18)

0.989

1.07 (0.90–1.28)

0.446

Diabetes

1.05 (1.00–1.09)

0.033

1.473 (1.41–1.54)

<0.001

1.28 (1.17–1.41)

<0.001

1.30 (1.17–1.44)

<0.001

CAD

1.24 (1.19–1.30)

<0.001

1.00 (0.95–1.05)

0.976

2.02 (1.84–2.22)

<0.001

0.97 (0.86–1.09)

0.554

CHF

1.62 (1.54–1.70)

<0.001

1.10 (1.03–1.17)

0.003

1.64 (1.44–1.85)

<0.001

1.27 (1.09–1.49)

0.002

CKD

1.47 (1.41–1.53)

<0.001

1.12 (1.07–1.18)

<0.001

1.30 (1.17–1.44)

<0.001

1.05 (0.93–1.18)

0.439

Malignancies

2.16 (1.96–2.38)

<0.001

0.91 (0.78–1.05)

0.203

1.14 (0.82–1.58)

0.428

0.97 (0.65–1.44)

0.874

Harrell's C^a

0.78

0.85

0.68

0.64

	Death (n = 41 873)	Amputation (n = 41 860)	MI (n = 41 860)	Ischaemic stroke (n = 41 873)
RF 1–3	1		1		1		1
RF 4	2.04 (1.91–2.18)	<0.001	3.11 (2.76–3.49)	<0.001	1.32 (1.15–1.51)	<0.001	1.43 (1.23–1.65)	<0.001
RF 5	2.53 (2.39–2.68)	<0.001	9.28 (8.47–10.17)	<0.001	1.29 (1.14–1.47)	<0.001	1.32 (1.15–1.51)	<0.001
RF 6	3.75 (3.56–3.96)	<0.001	29.00 (26.67–31.55)	<0.001	1.29 (1.14–1.46)	<0.001	1.50 (1.32–1.72)	<0.001
Age	1.06 (1.06–1.06)	<0.001	1.00 (1.00–1.00)	0.157	1.02 (1.02–1.03)	<0.001	1.03 (1.03–1.04)	<0.001
Male	1.21 (1.16–1.25)	<0.001	1.33 (1.27–1.39)	<0.001	1.27 (1.16–1.40)	<0.001	1.07 (0.96–1.18)	0.226
Hypertension	0.83 (0.79–0.86)	<0.001	0.93 (0.89–0.98)	0.003	0.91 (0.82–1.00)	0.059	1.07 (0.96–1.20)	0.229
Obesity	0.88 (0.81–0.95)	0.002	0.93 (0.86–1.01)	0.104	1.03 (0.88–1.21)	0.729	0.98 (0.81–1.18)	0.825
Dyslipidaemia	0.74 (0.70–0.77)	<0.001	0.84 (0.80–0.89)	<0.001	0.92 (0.83–1.01)	0.091	0.91 (0.81–1.01)	0.083
Smoking	1.05 (0.97–1.14)	0.265	0.835 (0.76–0.92)	<0.001	0.99 (0.85–1.18)	0.989	1.07 (0.90–1.28)	0.446
Diabetes	1.05 (1.00–1.09)	0.033	1.473 (1.41–1.54)	<0.001	1.28 (1.17–1.41)	<0.001	1.30 (1.17–1.44)	<0.001
CAD	1.24 (1.19–1.30)	<0.001	1.00 (0.95–1.05)	0.976	2.02 (1.84–2.22)	<0.001	0.97 (0.86–1.09)	0.554
CHF	1.62 (1.54–1.70)	<0.001	1.10 (1.03–1.17)	0.003	1.64 (1.44–1.85)	<0.001	1.27 (1.09–1.49)	0.002
CKD	1.47 (1.41–1.53)	<0.001	1.12 (1.07–1.18)	<0.001	1.30 (1.17–1.44)	<0.001	1.05 (0.93–1.18)	0.439
Malignancies	2.16 (1.96–2.38)	<0.001	0.91 (0.78–1.05)	0.203	1.14 (0.82–1.58)	0.428	0.97 (0.65–1.44)	0.874
Harrell's C^a	0.78		0.85		0.68		0.64

Table 3

Open in new tab

Multivariate Cox regression analyses of predictors for long-term outcomes

	Death (n = 41 873)		Amputation (n = 41 860)		MI (n = 41 860)		Ischaemic stroke (n = 41 873)
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
RF 1–3	1		1		1		1
RF 4	2.04 (1.91–2.18)	<0.001	3.11 (2.76–3.49)	<0.001	1.32 (1.15–1.51)	<0.001	1.43 (1.23–1.65)	<0.001
RF 5	2.53 (2.39–2.68)	<0.001	9.28 (8.47–10.17)	<0.001	1.29 (1.14–1.47)	<0.001	1.32 (1.15–1.51)	<0.001
RF 6	3.75 (3.56–3.96)	<0.001	29.00 (26.67–31.55)	<0.001	1.29 (1.14–1.46)	<0.001	1.50 (1.32–1.72)	<0.001
Age	1.06 (1.06–1.06)	<0.001	1.00 (1.00–1.00)	0.157	1.02 (1.02–1.03)	<0.001	1.03 (1.03–1.04)	<0.001
Male	1.21 (1.16–1.25)	<0.001	1.33 (1.27–1.39)	<0.001	1.27 (1.16–1.40)	<0.001	1.07 (0.96–1.18)	0.226
Hypertension	0.83 (0.79–0.86)	<0.001	0.93 (0.89–0.98)	0.003	0.91 (0.82–1.00)	0.059	1.07 (0.96–1.20)	0.229
Obesity	0.88 (0.81–0.95)	0.002	0.93 (0.86–1.01)	0.104	1.03 (0.88–1.21)	0.729	0.98 (0.81–1.18)	0.825
Dyslipidaemia	0.74 (0.70–0.77)	<0.001	0.84 (0.80–0.89)	<0.001	0.92 (0.83–1.01)	0.091	0.91 (0.81–1.01)	0.083
Smoking	1.05 (0.97–1.14)	0.265	0.835 (0.76–0.92)	<0.001	0.99 (0.85–1.18)	0.989	1.07 (0.90–1.28)	0.446
Diabetes	1.05 (1.00–1.09)	0.033	1.473 (1.41–1.54)	<0.001	1.28 (1.17–1.41)	<0.001	1.30 (1.17–1.44)	<0.001
CAD	1.24 (1.19–1.30)	<0.001	1.00 (0.95–1.05)	0.976	2.02 (1.84–2.22)	<0.001	0.97 (0.86–1.09)	0.554
CHF	1.62 (1.54–1.70)	<0.001	1.10 (1.03–1.17)	0.003	1.64 (1.44–1.85)	<0.001	1.27 (1.09–1.49)	0.002
CKD	1.47 (1.41–1.53)	<0.001	1.12 (1.07–1.18)	<0.001	1.30 (1.17–1.44)	<0.001	1.05 (0.93–1.18)	0.439
Malignancies	2.16 (1.96–2.38)	<0.001	0.91 (0.78–1.05)	0.203	1.14 (0.82–1.58)	0.428	0.97 (0.65–1.44)	0.874
Harrell's C^a	0.78		0.85		0.68		0.64

	Death (n = 41 873)		Amputation (n = 41 860)		MI (n = 41 860)		Ischaemic stroke (n = 41 873)
	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
RF 1–3	1		1		1		1
RF 4	2.04 (1.91–2.18)	<0.001	3.11 (2.76–3.49)	<0.001	1.32 (1.15–1.51)	<0.001	1.43 (1.23–1.65)	<0.001
RF 5	2.53 (2.39–2.68)	<0.001	9.28 (8.47–10.17)	<0.001	1.29 (1.14–1.47)	<0.001	1.32 (1.15–1.51)	<0.001
RF 6	3.75 (3.56–3.96)	<0.001	29.00 (26.67–31.55)	<0.001	1.29 (1.14–1.46)	<0.001	1.50 (1.32–1.72)	<0.001
Age	1.06 (1.06–1.06)	<0.001	1.00 (1.00–1.00)	0.157	1.02 (1.02–1.03)	<0.001	1.03 (1.03–1.04)	<0.001
Male	1.21 (1.16–1.25)	<0.001	1.33 (1.27–1.39)	<0.001	1.27 (1.16–1.40)	<0.001	1.07 (0.96–1.18)	0.226
Hypertension	0.83 (0.79–0.86)	<0.001	0.93 (0.89–0.98)	0.003	0.91 (0.82–1.00)	0.059	1.07 (0.96–1.20)	0.229
Obesity	0.88 (0.81–0.95)	0.002	0.93 (0.86–1.01)	0.104	1.03 (0.88–1.21)	0.729	0.98 (0.81–1.18)	0.825
Dyslipidaemia	0.74 (0.70–0.77)	<0.001	0.84 (0.80–0.89)	<0.001	0.92 (0.83–1.01)	0.091	0.91 (0.81–1.01)	0.083
Smoking	1.05 (0.97–1.14)	0.265	0.835 (0.76–0.92)	<0.001	0.99 (0.85–1.18)	0.989	1.07 (0.90–1.28)	0.446
Diabetes	1.05 (1.00–1.09)	0.033	1.473 (1.41–1.54)	<0.001	1.28 (1.17–1.41)	<0.001	1.30 (1.17–1.44)	<0.001
CAD	1.24 (1.19–1.30)	<0.001	1.00 (0.95–1.05)	0.976	2.02 (1.84–2.22)	<0.001	0.97 (0.86–1.09)	0.554
CHF	1.62 (1.54–1.70)	<0.001	1.10 (1.03–1.17)	0.003	1.64 (1.44–1.85)	<0.001	1.27 (1.09–1.49)	0.002
CKD	1.47 (1.41–1.53)	<0.001	1.12 (1.07–1.18)	<0.001	1.30 (1.17–1.44)	<0.001	1.05 (0.93–1.18)	0.439
Malignancies	2.16 (1.96–2.38)	<0.001	0.91 (0.78–1.05)	0.203	1.14 (0.82–1.58)	0.428	0.97 (0.65–1.44)	0.874
Harrell's C^a	0.78		0.85		0.68		0.64

CAD, coronary artery disease; CHF, chronic heart failure, CKD, chronic kidney disease; CI, confidence interval; HR, hazard ratio; MI, myocardial infarction; RF, Rutherford category.

Comorbidities were defined on the basis of given ICD-10 codes, and are presented in detail in Supplementary material online, Table S1.

Significant P-values were presented in bold.

^aA value for Harrell's C = 0.5 suggests no discrimination; 0.7 ≤ C < 0.8 is considered acceptable discrimination; 0.8 ≤ C < 0.9 is considered as excellent discrimination; C ≥ 0.9 is considered as outstanding discrimination.

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