Table 2. Open in new tab Standardized 5-...

Treatment Plan	5-year	10-year
No intervention	5.45					12.60
All ages
500 cells/mm³	4.63	1		0		10.80	1		0
350 cells/mm³	5.30	1.15	1.05, 1.26	0.67	.23, 1.11	11.66	1.08	1.00, 1.16	0.87	.07, 1.67
200 cells/mm³	6.17	1.33	1.15, 1.54	1.54	.72, 2.36	13.51	1.25	1.08, 1.44	2.71	.92, 4.50
18 to 34 years of age
500 cells/mm³	2.11	1		0		6.11	1		0
350 cells/mm³	2.22	1.05	.87, 1.27	0.11	−.33, .55	6.08	1.00	.87, 1.15	−0.03	−.83, .77
200 cells/mm³	2.45	1.16	.84, 1.60	0.34	−.40, 1.08	6.25	1.02	.78, 1.33	0.14	−1.48, 1.76
35 to 44 years of age
500 cells/mm³	5.09	1		0		11.43	1		0
350 cells/mm³	5.51	1.08	.95, 1.22	0.42	−.23, 1.07	12.42	1.09	.99, 1.20	0.99	−.13, 2.11
200 cells/mm³	5.76	1.13	.91, 1.41	0.67	−.59, 1.93	13.59	1.19	1.98, 1.45	2.15	−.39, 4.69
45 to 65 years of age
500 cells/mm³	9.17	1		0		19.29	1		0
350 cells/mm³	11.28	1.23	1.08, 1.40	2.11	.80, 3.42	21.60	1.12	1.01, 1.25	2.30	.23, 4.37
200 cells/mm³	14.50	1.58	1.31, 1.90	5.33	3.15, 7.51	28.07	1.45	1.21,1.71	8.78	5.89, 13.90

Treatment Plan

5-year

10-year

Mortality

95% CI

Mortality

95% CI

No intervention

5.45

12.60

All ages

500 cells/mm³

4.63

10.80

350 cells/mm³

5.30

1.15

1.05, 1.26

0.67

.23, 1.11

11.66

1.08

1.00, 1.16

0.87

.07, 1.67

200 cells/mm³

6.17

1.33

1.15, 1.54

1.54

.72, 2.36

13.51

1.25

1.08, 1.44

2.71

.92, 4.50

18 to 34 years of age

500 cells/mm³

2.11

6.11

350 cells/mm³

2.22

1.05

.87, 1.27

0.11

−.33, .55

6.08

1.00

.87, 1.15

−0.03

−.83, .77

200 cells/mm³

2.45

1.16

.84, 1.60

0.34

−.40, 1.08

6.25

1.02

.78, 1.33

0.14

−1.48, 1.76

35 to 44 years of age

500 cells/mm³

5.09

11.43

350 cells/mm³

5.51

1.08

.95, 1.22

0.42

−.23, 1.07

12.42

1.09

.99, 1.20

0.99

−.13, 2.11

200 cells/mm³

5.76

1.13

.91, 1.41

0.67

−.59, 1.93

13.59

1.19

1.98, 1.45

2.15

−.39, 4.69

45 to 65 years of age

500 cells/mm³

9.17

19.29

350 cells/mm³

11.28

1.23

1.08, 1.40

2.11

.80, 3.42

21.60

1.12

1.01, 1.25

2.30

.23, 4.37

200 cells/mm³

14.50

1.58

1.31, 1.90

5.33

3.15, 7.51

28.07

1.45

1.21,1.71

8.78

5.89, 13.90

Treatment Plan	5-year	10-year
No intervention	5.45					12.60
All ages
500 cells/mm³	4.63	1		0		10.80	1		0
350 cells/mm³	5.30	1.15	1.05, 1.26	0.67	.23, 1.11	11.66	1.08	1.00, 1.16	0.87	.07, 1.67
200 cells/mm³	6.17	1.33	1.15, 1.54	1.54	.72, 2.36	13.51	1.25	1.08, 1.44	2.71	.92, 4.50
18 to 34 years of age
500 cells/mm³	2.11	1		0		6.11	1		0
350 cells/mm³	2.22	1.05	.87, 1.27	0.11	−.33, .55	6.08	1.00	.87, 1.15	−0.03	−.83, .77
200 cells/mm³	2.45	1.16	.84, 1.60	0.34	−.40, 1.08	6.25	1.02	.78, 1.33	0.14	−1.48, 1.76
35 to 44 years of age
500 cells/mm³	5.09	1		0		11.43	1		0
350 cells/mm³	5.51	1.08	.95, 1.22	0.42	−.23, 1.07	12.42	1.09	.99, 1.20	0.99	−.13, 2.11
200 cells/mm³	5.76	1.13	.91, 1.41	0.67	−.59, 1.93	13.59	1.19	1.98, 1.45	2.15	−.39, 4.69
45 to 65 years of age
500 cells/mm³	9.17	1		0		19.29	1		0
350 cells/mm³	11.28	1.23	1.08, 1.40	2.11	.80, 3.42	21.60	1.12	1.01, 1.25	2.30	.23, 4.37
200 cells/mm³	14.50	1.58	1.31, 1.90	5.33	3.15, 7.51	28.07	1.45	1.21,1.71	8.78	5.89, 13.90

Table 2.

Open in new tab

Standardized 5- and 10-Year Cumulative Incidence of Mortality Under no Intervention and 3 Dynamic Treatment Plans With a 6-Month Grace Period Among 3532 Patients Who Entered Care Between 1 January 1998 and 31 December 2013 at 8 US Clinical Sites, Followed for Death for Up to 10 Years

Treatment Plan	5-year					10-year
Treatment Plan	Mortality	RR	95% CI	RD	95% CI	Mortality	RR	95% CI	RD	95% CI
No intervention	5.45					12.60
All ages
500 cells/mm³	4.63	1		0		10.80	1		0
350 cells/mm³	5.30	1.15	1.05, 1.26	0.67	.23, 1.11	11.66	1.08	1.00, 1.16	0.87	.07, 1.67
200 cells/mm³	6.17	1.33	1.15, 1.54	1.54	.72, 2.36	13.51	1.25	1.08, 1.44	2.71	.92, 4.50
18 to 34 years of age
500 cells/mm³	2.11	1		0		6.11	1		0
350 cells/mm³	2.22	1.05	.87, 1.27	0.11	−.33, .55	6.08	1.00	.87, 1.15	−0.03	−.83, .77
200 cells/mm³	2.45	1.16	.84, 1.60	0.34	−.40, 1.08	6.25	1.02	.78, 1.33	0.14	−1.48, 1.76
35 to 44 years of age
500 cells/mm³	5.09	1		0		11.43	1		0
350 cells/mm³	5.51	1.08	.95, 1.22	0.42	−.23, 1.07	12.42	1.09	.99, 1.20	0.99	−.13, 2.11
200 cells/mm³	5.76	1.13	.91, 1.41	0.67	−.59, 1.93	13.59	1.19	1.98, 1.45	2.15	−.39, 4.69
45 to 65 years of age
500 cells/mm³	9.17	1		0		19.29	1		0
350 cells/mm³	11.28	1.23	1.08, 1.40	2.11	.80, 3.42	21.60	1.12	1.01, 1.25	2.30	.23, 4.37
200 cells/mm³	14.50	1.58	1.31, 1.90	5.33	3.15, 7.51	28.07	1.45	1.21,1.71	8.78	5.89, 13.90

Treatment Plan	5-year					10-year
Treatment Plan	Mortality	RR	95% CI	RD	95% CI	Mortality	RR	95% CI	RD	95% CI
No intervention	5.45					12.60
All ages
500 cells/mm³	4.63	1		0		10.80	1		0
350 cells/mm³	5.30	1.15	1.05, 1.26	0.67	.23, 1.11	11.66	1.08	1.00, 1.16	0.87	.07, 1.67
200 cells/mm³	6.17	1.33	1.15, 1.54	1.54	.72, 2.36	13.51	1.25	1.08, 1.44	2.71	.92, 4.50
18 to 34 years of age
500 cells/mm³	2.11	1		0		6.11	1		0
350 cells/mm³	2.22	1.05	.87, 1.27	0.11	−.33, .55	6.08	1.00	.87, 1.15	−0.03	−.83, .77
200 cells/mm³	2.45	1.16	.84, 1.60	0.34	−.40, 1.08	6.25	1.02	.78, 1.33	0.14	−1.48, 1.76
35 to 44 years of age
500 cells/mm³	5.09	1		0		11.43	1		0
350 cells/mm³	5.51	1.08	.95, 1.22	0.42	−.23, 1.07	12.42	1.09	.99, 1.20	0.99	−.13, 2.11
200 cells/mm³	5.76	1.13	.91, 1.41	0.67	−.59, 1.93	13.59	1.19	1.98, 1.45	2.15	−.39, 4.69
45 to 65 years of age
500 cells/mm³	9.17	1		0		19.29	1		0
350 cells/mm³	11.28	1.23	1.08, 1.40	2.11	.80, 3.42	21.60	1.12	1.01, 1.25	2.30	.23, 4.37
200 cells/mm³	14.50	1.58	1.31, 1.90	5.33	3.15, 7.51	28.07	1.45	1.21,1.71	8.78	5.89, 13.90

Abbreviations: CI, confidence interval; RD, risk difference; RR, risk ratio.

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