Meta-analysis of CARe and additional African-origin cohorts, as well as the P-values in ICBP
| SNP ID . | Chr . | Position . | Type . | Nearest gene . | SBP . | DBP . | ||
|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Meta P . | ICBP P . | Meta P . | ICBP P . |
| rs10474346 | 5 | 90 599 895 | Affy6 Imputed | GPR98/ARRDC3 | 9.96 × 10−3 | 5.19 × 10−1 | 1.02 × 10−3 | 5.65 × 10−1 |
| rs13413144 | 2 | 153 183 499 | Affy6 Imputed | FMNL2 | 9.28 × 10−4 | 4.22 × 10−1 | 1.06 × 10−1 | 8.00 × 10−1 |
| rs17610514a | 11 | 55 652 374 | CARDIA | Olfactory | 8.50 × 10−5 | 2.59 × 10−1 | 3.90 × 10−5 | 2.20 × 10−1 |
| rs1990151 | 1 | 44 186 879 | Affy6 Genotyped | IPO13 | 1.14 × 10−3 | 8.20 × 10−1 | 8.63 × 10−3 | 8.14 × 10−1 |
| rs2012318 | 19 | 19 069 240 | IBC Genotyped | SLC25A42 | 5.68 × 10−6 | 5.92 × 10−1 | 6.21 × 10−3 | 6.04 × 10−1 |
| rs214070b | 11 | 17 261 893 | IBC Genotyped | NUCB2 | NA | 3.23 × 10−2 | NA | 1.67 × 10−2 |
| rs2258119 | 21 | 18 089 350 | Affy6 Genotyped | C21orf91 | 5.00 × 10−4 | 5.28 × 10−1 | 1.41 × 10−2 | 6.54 × 10−1 |
| rs592582 | 2 | 157 481 632 | Affy6 Imputed | GPD2 | 9.15 × 10−3 | 9.16 × 10−1 | 1.22 × 10−1 | 6.59 × 10−1 |
| rs7709572 | 5 | 90 592 789 | Affy6 Genotyped | GPR98 | 1.38 × 10−2 | 4.56 × 10−1 | 6.49 × 10−4 | 5.68 × 10−1 |
| SNP ID . | Chr . | Position . | Type . | Nearest gene . | SBP . | DBP . | ||
|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Meta P . | ICBP P . | Meta P . | ICBP P . |
| rs10474346 | 5 | 90 599 895 | Affy6 Imputed | GPR98/ARRDC3 | 9.96 × 10−3 | 5.19 × 10−1 | 1.02 × 10−3 | 5.65 × 10−1 |
| rs13413144 | 2 | 153 183 499 | Affy6 Imputed | FMNL2 | 9.28 × 10−4 | 4.22 × 10−1 | 1.06 × 10−1 | 8.00 × 10−1 |
| rs17610514a | 11 | 55 652 374 | CARDIA | Olfactory | 8.50 × 10−5 | 2.59 × 10−1 | 3.90 × 10−5 | 2.20 × 10−1 |
| rs1990151 | 1 | 44 186 879 | Affy6 Genotyped | IPO13 | 1.14 × 10−3 | 8.20 × 10−1 | 8.63 × 10−3 | 8.14 × 10−1 |
| rs2012318 | 19 | 19 069 240 | IBC Genotyped | SLC25A42 | 5.68 × 10−6 | 5.92 × 10−1 | 6.21 × 10−3 | 6.04 × 10−1 |
| rs214070b | 11 | 17 261 893 | IBC Genotyped | NUCB2 | NA | 3.23 × 10−2 | NA | 1.67 × 10−2 |
| rs2258119 | 21 | 18 089 350 | Affy6 Genotyped | C21orf91 | 5.00 × 10−4 | 5.28 × 10−1 | 1.41 × 10−2 | 6.54 × 10−1 |
| rs592582 | 2 | 157 481 632 | Affy6 Imputed | GPD2 | 9.15 × 10−3 | 9.16 × 10−1 | 1.22 × 10−1 | 6.59 × 10−1 |
| rs7709572 | 5 | 90 592 789 | Affy6 Genotyped | GPR98 | 1.38 × 10−2 | 4.56 × 10−1 | 6.49 × 10−4 | 5.68 × 10−1 |
Meta P, P-value by combining all cohorts of African ancestry;
ICBP P, one-sided P-value in ICBP data. For SNPs genotyped in Affy6, P-value < 5 × 10−8 is considered as statistically significant. For SNPs genotyped in IBC chip, P-value <2 × 10−6 is considered as statistically significant.
aSNP rs17610514, failed WHI QC due to low concordance rate among duplicates (<98%) and/or low call rate (<95%) and thus was not included in the meta-analysis.
bSNP rs214070 was not genotyped in the cohorts of African ancestry except CARe.
Meta-analysis of CARe and additional African-origin cohorts, as well as the P-values in ICBP
| SNP ID . | Chr . | Position . | Type . | Nearest gene . | SBP . | DBP . | ||
|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Meta P . | ICBP P . | Meta P . | ICBP P . |
| rs10474346 | 5 | 90 599 895 | Affy6 Imputed | GPR98/ARRDC3 | 9.96 × 10−3 | 5.19 × 10−1 | 1.02 × 10−3 | 5.65 × 10−1 |
| rs13413144 | 2 | 153 183 499 | Affy6 Imputed | FMNL2 | 9.28 × 10−4 | 4.22 × 10−1 | 1.06 × 10−1 | 8.00 × 10−1 |
| rs17610514a | 11 | 55 652 374 | CARDIA | Olfactory | 8.50 × 10−5 | 2.59 × 10−1 | 3.90 × 10−5 | 2.20 × 10−1 |
| rs1990151 | 1 | 44 186 879 | Affy6 Genotyped | IPO13 | 1.14 × 10−3 | 8.20 × 10−1 | 8.63 × 10−3 | 8.14 × 10−1 |
| rs2012318 | 19 | 19 069 240 | IBC Genotyped | SLC25A42 | 5.68 × 10−6 | 5.92 × 10−1 | 6.21 × 10−3 | 6.04 × 10−1 |
| rs214070b | 11 | 17 261 893 | IBC Genotyped | NUCB2 | NA | 3.23 × 10−2 | NA | 1.67 × 10−2 |
| rs2258119 | 21 | 18 089 350 | Affy6 Genotyped | C21orf91 | 5.00 × 10−4 | 5.28 × 10−1 | 1.41 × 10−2 | 6.54 × 10−1 |
| rs592582 | 2 | 157 481 632 | Affy6 Imputed | GPD2 | 9.15 × 10−3 | 9.16 × 10−1 | 1.22 × 10−1 | 6.59 × 10−1 |
| rs7709572 | 5 | 90 592 789 | Affy6 Genotyped | GPR98 | 1.38 × 10−2 | 4.56 × 10−1 | 6.49 × 10−4 | 5.68 × 10−1 |
| SNP ID . | Chr . | Position . | Type . | Nearest gene . | SBP . | DBP . | ||
|---|---|---|---|---|---|---|---|---|
| . | . | . | . | . | Meta P . | ICBP P . | Meta P . | ICBP P . |
| rs10474346 | 5 | 90 599 895 | Affy6 Imputed | GPR98/ARRDC3 | 9.96 × 10−3 | 5.19 × 10−1 | 1.02 × 10−3 | 5.65 × 10−1 |
| rs13413144 | 2 | 153 183 499 | Affy6 Imputed | FMNL2 | 9.28 × 10−4 | 4.22 × 10−1 | 1.06 × 10−1 | 8.00 × 10−1 |
| rs17610514a | 11 | 55 652 374 | CARDIA | Olfactory | 8.50 × 10−5 | 2.59 × 10−1 | 3.90 × 10−5 | 2.20 × 10−1 |
| rs1990151 | 1 | 44 186 879 | Affy6 Genotyped | IPO13 | 1.14 × 10−3 | 8.20 × 10−1 | 8.63 × 10−3 | 8.14 × 10−1 |
| rs2012318 | 19 | 19 069 240 | IBC Genotyped | SLC25A42 | 5.68 × 10−6 | 5.92 × 10−1 | 6.21 × 10−3 | 6.04 × 10−1 |
| rs214070b | 11 | 17 261 893 | IBC Genotyped | NUCB2 | NA | 3.23 × 10−2 | NA | 1.67 × 10−2 |
| rs2258119 | 21 | 18 089 350 | Affy6 Genotyped | C21orf91 | 5.00 × 10−4 | 5.28 × 10−1 | 1.41 × 10−2 | 6.54 × 10−1 |
| rs592582 | 2 | 157 481 632 | Affy6 Imputed | GPD2 | 9.15 × 10−3 | 9.16 × 10−1 | 1.22 × 10−1 | 6.59 × 10−1 |
| rs7709572 | 5 | 90 592 789 | Affy6 Genotyped | GPR98 | 1.38 × 10−2 | 4.56 × 10−1 | 6.49 × 10−4 | 5.68 × 10−1 |
Meta P, P-value by combining all cohorts of African ancestry;
ICBP P, one-sided P-value in ICBP data. For SNPs genotyped in Affy6, P-value < 5 × 10−8 is considered as statistically significant. For SNPs genotyped in IBC chip, P-value <2 × 10−6 is considered as statistically significant.
aSNP rs17610514, failed WHI QC due to low concordance rate among duplicates (<98%) and/or low call rate (<95%) and thus was not included in the meta-analysis.
bSNP rs214070 was not genotyped in the cohorts of African ancestry except CARe.
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